Characterization of 5-Hydroxytryptamine receptors in goat cerebral arteries

1. 1. In isolated goat middle cerebral artery segments, 5-hydroxytryptamine (5-HT, 10 −8-3 × 10 −5 M) elicited concentration-dependent contractions with EC 50 = 2.1 (1.9−2.5) × 10 −7 M and E max = 64 ± 2% of 50 mM KCl-induced contraction. 2. 2. Several 5-HT receptor agonists were used: (a) the agoni...

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