HIV antigen in the brains of patients with the AIDS dementia complex
Human immunodeficiency virus infection was identified immunohistochemically in the brains of 8 patients with acquired immune deficiency syndrome dementia complex. Using a monoclonal antibody against a structural viral protein (p25), infection was detected in white matter and basal ganglia in a distr...
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| Veröffentlicht in: | Annals of neurology 1987-05, Vol.21 (5), p.490-496 |
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| container_end_page | 496 |
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| container_issue | 5 |
| container_start_page | 490 |
| container_title | Annals of neurology |
| container_volume | 21 |
| creator | Pumarola-Sune, Tomas Navia, Bradford A. Price, Richard W. Cordon-Cardo, Carlos Cho, Eun-Sook |
| description | Human immunodeficiency virus infection was identified immunohistochemically in the brains of 8 patients with acquired immune deficiency syndrome dementia complex. Using a monoclonal antibody against a structural viral protein (p25), infection was detected in white matter and basal ganglia in a distribution paralleling that of the major neuropathological abnormalities. Viral antigen was identified principally in perivascular and parenchymal macrophages and in multinucleated cells of macrophage origin that were identified morphologically and by immunocytochemical staining for acid phsophatase isozyme. In 4 of the 8 patients, viral antigen was also detected in acid‐phosphatase–negative, process‐bearing neuroglial cells; in 2 patients, antigen was detected in basal ganglion cells that were morphologically consistent with neurons and in alkaline‐phosphatase–positive cells with elongated nuclei that were most likely of endothelial origin. |
| doi_str_mv | 10.1002/ana.410210513 |
| format | Article |
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Using a monoclonal antibody against a structural viral protein (p25), infection was detected in white matter and basal ganglia in a distribution paralleling that of the major neuropathological abnormalities. Viral antigen was identified principally in perivascular and parenchymal macrophages and in multinucleated cells of macrophage origin that were identified morphologically and by immunocytochemical staining for acid phsophatase isozyme. In 4 of the 8 patients, viral antigen was also detected in acid‐phosphatase–negative, process‐bearing neuroglial cells; in 2 patients, antigen was detected in basal ganglion cells that were morphologically consistent with neurons and in alkaline‐phosphatase–positive cells with elongated nuclei that were most likely of endothelial origin.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.410210513</identifier><identifier>PMID: 3296948</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Acquired Immunodeficiency Syndrome - pathology ; Adult ; AIDS/HIV ; Antibodies, Monoclonal ; Antigens, Viral - analysis ; Basal Ganglia - pathology ; Biological and medical sciences ; Brain - pathology ; Cerebral Cortex - pathology ; Child, Preschool ; Dementia - pathology ; Female ; HIV Antigens ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunoenzyme Techniques ; Immunopathology ; Macrophages - pathology ; Male ; Medical sciences ; Middle Aged ; Neuroglia - pathology ; Neurons - pathology</subject><ispartof>Annals of neurology, 1987-05, Vol.21 (5), p.490-496</ispartof><rights>Copyright © 1987 American Neurological Association</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4323-745b76b4aa288f4c6c8aa109ac7ff4944c41b91cad3fb9701bbcb2031df7f2153</citedby><cites>FETCH-LOGICAL-c4323-745b76b4aa288f4c6c8aa109ac7ff4944c41b91cad3fb9701bbcb2031df7f2153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.410210513$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.410210513$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8235700$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3296948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pumarola-Sune, Tomas</creatorcontrib><creatorcontrib>Navia, Bradford A.</creatorcontrib><creatorcontrib>Price, Richard W.</creatorcontrib><creatorcontrib>Cordon-Cardo, Carlos</creatorcontrib><creatorcontrib>Cho, Eun-Sook</creatorcontrib><title>HIV antigen in the brains of patients with the AIDS dementia complex</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Human immunodeficiency virus infection was identified immunohistochemically in the brains of 8 patients with acquired immune deficiency syndrome dementia complex. Using a monoclonal antibody against a structural viral protein (p25), infection was detected in white matter and basal ganglia in a distribution paralleling that of the major neuropathological abnormalities. Viral antigen was identified principally in perivascular and parenchymal macrophages and in multinucleated cells of macrophage origin that were identified morphologically and by immunocytochemical staining for acid phsophatase isozyme. In 4 of the 8 patients, viral antigen was also detected in acid‐phosphatase–negative, process‐bearing neuroglial cells; in 2 patients, antigen was detected in basal ganglion cells that were morphologically consistent with neurons and in alkaline‐phosphatase–positive cells with elongated nuclei that were most likely of endothelial origin.</description><subject>Acquired Immunodeficiency Syndrome - pathology</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Antibodies, Monoclonal</subject><subject>Antigens, Viral - analysis</subject><subject>Basal Ganglia - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Cerebral Cortex - pathology</subject><subject>Child, Preschool</subject><subject>Dementia - pathology</subject><subject>Female</subject><subject>HIV Antigens</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoenzyme Techniques</subject><subject>Immunopathology</subject><subject>Macrophages - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuroglia - pathology</subject><subject>Neurons - pathology</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElPwzAQhS0EgrIcOSL5gLgFvCVOjqVslSp2isTFGrs2GLKUOFXLvyfQqOLEaaR538y8eQjtU3JMCWEnUMKxoIRRElO-hno05jRKmcjWUY_wRERtW2yh7RDeCSFZQskm2uQsSzKR9tDZ1XCMoWz8qy2xL3HzZrGuwZcBVw5PofG2bAKe--btV-sPzx7wxBZt1wM2VTHN7WIXbTjIg93r6g56ujh_HFxFo5vL4aA_iozgjEdSxFomWgCwNHXCJCYFoCQDI50TmRBGUJ1RAxPudCYJ1dpoRjidOOlY-9cOOlrundbV58yGRhU-GJvnUNpqFpSUccxFkrRgtARNXYVQW6emtS-g_lKUqJ_UVJuaWqXW8gfd4pku7GRFdzG1-mGnQzCQuxpK48MKSxmPJSEtJpfY3Of26_-bqn_d_2ugM-xDYxerSag_VCK5jNXz9aV6ubt9YeL0Xo35NwM7koU</recordid><startdate>198705</startdate><enddate>198705</enddate><creator>Pumarola-Sune, Tomas</creator><creator>Navia, Bradford A.</creator><creator>Price, Richard W.</creator><creator>Cordon-Cardo, Carlos</creator><creator>Cho, Eun-Sook</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198705</creationdate><title>HIV antigen in the brains of patients with the AIDS dementia complex</title><author>Pumarola-Sune, Tomas ; Navia, Bradford A. ; Price, Richard W. ; Cordon-Cardo, Carlos ; Cho, Eun-Sook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4323-745b76b4aa288f4c6c8aa109ac7ff4944c41b91cad3fb9701bbcb2031df7f2153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Acquired Immunodeficiency Syndrome - pathology</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Antibodies, Monoclonal</topic><topic>Antigens, Viral - analysis</topic><topic>Basal Ganglia - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Cerebral Cortex - pathology</topic><topic>Child, Preschool</topic><topic>Dementia - pathology</topic><topic>Female</topic><topic>HIV Antigens</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoenzyme Techniques</topic><topic>Immunopathology</topic><topic>Macrophages - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuroglia - pathology</topic><topic>Neurons - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pumarola-Sune, Tomas</creatorcontrib><creatorcontrib>Navia, Bradford A.</creatorcontrib><creatorcontrib>Price, Richard W.</creatorcontrib><creatorcontrib>Cordon-Cardo, Carlos</creatorcontrib><creatorcontrib>Cho, Eun-Sook</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pumarola-Sune, Tomas</au><au>Navia, Bradford A.</au><au>Price, Richard W.</au><au>Cordon-Cardo, Carlos</au><au>Cho, Eun-Sook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV antigen in the brains of patients with the AIDS dementia complex</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1987-05</date><risdate>1987</risdate><volume>21</volume><issue>5</issue><spage>490</spage><epage>496</epage><pages>490-496</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>Human immunodeficiency virus infection was identified immunohistochemically in the brains of 8 patients with acquired immune deficiency syndrome dementia complex. Using a monoclonal antibody against a structural viral protein (p25), infection was detected in white matter and basal ganglia in a distribution paralleling that of the major neuropathological abnormalities. Viral antigen was identified principally in perivascular and parenchymal macrophages and in multinucleated cells of macrophage origin that were identified morphologically and by immunocytochemical staining for acid phsophatase isozyme. In 4 of the 8 patients, viral antigen was also detected in acid‐phosphatase–negative, process‐bearing neuroglial cells; in 2 patients, antigen was detected in basal ganglion cells that were morphologically consistent with neurons and in alkaline‐phosphatase–positive cells with elongated nuclei that were most likely of endothelial origin.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3296948</pmid><doi>10.1002/ana.410210513</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-5134 |
| ispartof | Annals of neurology, 1987-05, Vol.21 (5), p.490-496 |
| issn | 0364-5134 1531-8249 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Acquired Immunodeficiency Syndrome - pathology Adult AIDS/HIV Antibodies, Monoclonal Antigens, Viral - analysis Basal Ganglia - pathology Biological and medical sciences Brain - pathology Cerebral Cortex - pathology Child, Preschool Dementia - pathology Female HIV Antigens Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoenzyme Techniques Immunopathology Macrophages - pathology Male Medical sciences Middle Aged Neuroglia - pathology Neurons - pathology |
| title | HIV antigen in the brains of patients with the AIDS dementia complex |
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