Dietary restriction
Dietary restriction (DR) slows the rate of actuarial aging of rats and mice and in addition retards and/or delays many phenotypic characteristics of aging such as the age-associated deterioration of physiological systems and the occurrence and progression of age-associated disease. These antiaging a...
Gespeichert in:
| Veröffentlicht in: | Experimental gerontology 1995-05, Vol.30 (3), p.291-298 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 298 |
|---|---|
| container_issue | 3 |
| container_start_page | 291 |
| container_title | Experimental gerontology |
| container_volume | 30 |
| creator | Masoro, Edward J. |
| description | Dietary restriction (DR) slows the rate of actuarial aging of rats and mice and in addition retards and/or delays many phenotypic characteristics of aging such as the age-associated deterioration of physiological systems and the occurrence and progression of age-associated disease. These antiaging actions result from a reduction of energy intake by the animal but are not due to a decrease in metabolic rate per unit of lean body mass. However, there is evidence that altered characteristics of fuel use (but not the intensity of fuel use) may underlie the antiaging action of DR. There is also evidence that DR has a general protective action in regard to damage caused by acute stressors; possibly a similar protective action in regard to damage caused by prolonged, low intensity aging processes plays a major role in the antiaging action of DR. |
| doi_str_mv | 10.1016/0531-5565(94)00028-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77570646</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0531556594000282</els_id><sourcerecordid>77570646</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-5a786e67d26c9636ddf1d4f78ddec751b618efb3e28fe9ae0c0010bf533bf6243</originalsourceid><addsrcrecordid>eNp9UEtLAzEQDqLUWj15VfAkelidJJvHXgSpTyh40XPYTSYQ2XZrshX892bt0qOngZnvMd9HyBmFGwpU3oLgtBBCiquqvAYApgu2R6ZUK15ITcU-me4gh-Qopc8MkozTCZmoYQl6Sk4fAvZ1_LmImPoYbB-61TE58HWb8GScM_Lx9Pg-fykWb8-v8_tFYblQfSFqpSVK5Zi0leTSOU9d6ZV2Dq0StJFUo284Mu2xqhEsAIXGC84bL1nJZ-Ryq7uO3dcm-5tlSBbbtl5ht0lGKaFAljIDyy3Qxi6liN6sY1jmrw0FM3RhhqBmyGSq0vx1YVimnY_6m2aJbkcaw-f73faOOeR3wGiSDbiy6EJE2xvXhf8NfgG9K2wV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77570646</pqid></control><display><type>article</type><title>Dietary restriction</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Masoro, Edward J.</creator><creatorcontrib>Masoro, Edward J.</creatorcontrib><description>Dietary restriction (DR) slows the rate of actuarial aging of rats and mice and in addition retards and/or delays many phenotypic characteristics of aging such as the age-associated deterioration of physiological systems and the occurrence and progression of age-associated disease. These antiaging actions result from a reduction of energy intake by the animal but are not due to a decrease in metabolic rate per unit of lean body mass. However, there is evidence that altered characteristics of fuel use (but not the intensity of fuel use) may underlie the antiaging action of DR. There is also evidence that DR has a general protective action in regard to damage caused by acute stressors; possibly a similar protective action in regard to damage caused by prolonged, low intensity aging processes plays a major role in the antiaging action of DR.</description><identifier>ISSN: 0531-5565</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/0531-5565(94)00028-2</identifier><identifier>PMID: 7556508</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aging - physiology ; Animals ; biological age ; Blood Glucose - metabolism ; carbohydrate metabolism ; Circadian Rhythm - physiology ; Corticosterone - blood ; Diet ; dietary restriction ; Endocrine Glands - physiology ; Energy Intake ; glucocorticoids ; glycemia ; Gompertz analysis ; heat shock proteins ; insulinemia ; Male ; metabolic rate ; Mice ; Models, Biological ; Nervous System Physiological Phenomena ; Phenotype ; Rats ; Rats, Inbred F344</subject><ispartof>Experimental gerontology, 1995-05, Vol.30 (3), p.291-298</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-5a786e67d26c9636ddf1d4f78ddec751b618efb3e28fe9ae0c0010bf533bf6243</citedby><cites>FETCH-LOGICAL-c357t-5a786e67d26c9636ddf1d4f78ddec751b618efb3e28fe9ae0c0010bf533bf6243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0531556594000282$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7556508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masoro, Edward J.</creatorcontrib><title>Dietary restriction</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>Dietary restriction (DR) slows the rate of actuarial aging of rats and mice and in addition retards and/or delays many phenotypic characteristics of aging such as the age-associated deterioration of physiological systems and the occurrence and progression of age-associated disease. These antiaging actions result from a reduction of energy intake by the animal but are not due to a decrease in metabolic rate per unit of lean body mass. However, there is evidence that altered characteristics of fuel use (but not the intensity of fuel use) may underlie the antiaging action of DR. There is also evidence that DR has a general protective action in regard to damage caused by acute stressors; possibly a similar protective action in regard to damage caused by prolonged, low intensity aging processes plays a major role in the antiaging action of DR.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>biological age</subject><subject>Blood Glucose - metabolism</subject><subject>carbohydrate metabolism</subject><subject>Circadian Rhythm - physiology</subject><subject>Corticosterone - blood</subject><subject>Diet</subject><subject>dietary restriction</subject><subject>Endocrine Glands - physiology</subject><subject>Energy Intake</subject><subject>glucocorticoids</subject><subject>glycemia</subject><subject>Gompertz analysis</subject><subject>heat shock proteins</subject><subject>insulinemia</subject><subject>Male</subject><subject>metabolic rate</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Nervous System Physiological Phenomena</subject><subject>Phenotype</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UEtLAzEQDqLUWj15VfAkelidJJvHXgSpTyh40XPYTSYQ2XZrshX892bt0qOngZnvMd9HyBmFGwpU3oLgtBBCiquqvAYApgu2R6ZUK15ITcU-me4gh-Qopc8MkozTCZmoYQl6Sk4fAvZ1_LmImPoYbB-61TE58HWb8GScM_Lx9Pg-fykWb8-v8_tFYblQfSFqpSVK5Zi0leTSOU9d6ZV2Dq0StJFUo284Mu2xqhEsAIXGC84bL1nJZ-Ryq7uO3dcm-5tlSBbbtl5ht0lGKaFAljIDyy3Qxi6liN6sY1jmrw0FM3RhhqBmyGSq0vx1YVimnY_6m2aJbkcaw-f73faOOeR3wGiSDbiy6EJE2xvXhf8NfgG9K2wV</recordid><startdate>19950501</startdate><enddate>19950501</enddate><creator>Masoro, Edward J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950501</creationdate><title>Dietary restriction</title><author>Masoro, Edward J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-5a786e67d26c9636ddf1d4f78ddec751b618efb3e28fe9ae0c0010bf533bf6243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>biological age</topic><topic>Blood Glucose - metabolism</topic><topic>carbohydrate metabolism</topic><topic>Circadian Rhythm - physiology</topic><topic>Corticosterone - blood</topic><topic>Diet</topic><topic>dietary restriction</topic><topic>Endocrine Glands - physiology</topic><topic>Energy Intake</topic><topic>glucocorticoids</topic><topic>glycemia</topic><topic>Gompertz analysis</topic><topic>heat shock proteins</topic><topic>insulinemia</topic><topic>Male</topic><topic>metabolic rate</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Nervous System Physiological Phenomena</topic><topic>Phenotype</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masoro, Edward J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masoro, Edward J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary restriction</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>30</volume><issue>3</issue><spage>291</spage><epage>298</epage><pages>291-298</pages><issn>0531-5565</issn><eissn>1873-6815</eissn><abstract>Dietary restriction (DR) slows the rate of actuarial aging of rats and mice and in addition retards and/or delays many phenotypic characteristics of aging such as the age-associated deterioration of physiological systems and the occurrence and progression of age-associated disease. These antiaging actions result from a reduction of energy intake by the animal but are not due to a decrease in metabolic rate per unit of lean body mass. However, there is evidence that altered characteristics of fuel use (but not the intensity of fuel use) may underlie the antiaging action of DR. There is also evidence that DR has a general protective action in regard to damage caused by acute stressors; possibly a similar protective action in regard to damage caused by prolonged, low intensity aging processes plays a major role in the antiaging action of DR.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>7556508</pmid><doi>10.1016/0531-5565(94)00028-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0531-5565 |
| ispartof | Experimental gerontology, 1995-05, Vol.30 (3), p.291-298 |
| issn | 0531-5565 1873-6815 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77570646 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aging - physiology Animals biological age Blood Glucose - metabolism carbohydrate metabolism Circadian Rhythm - physiology Corticosterone - blood Diet dietary restriction Endocrine Glands - physiology Energy Intake glucocorticoids glycemia Gompertz analysis heat shock proteins insulinemia Male metabolic rate Mice Models, Biological Nervous System Physiological Phenomena Phenotype Rats Rats, Inbred F344 |
| title | Dietary restriction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T07%3A18%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20restriction&rft.jtitle=Experimental%20gerontology&rft.au=Masoro,%20Edward%20J.&rft.date=1995-05-01&rft.volume=30&rft.issue=3&rft.spage=291&rft.epage=298&rft.pages=291-298&rft.issn=0531-5565&rft.eissn=1873-6815&rft_id=info:doi/10.1016/0531-5565(94)00028-2&rft_dat=%3Cproquest_cross%3E77570646%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77570646&rft_id=info:pmid/7556508&rft_els_id=0531556594000282&rfr_iscdi=true |