Lymphocytic Na(+)-H+ exchange increases after an oral glucose challenge
The effects of oral glucose challenge on plasma glucose concentration, plasma insulin concentration, arterial blood pressure, cytosolic pH (pHi), cytosolic free Na+ concentration ([Na+]i), and cellular Na(+)-H+ exchange activity were investigated in 16 healthy subjects. The pHi, [Na+]i, and Na(+)-H+...
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| Veröffentlicht in: | Circulation research 1995-11, Vol.77 (5), p.1024-1029 |
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| creator | Tepel, M Schlotmann, R Barenbrock, M Kisters, K Klaus, T Spieker, C Walter, M Meyer, C Bretzel, R G Zidek, W |
| description | The effects of oral glucose challenge on plasma glucose concentration, plasma insulin concentration, arterial blood pressure, cytosolic pH (pHi), cytosolic free Na+ concentration ([Na+]i), and cellular Na(+)-H+ exchange activity were investigated in 16 healthy subjects. The pHi, [Na+]i, and Na(+)-H+ exchange activity were measured in intact lymphocytes by using the fluorescent dye technique. The oral glucose challenge significantly increased plasma glucose, plasma insulin, and the lymphocytic Na(+)-H+ exchange activity, measured as change of pHi per second (control [0 hours], 5.20 +/- 0.53 x 10(-3) dpHi/s; 1 hour after glucose administration, 8.28 +/- 1.07 x 10(-3) dpHi/s; 2 hours after glucose administration, 8.15 +/- 1.18 x 10(-3) dpHi/s; P = .002). The lymphocytic Na(+)-H+ exchange was significantly correlated with plasma glucose concentration (r = .357, P = .041). During steady state euglycemic hyperinsulinemic clamp, the Na(+)-H+ exchange activity was not significantly changed compared with baseline values. The study shows that changes of blood glucose levels can induce an acute increase in Na(+)-H+ exchange activity. Systolic blood pressure and Na(+)-H+ exchange activity were significantly (P < .001) but weakly correlated during an oral glucose challenge. |
| doi_str_mv | 10.1161/01.res.77.5.1024 |
| format | Article |
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The pHi, [Na+]i, and Na(+)-H+ exchange activity were measured in intact lymphocytes by using the fluorescent dye technique. The oral glucose challenge significantly increased plasma glucose, plasma insulin, and the lymphocytic Na(+)-H+ exchange activity, measured as change of pHi per second (control [0 hours], 5.20 +/- 0.53 x 10(-3) dpHi/s; 1 hour after glucose administration, 8.28 +/- 1.07 x 10(-3) dpHi/s; 2 hours after glucose administration, 8.15 +/- 1.18 x 10(-3) dpHi/s; P = .002). The lymphocytic Na(+)-H+ exchange was significantly correlated with plasma glucose concentration (r = .357, P = .041). During steady state euglycemic hyperinsulinemic clamp, the Na(+)-H+ exchange activity was not significantly changed compared with baseline values. The study shows that changes of blood glucose levels can induce an acute increase in Na(+)-H+ exchange activity. Systolic blood pressure and Na(+)-H+ exchange activity were significantly (P < .001) but weakly correlated during an oral glucose challenge.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.res.77.5.1024</identifier><identifier>PMID: 7554137</identifier><identifier>CODEN: CIRUAL</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins Ovid Technologies</publisher><subject>Adult ; Analysis of Variance ; Blood Glucose - analysis ; Blood Pressure ; Glucose Tolerance Test ; Humans ; Hydrogen-Ion Concentration ; Insulin - analysis ; Lymphocytes - metabolism ; Male ; Sodium - blood ; Sodium - metabolism ; Sodium-Hydrogen Exchangers - blood ; Sodium-Hydrogen Exchangers - metabolism ; Time Factors</subject><ispartof>Circulation research, 1995-11, Vol.77 (5), p.1024-1029</ispartof><rights>Copyright American Heart Association, Inc. Nov 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-7fd426a67201971061faf1b25820ca70793a1f125647eb40e424a791ce0a8be53</citedby><cites>FETCH-LOGICAL-c424t-7fd426a67201971061faf1b25820ca70793a1f125647eb40e424a791ce0a8be53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7554137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tepel, M</creatorcontrib><creatorcontrib>Schlotmann, R</creatorcontrib><creatorcontrib>Barenbrock, M</creatorcontrib><creatorcontrib>Kisters, K</creatorcontrib><creatorcontrib>Klaus, T</creatorcontrib><creatorcontrib>Spieker, C</creatorcontrib><creatorcontrib>Walter, M</creatorcontrib><creatorcontrib>Meyer, C</creatorcontrib><creatorcontrib>Bretzel, R G</creatorcontrib><creatorcontrib>Zidek, W</creatorcontrib><title>Lymphocytic Na(+)-H+ exchange increases after an oral glucose challenge</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>The effects of oral glucose challenge on plasma glucose concentration, plasma insulin concentration, arterial blood pressure, cytosolic pH (pHi), cytosolic free Na+ concentration ([Na+]i), and cellular Na(+)-H+ exchange activity were investigated in 16 healthy subjects. The pHi, [Na+]i, and Na(+)-H+ exchange activity were measured in intact lymphocytes by using the fluorescent dye technique. The oral glucose challenge significantly increased plasma glucose, plasma insulin, and the lymphocytic Na(+)-H+ exchange activity, measured as change of pHi per second (control [0 hours], 5.20 +/- 0.53 x 10(-3) dpHi/s; 1 hour after glucose administration, 8.28 +/- 1.07 x 10(-3) dpHi/s; 2 hours after glucose administration, 8.15 +/- 1.18 x 10(-3) dpHi/s; P = .002). The lymphocytic Na(+)-H+ exchange was significantly correlated with plasma glucose concentration (r = .357, P = .041). During steady state euglycemic hyperinsulinemic clamp, the Na(+)-H+ exchange activity was not significantly changed compared with baseline values. The study shows that changes of blood glucose levels can induce an acute increase in Na(+)-H+ exchange activity. Systolic blood pressure and Na(+)-H+ exchange activity were significantly (P < .001) but weakly correlated during an oral glucose challenge.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Blood Glucose - analysis</subject><subject>Blood Pressure</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Insulin - analysis</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Sodium - blood</subject><subject>Sodium - metabolism</subject><subject>Sodium-Hydrogen Exchangers - blood</subject><subject>Sodium-Hydrogen Exchangers - metabolism</subject><subject>Time Factors</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1Lw0AQRxdRaq3evQjBgyglcWazm22OUmorFAU_zstmO2lT0qTuJmD_e1NaPHiay_s9hsfYNUKEmOAjYOTIR0pFMkLg4oT1UXIRCqnwlPUBIA1VHMM5u_B-DYAi5mmP9ZSUAmPVZ9P5brNd1XbXFDZ4NffDh3A2DOjHrky1pKCorCPjyQcmb8gFpgpqZ8pgWba29hR0WFlSR16ys9yUnq6Od8C-nief41k4f5u-jJ_moRVcNKHKF4InJlEcMFUICeYmx4zLEQdrFKg0Npgjl4lQlAmgbmVUipbAjDKS8YDdHbxbV3-35Bu9KbylsjQV1a3XSskkjeWoA2__geu6dVX3m-bIBaQCoYPgAFlXe-8o11tXbIzbaQS9D6wB9fvko9NqqfeBu8nN0dtmG1r8DY5F419KAnO4</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>Tepel, M</creator><creator>Schlotmann, R</creator><creator>Barenbrock, M</creator><creator>Kisters, K</creator><creator>Klaus, T</creator><creator>Spieker, C</creator><creator>Walter, M</creator><creator>Meyer, C</creator><creator>Bretzel, R G</creator><creator>Zidek, W</creator><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>19951101</creationdate><title>Lymphocytic Na(+)-H+ exchange increases after an oral glucose challenge</title><author>Tepel, M ; 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The pHi, [Na+]i, and Na(+)-H+ exchange activity were measured in intact lymphocytes by using the fluorescent dye technique. The oral glucose challenge significantly increased plasma glucose, plasma insulin, and the lymphocytic Na(+)-H+ exchange activity, measured as change of pHi per second (control [0 hours], 5.20 +/- 0.53 x 10(-3) dpHi/s; 1 hour after glucose administration, 8.28 +/- 1.07 x 10(-3) dpHi/s; 2 hours after glucose administration, 8.15 +/- 1.18 x 10(-3) dpHi/s; P = .002). The lymphocytic Na(+)-H+ exchange was significantly correlated with plasma glucose concentration (r = .357, P = .041). During steady state euglycemic hyperinsulinemic clamp, the Na(+)-H+ exchange activity was not significantly changed compared with baseline values. The study shows that changes of blood glucose levels can induce an acute increase in Na(+)-H+ exchange activity. Systolic blood pressure and Na(+)-H+ exchange activity were significantly (P < .001) but weakly correlated during an oral glucose challenge.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins Ovid Technologies</pub><pmid>7554137</pmid><doi>10.1161/01.res.77.5.1024</doi><tpages>6</tpages></addata></record> |
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| ispartof | Circulation research, 1995-11, Vol.77 (5), p.1024-1029 |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Analysis of Variance Blood Glucose - analysis Blood Pressure Glucose Tolerance Test Humans Hydrogen-Ion Concentration Insulin - analysis Lymphocytes - metabolism Male Sodium - blood Sodium - metabolism Sodium-Hydrogen Exchangers - blood Sodium-Hydrogen Exchangers - metabolism Time Factors |
| title | Lymphocytic Na(+)-H+ exchange increases after an oral glucose challenge |
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