Carbohydrate type and amount alter intravascular processing and catabolism of plasma lipoproteins in guinea pigs
To test the effects of exchanging dietary complex and simple carbohydrate for fat calories on lipoprotein metabolism, guinea pigs were fed two different fat/carbohydrate ratios: 2.5∶58% (w/w) or 25∶29% (w/w) with either sucrose or starch as the carbohydrate source. Animals fed high‐fat had higher pl...
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| Veröffentlicht in: | Lipids 1995-07, Vol.30 (7), p.619-626 |
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| creator | Fernandez, M.L. (University of Arizona, Tucson, AZ.) Conde, A.K Ruiz, L.R Montano, C Ebner, J McNamara, D.J |
| description | To test the effects of exchanging dietary complex and simple carbohydrate for fat calories on lipoprotein metabolism, guinea pigs were fed two different fat/carbohydrate ratios: 2.5∶58% (w/w) or 25∶29% (w/w) with either sucrose or starch as the carbohydrate source. Animals fed high‐fat had higher plasma low‐density lipoprotein (LDL) and hepatic cholesterol concentrations than animals fed low‐fat diets (P |
| doi_str_mv | 10.1007/BF02536998 |
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(University of Arizona, Tucson, AZ.) ; Conde, A.K ; Ruiz, L.R ; Montano, C ; Ebner, J ; McNamara, D.J</creator><creatorcontrib>Fernandez, M.L. (University of Arizona, Tucson, AZ.) ; Conde, A.K ; Ruiz, L.R ; Montano, C ; Ebner, J ; McNamara, D.J</creatorcontrib><description>To test the effects of exchanging dietary complex and simple carbohydrate for fat calories on lipoprotein metabolism, guinea pigs were fed two different fat/carbohydrate ratios: 2.5∶58% (w/w) or 25∶29% (w/w) with either sucrose or starch as the carbohydrate source. Animals fed high‐fat had higher plasma low‐density lipoprotein (LDL) and hepatic cholesterol concentrations than animals fed low‐fat diets (P<0.01). The cholesteryl ester content per particle was higher, and the number of triacylglycerol (TAG) molecules was lower in very low density lipoprotein (VLDL) and LDL from animals fed high‐fat diets. Intake of high‐fat/sucrose resulted in higher plasma LDL concentrations than intake of high‐fat/starch, and animals fed low‐fat/starch had the highest plasma TAG concentrations associated with VLDL particles containing more TAG molecules, as well as a TAG‐enriched LDL. The activity of plasma lecithin cholesteryl:acyl transferase (LCAT) was highest in animals fed high‐fat/sucrose, and heart lipoprotein lipase (LPL) activity was higher in animals fed high‐fat diets. Hepatic apoprotein B/E (apo B/E) receptor number (Bmax) was increased 21% with low‐fat diets (P<0.01). These results suggest that the hypercholesterolemia induced by high‐fat and by sucrose intake are associated with a higher plasma LCAT activity which results in a cholesteryl ester‐enriched VLDL which, by the action of LPL, might be more readily converted to LDL through the delipidation cascade leading to downregulation of hepatic apo B/E receptors. The hypertriglyceridemia associated with low‐fat intake may result from increased production of VLDL TAG, which would explain the increased TAG content and the higher TAG/CE ratio of VLDL from animals fed the low‐fat/starch diet.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/BF02536998</identifier><identifier>PMID: 7564916</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>Animals ; Apolipoproteins B - blood ; BLOOD PLASMA ; CARBOHIDRATOS ; CARBOHYDRATES ; CATABOLISM ; CATABOLISME ; CATABOLISMO ; CHOLESTEROL ; Cholesterol - blood ; Cholesterol Esters - blood ; Cholesterol Esters - metabolism ; COBAYA ; COBAYE ; COLESTEROL ; CORPS GRAS ; DIET ; DIETA ; Dietary Carbohydrates - administration & dosage ; Dietary Carbohydrates - pharmacology ; Dietary Fats - administration & dosage ; Energy Intake ; FATS ; GLUCIDE ; GRASAS ; GUINEA PIGS ; Lipoprotein Lipase - metabolism ; LIPOPROTEINAS ; LIPOPROTEINE ; LIPOPROTEINS ; Lipoproteins - blood ; Lipoproteins, LDL - blood ; Lipoproteins, VLDL - blood ; Liver - metabolism ; Male ; Myocardium - enzymology ; Phosphatidylcholine-Sterol O-Acyltransferase - blood ; PLASMA SANGUIN ; PLASMA SANGUINEO ; Receptors, LDL - metabolism ; REGIME ALIMENTAIRE ; Starch - administration & dosage ; Sucrose - administration & dosage ; TRIACYLGLYCEROLS ; TRIGLICERIDOS ; TRIGLYCERIDE ; TRIGLYCERIDES ; Triglycerides - blood</subject><ispartof>Lipids, 1995-07, Vol.30 (7), p.619-626</ispartof><rights>1995 American Oil Chemists' Society (AOCS)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3429-ca87e67de6c26b534067b8d3cc2ce27a4082a4925ca0654b47d75dab131b8b553</citedby><cites>FETCH-LOGICAL-c3429-ca87e67de6c26b534067b8d3cc2ce27a4082a4925ca0654b47d75dab131b8b553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7564916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernandez, M.L. (University of Arizona, Tucson, AZ.)</creatorcontrib><creatorcontrib>Conde, A.K</creatorcontrib><creatorcontrib>Ruiz, L.R</creatorcontrib><creatorcontrib>Montano, C</creatorcontrib><creatorcontrib>Ebner, J</creatorcontrib><creatorcontrib>McNamara, D.J</creatorcontrib><title>Carbohydrate type and amount alter intravascular processing and catabolism of plasma lipoproteins in guinea pigs</title><title>Lipids</title><addtitle>Lipids</addtitle><description>To test the effects of exchanging dietary complex and simple carbohydrate for fat calories on lipoprotein metabolism, guinea pigs were fed two different fat/carbohydrate ratios: 2.5∶58% (w/w) or 25∶29% (w/w) with either sucrose or starch as the carbohydrate source. Animals fed high‐fat had higher plasma low‐density lipoprotein (LDL) and hepatic cholesterol concentrations than animals fed low‐fat diets (P<0.01). The cholesteryl ester content per particle was higher, and the number of triacylglycerol (TAG) molecules was lower in very low density lipoprotein (VLDL) and LDL from animals fed high‐fat diets. Intake of high‐fat/sucrose resulted in higher plasma LDL concentrations than intake of high‐fat/starch, and animals fed low‐fat/starch had the highest plasma TAG concentrations associated with VLDL particles containing more TAG molecules, as well as a TAG‐enriched LDL. The activity of plasma lecithin cholesteryl:acyl transferase (LCAT) was highest in animals fed high‐fat/sucrose, and heart lipoprotein lipase (LPL) activity was higher in animals fed high‐fat diets. Hepatic apoprotein B/E (apo B/E) receptor number (Bmax) was increased 21% with low‐fat diets (P<0.01). These results suggest that the hypercholesterolemia induced by high‐fat and by sucrose intake are associated with a higher plasma LCAT activity which results in a cholesteryl ester‐enriched VLDL which, by the action of LPL, might be more readily converted to LDL through the delipidation cascade leading to downregulation of hepatic apo B/E receptors. The hypertriglyceridemia associated with low‐fat intake may result from increased production of VLDL TAG, which would explain the increased TAG content and the higher TAG/CE ratio of VLDL from animals fed the low‐fat/starch diet.</description><subject>Animals</subject><subject>Apolipoproteins B - blood</subject><subject>BLOOD PLASMA</subject><subject>CARBOHIDRATOS</subject><subject>CARBOHYDRATES</subject><subject>CATABOLISM</subject><subject>CATABOLISME</subject><subject>CATABOLISMO</subject><subject>CHOLESTEROL</subject><subject>Cholesterol - blood</subject><subject>Cholesterol Esters - blood</subject><subject>Cholesterol Esters - metabolism</subject><subject>COBAYA</subject><subject>COBAYE</subject><subject>COLESTEROL</subject><subject>CORPS GRAS</subject><subject>DIET</subject><subject>DIETA</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Carbohydrates - pharmacology</subject><subject>Dietary Fats - administration & dosage</subject><subject>Energy Intake</subject><subject>FATS</subject><subject>GLUCIDE</subject><subject>GRASAS</subject><subject>GUINEA PIGS</subject><subject>Lipoprotein Lipase - metabolism</subject><subject>LIPOPROTEINAS</subject><subject>LIPOPROTEINE</subject><subject>LIPOPROTEINS</subject><subject>Lipoproteins - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Lipoproteins, VLDL - blood</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Myocardium - enzymology</subject><subject>Phosphatidylcholine-Sterol O-Acyltransferase - blood</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>Receptors, LDL - metabolism</subject><subject>REGIME ALIMENTAIRE</subject><subject>Starch - administration & dosage</subject><subject>Sucrose - administration & dosage</subject><subject>TRIACYLGLYCEROLS</subject><subject>TRIGLICERIDOS</subject><subject>TRIGLYCERIDE</subject><subject>TRIGLYCERIDES</subject><subject>Triglycerides - blood</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2LFDEQxcPiso67XvYoCDl5EFrznc5RR_cDBhTWPYdKOjNG0p026XaZ_94eZ9Cbp6J4v_eqeAhdU_KOEqLff7whTHJlTHuGVlTKtjGc6GdoRQgTjWCEPkcvav2xrFQYeYEutFTCULVC4xqKy9_3XYEp4Gk_BgxDh6HP8zBhSFMoOA5TgV9Q_Zyg4LFkH2qNw-4P6WECl1OsPc5bPCaoPeAUx7xwU4hDXex4N8chAB7jrl6h8y2kGl6e5iV6vPn8bX3XbL7c3q8_bBrPBTONh1YHpbugPFNOckGUdm3HvWc-MA2CtAyEYdIDUVI4oTstO3CUU9c6KfklenPMXf74OYc62T5WH1KCIeS5Wn2ogBizgG-PoC-51hK2diyxh7K3lNhDvfZfvQv8-pQ6uz50f9FTn4tOjvpTTGH_nyS7uf_6iSh6uP_qaNlCtrArsdrHByOXQM35b6NljSE</recordid><startdate>199507</startdate><enddate>199507</enddate><creator>Fernandez, M.L. (University of Arizona, Tucson, AZ.)</creator><creator>Conde, A.K</creator><creator>Ruiz, L.R</creator><creator>Montano, C</creator><creator>Ebner, J</creator><creator>McNamara, D.J</creator><general>Springer‐Verlag</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199507</creationdate><title>Carbohydrate type and amount alter intravascular processing and catabolism of plasma lipoproteins in guinea pigs</title><author>Fernandez, M.L. (University of Arizona, Tucson, AZ.) ; Conde, A.K ; Ruiz, L.R ; Montano, C ; Ebner, J ; McNamara, D.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3429-ca87e67de6c26b534067b8d3cc2ce27a4082a4925ca0654b47d75dab131b8b553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Apolipoproteins B - blood</topic><topic>BLOOD PLASMA</topic><topic>CARBOHIDRATOS</topic><topic>CARBOHYDRATES</topic><topic>CATABOLISM</topic><topic>CATABOLISME</topic><topic>CATABOLISMO</topic><topic>CHOLESTEROL</topic><topic>Cholesterol - blood</topic><topic>Cholesterol Esters - blood</topic><topic>Cholesterol Esters - metabolism</topic><topic>COBAYA</topic><topic>COBAYE</topic><topic>COLESTEROL</topic><topic>CORPS GRAS</topic><topic>DIET</topic><topic>DIETA</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Dietary Carbohydrates - pharmacology</topic><topic>Dietary Fats - administration & dosage</topic><topic>Energy Intake</topic><topic>FATS</topic><topic>GLUCIDE</topic><topic>GRASAS</topic><topic>GUINEA PIGS</topic><topic>Lipoprotein Lipase - metabolism</topic><topic>LIPOPROTEINAS</topic><topic>LIPOPROTEINE</topic><topic>LIPOPROTEINS</topic><topic>Lipoproteins - blood</topic><topic>Lipoproteins, LDL - blood</topic><topic>Lipoproteins, VLDL - blood</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Myocardium - enzymology</topic><topic>Phosphatidylcholine-Sterol O-Acyltransferase - blood</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>Receptors, LDL - metabolism</topic><topic>REGIME ALIMENTAIRE</topic><topic>Starch - administration & dosage</topic><topic>Sucrose - administration & dosage</topic><topic>TRIACYLGLYCEROLS</topic><topic>TRIGLICERIDOS</topic><topic>TRIGLYCERIDE</topic><topic>TRIGLYCERIDES</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernandez, M.L. (University of Arizona, Tucson, AZ.)</creatorcontrib><creatorcontrib>Conde, A.K</creatorcontrib><creatorcontrib>Ruiz, L.R</creatorcontrib><creatorcontrib>Montano, C</creatorcontrib><creatorcontrib>Ebner, J</creatorcontrib><creatorcontrib>McNamara, D.J</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernandez, M.L. (University of Arizona, Tucson, AZ.)</au><au>Conde, A.K</au><au>Ruiz, L.R</au><au>Montano, C</au><au>Ebner, J</au><au>McNamara, D.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbohydrate type and amount alter intravascular processing and catabolism of plasma lipoproteins in guinea pigs</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>1995-07</date><risdate>1995</risdate><volume>30</volume><issue>7</issue><spage>619</spage><epage>626</epage><pages>619-626</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>To test the effects of exchanging dietary complex and simple carbohydrate for fat calories on lipoprotein metabolism, guinea pigs were fed two different fat/carbohydrate ratios: 2.5∶58% (w/w) or 25∶29% (w/w) with either sucrose or starch as the carbohydrate source. Animals fed high‐fat had higher plasma low‐density lipoprotein (LDL) and hepatic cholesterol concentrations than animals fed low‐fat diets (P<0.01). The cholesteryl ester content per particle was higher, and the number of triacylglycerol (TAG) molecules was lower in very low density lipoprotein (VLDL) and LDL from animals fed high‐fat diets. Intake of high‐fat/sucrose resulted in higher plasma LDL concentrations than intake of high‐fat/starch, and animals fed low‐fat/starch had the highest plasma TAG concentrations associated with VLDL particles containing more TAG molecules, as well as a TAG‐enriched LDL. The activity of plasma lecithin cholesteryl:acyl transferase (LCAT) was highest in animals fed high‐fat/sucrose, and heart lipoprotein lipase (LPL) activity was higher in animals fed high‐fat diets. Hepatic apoprotein B/E (apo B/E) receptor number (Bmax) was increased 21% with low‐fat diets (P<0.01). These results suggest that the hypercholesterolemia induced by high‐fat and by sucrose intake are associated with a higher plasma LCAT activity which results in a cholesteryl ester‐enriched VLDL which, by the action of LPL, might be more readily converted to LDL through the delipidation cascade leading to downregulation of hepatic apo B/E receptors. The hypertriglyceridemia associated with low‐fat intake may result from increased production of VLDL TAG, which would explain the increased TAG content and the higher TAG/CE ratio of VLDL from animals fed the low‐fat/starch diet.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>7564916</pmid><doi>10.1007/BF02536998</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Lipids, 1995-07, Vol.30 (7), p.619-626 |
| issn | 0024-4201 1558-9307 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Apolipoproteins B - blood BLOOD PLASMA CARBOHIDRATOS CARBOHYDRATES CATABOLISM CATABOLISME CATABOLISMO CHOLESTEROL Cholesterol - blood Cholesterol Esters - blood Cholesterol Esters - metabolism COBAYA COBAYE COLESTEROL CORPS GRAS DIET DIETA Dietary Carbohydrates - administration & dosage Dietary Carbohydrates - pharmacology Dietary Fats - administration & dosage Energy Intake FATS GLUCIDE GRASAS GUINEA PIGS Lipoprotein Lipase - metabolism LIPOPROTEINAS LIPOPROTEINE LIPOPROTEINS Lipoproteins - blood Lipoproteins, LDL - blood Lipoproteins, VLDL - blood Liver - metabolism Male Myocardium - enzymology Phosphatidylcholine-Sterol O-Acyltransferase - blood PLASMA SANGUIN PLASMA SANGUINEO Receptors, LDL - metabolism REGIME ALIMENTAIRE Starch - administration & dosage Sucrose - administration & dosage TRIACYLGLYCEROLS TRIGLICERIDOS TRIGLYCERIDE TRIGLYCERIDES Triglycerides - blood |
| title | Carbohydrate type and amount alter intravascular processing and catabolism of plasma lipoproteins in guinea pigs |
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