Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice
Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma–like conditions in animals. F 1 mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma–like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian...
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| Veröffentlicht in: | Nature genetics 1995-10, Vol.11 (2), p.150-154 |
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| container_title | Nature genetics |
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| creator | De Sanctis, George T. Merchant, Mark Beier, David R. Dredge, Robert D. Grobholz, James K. Martin, Thomas R. Lander, Eric S. Drazen, Jeffrey M. |
| description | Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma–like conditions in animals. F
1
mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma–like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci,
Bhr1
(lod = 3.0) and
Bhr2
(lod = 3.7) on chromosomes 2 and 15. A third locus,
Bhr3
(lod = 2.83), maps to chromosome 17. Each of these loci maps near candidate loci implicated in the pathobiology of asthma. Our study represents the first linkages established through a genome–wide survey of airway hyperresponsiveness in any mammal. |
| doi_str_mv | 10.1038/ng1095-150 |
| format | Article |
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1
mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma–like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci,
Bhr1
(lod = 3.0) and
Bhr2
(lod = 3.7) on chromosomes 2 and 15. A third locus,
Bhr3
(lod = 2.83), maps to chromosome 17. Each of these loci maps near candidate loci implicated in the pathobiology of asthma. Our study represents the first linkages established through a genome–wide survey of airway hyperresponsiveness in any mammal.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng1095-150</identifier><identifier>PMID: 7550342</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Analysis of Variance ; Animal Genetics and Genomics ; Animals ; Asthma - genetics ; Asthma - physiopathology ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Chromosome Mapping ; Classical genetics, quantitative genetics, hybrids ; Crosses, Genetic ; DNA - analysis ; DNA - isolation & purification ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Function ; Genetic Linkage ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype ; Human Genetics ; Humans ; Kidney - metabolism ; Lod Score ; Lung - drug effects ; Lung - physiology ; Male ; Mammals ; Methacholine Chloride - pharmacology ; Mice ; Mice, Inbred A ; Mice, Inbred C57BL ; Parasympathomimetics - pharmacology ; Phenotype ; Plethysmography ; Polymerase Chain Reaction ; Respiratory Function Tests ; Vertebrata</subject><ispartof>Nature genetics, 1995-10, Vol.11 (2), p.150-154</ispartof><rights>Springer Nature America, Inc. 1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-e89f7d777db041171d809ae4c292924f9f67bb7b2d43cfea02106291f2e33a573</citedby><cites>FETCH-LOGICAL-c413t-e89f7d777db041171d809ae4c292924f9f67bb7b2d43cfea02106291f2e33a573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng1095-150$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng1095-150$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3679242$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7550342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Sanctis, George T.</creatorcontrib><creatorcontrib>Merchant, Mark</creatorcontrib><creatorcontrib>Beier, David R.</creatorcontrib><creatorcontrib>Dredge, Robert D.</creatorcontrib><creatorcontrib>Grobholz, James K.</creatorcontrib><creatorcontrib>Martin, Thomas R.</creatorcontrib><creatorcontrib>Lander, Eric S.</creatorcontrib><creatorcontrib>Drazen, Jeffrey M.</creatorcontrib><title>Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma–like conditions in animals. F
1
mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma–like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci,
Bhr1
(lod = 3.0) and
Bhr2
(lod = 3.7) on chromosomes 2 and 15. A third locus,
Bhr3
(lod = 2.83), maps to chromosome 17. Each of these loci maps near candidate loci implicated in the pathobiology of asthma. Our study represents the first linkages established through a genome–wide survey of airway hyperresponsiveness in any mammal.</description><subject>Agriculture</subject><subject>Analysis of Variance</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Asthma - genetics</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Chromosome Mapping</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Crosses, Genetic</subject><subject>DNA - analysis</subject><subject>DNA - isolation & purification</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Function</subject><subject>Genetic Linkage</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Kidney - metabolism</subject><subject>Lod Score</subject><subject>Lung - drug effects</subject><subject>Lung - physiology</subject><subject>Male</subject><subject>Mammals</subject><subject>Methacholine Chloride - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred A</subject><subject>Mice, Inbred C57BL</subject><subject>Parasympathomimetics - pharmacology</subject><subject>Phenotype</subject><subject>Plethysmography</subject><subject>Polymerase Chain Reaction</subject><subject>Respiratory Function Tests</subject><subject>Vertebrata</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1LwzAYh4Moc35cvAs5iAelLmnSpj3O4dcYiKLnkqbJzGjTmbdV9t-bsbKT5PAGfg_vx4PQBSV3lLBs4paU5ElEE3KAxjThaUQFzQ7Dn6Q04oSlx-gEYEUI5ZxkIzQSSUIYj8fo_a2XrrOd7OyPxnWresDSyXoDFnBrsLT-V27w12atvdewbh0E0GkAbB2eTuaBrvAsEfeLSTrHjVX6DB0ZWYM-H-op-nx8-Jg9R4vXp5fZdBEpTlkX6Sw3ohJCVCXhNCxcZSSXmqs4D4-b3KSiLEUZV5wpoyWJwzVxTk2sGZOJYKfoetd37dvvXkNXNBaUrmvpdNtDIUSSxozkAbzZgcq3AF6bYu1tI_2moKTYCix2AosgMMCXQ9e-bHS1RwdjIb8acglK1sZLpyzsMZaKsPwWu91hEBK31L5Ytb0PYuG_oX-ZPYR9</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>De Sanctis, George T.</creator><creator>Merchant, Mark</creator><creator>Beier, David R.</creator><creator>Dredge, Robert D.</creator><creator>Grobholz, James K.</creator><creator>Martin, Thomas R.</creator><creator>Lander, Eric S.</creator><creator>Drazen, Jeffrey M.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951001</creationdate><title>Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice</title><author>De Sanctis, George T. ; Merchant, Mark ; Beier, David R. ; Dredge, Robert D. ; Grobholz, James K. ; Martin, Thomas R. ; Lander, Eric S. ; Drazen, Jeffrey M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-e89f7d777db041171d809ae4c292924f9f67bb7b2d43cfea02106291f2e33a573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Agriculture</topic><topic>Analysis of Variance</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Asthma - genetics</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Chromosome Mapping</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Crosses, Genetic</topic><topic>DNA - analysis</topic><topic>DNA - isolation & purification</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Function</topic><topic>Genetic Linkage</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genotype</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Kidney - metabolism</topic><topic>Lod Score</topic><topic>Lung - drug effects</topic><topic>Lung - physiology</topic><topic>Male</topic><topic>Mammals</topic><topic>Methacholine Chloride - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred A</topic><topic>Mice, Inbred C57BL</topic><topic>Parasympathomimetics - pharmacology</topic><topic>Phenotype</topic><topic>Plethysmography</topic><topic>Polymerase Chain Reaction</topic><topic>Respiratory Function Tests</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Sanctis, George T.</creatorcontrib><creatorcontrib>Merchant, Mark</creatorcontrib><creatorcontrib>Beier, David R.</creatorcontrib><creatorcontrib>Dredge, Robert D.</creatorcontrib><creatorcontrib>Grobholz, James K.</creatorcontrib><creatorcontrib>Martin, Thomas R.</creatorcontrib><creatorcontrib>Lander, Eric S.</creatorcontrib><creatorcontrib>Drazen, Jeffrey M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Sanctis, George T.</au><au>Merchant, Mark</au><au>Beier, David R.</au><au>Dredge, Robert D.</au><au>Grobholz, James K.</au><au>Martin, Thomas R.</au><au>Lander, Eric S.</au><au>Drazen, Jeffrey M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>11</volume><issue>2</issue><spage>150</spage><epage>154</epage><pages>150-154</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma–like conditions in animals. F
1
mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma–like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci,
Bhr1
(lod = 3.0) and
Bhr2
(lod = 3.7) on chromosomes 2 and 15. A third locus,
Bhr3
(lod = 2.83), maps to chromosome 17. Each of these loci maps near candidate loci implicated in the pathobiology of asthma. Our study represents the first linkages established through a genome–wide survey of airway hyperresponsiveness in any mammal.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>7550342</pmid><doi>10.1038/ng1095-150</doi><tpages>5</tpages></addata></record> |
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| subjects | Agriculture Analysis of Variance Animal Genetics and Genomics Animals Asthma - genetics Asthma - physiopathology Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Chromosome Mapping Classical genetics, quantitative genetics, hybrids Crosses, Genetic DNA - analysis DNA - isolation & purification Female Fundamental and applied biological sciences. Psychology Gene Function Genetic Linkage Genetics of eukaryotes. Biological and molecular evolution Genotype Human Genetics Humans Kidney - metabolism Lod Score Lung - drug effects Lung - physiology Male Mammals Methacholine Chloride - pharmacology Mice Mice, Inbred A Mice, Inbred C57BL Parasympathomimetics - pharmacology Phenotype Plethysmography Polymerase Chain Reaction Respiratory Function Tests Vertebrata |
| title | Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice |
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