Penetration of DGAVP (Org 5667) across the blood-brain barrier in human subjects

To assess the penetration of desglycinamide-arginine-vasopressin (DGAVP, Org 5667) to the central nervous system, levels of DGAVP were measured in the lumbar CSF after peripheral administration. DGAVP (2 mg) was administered intranasally to 37 patients and CSF samples were collected from these patie...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1987-03, Vol.8 (2), p.261-265
Hauptverfasser:	Riekkinen, Paavo, Legros, Jean-Jacques, Sennef, Cor, Jolkkonen, Jukka, Smitz, Simon, Soininen, Hilkka
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Adult Aged Arginine Vasopressin - administration & dosage Arginine Vasopressin - analogs & derivatives Arginine Vasopressin - cerebrospinal fluid Arginine Vasopressin - metabolism Biological and medical sciences Blood-Brain Barrier Cerebrospinal fluid Female Human subjects Humans Kinetics Male Medical sciences Middle Aged Miscellaneous Nervous System Diseases - cerebrospinal fluid Nervous System Diseases - metabolism Neuropharmacology Pharmacology. Drug treatments Vasopressin analogue
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