Inhibition of lymphocyte nucleic acid metabolism and antibody production by trimetrexate

Trimetrexate is a lipid soluble dihydrofolate reductase inhibitor which, unlike methotrexate, does not depend upon the membrane folate transport system for cell entry. We investigated the possibility that trimetrexate (but not methotrexate) might permeate intermitotic lymphocytes and, following stim...

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Veröffentlicht in:	Biochemical pharmacology 1987-05, Vol.36 (10), p.1605-1612
Hauptverfasser:	Branda, Richard F., Carney, Jan K., Perlmutter, Carol A., Moore, Ann L., McCormack, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody Formation - drug effects Antineoplastic agents Biological and medical sciences Deoxyuridine - blood DNA - biosynthesis General aspects Humans Interphase - drug effects Lymphocytes - drug effects Lymphocytes - immunology Lymphocytes - metabolism Medical sciences Methotrexate - pharmacology Nucleic Acids - blood Pharmacology. Drug treatments Quinazolines - pharmacology Thymidine - blood Trimetrexate
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