$Comparison of nuclear 5α-reductase activities in the stromal and epithelial fractions of human prostatic tissue$

Comparison of nuclear 5α-reductase activities in the stromal and epithelial fractions of human prostatic tissue

The nuclear conversion of testosterone (T) to dihydrotestosterone (DHT) was compared in the separated stromal and epithelial fractions of hyperplastic ( n = 20), malignant ( n = 5) and normal ( n = 1) prostatic tissues. Standard assay conditions were: 1 μM testosterone, plus 4–6 × 10 5DPM [ 3H]T, 1....

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Veröffentlicht in:	Journal of steroid biochemistry 1987-03, Vol.26 (3), p.349-353
1. Verfasser:	Hudson, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism Biological and medical sciences Cell Nucleus - enzymology Dihydrotestosterone - metabolism Edetic Acid - pharmacology Epithelium - enzymology Fundamental and applied biological sciences. Psychology Humans Hydrogen-Ion Concentration Kinetics Male Prostate - enzymology Prostatic Hyperplasia - enzymology Prostatic Neoplasms - enzymology Steroid hormones. Cholecalciferol derivatives Testosterone - metabolism Vertebrates: endocrinology Zinc - pharmacology
Online-Zugang:	Volltext
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