New Semisynthetic Glycopeptides MDL 63, 246 and MDL 63, 042, and Other Amide Derivatives of Antibiotic A-40, 926 Active against Highly Glycopeptide-resistant VanA Enterococci

A series of amide derivatives of natural glycopeptide A-40, 926 (A), its 6B-methyl ester (MA) and 6B-decarboxy-6B-hydroxymethyl derivative (RA) were prepared with the aim of obtaining activity against glycopeptide-resistant enterococci. These compounds are structurally related to a class of amides o...

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Veröffentlicht in:	Journal of antibiotics 1995/08/25, Vol.48(8), pp.869-883
Hauptverfasser:	MALABARBA, ADRIANO, CIABATTI, ROMEO, SCOTTI, ROBERTO, GOLDSTEIN, BETH P., FERRARI, PIETRO, KURZ, MICHAEL, ANDREINI, BIANCA P., DENARO, MAURIZIO
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Chromatography, High Pressure Liquid Drug Resistance, Microbial Enterococcus - drug effects Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments Structure-Activity Relationship Teicoplanin - analogs & derivatives Teicoplanin - chemical synthesis Teicoplanin - chemistry Teicoplanin - pharmacology Vancomycin - pharmacology
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