Effect of passive maternal antibody on influenza illness in children: a prospective study of influenza A in mother-infant pairs
To determine the effect of passive antibody on the incidence of influenza in infants, infants born to mothers with serum antibody to influenza A (immune) and those born to mothers without evidence for this serum antibody (nonimmune) were followed during the influenza H1N1 epidemic of 1979. Immune mo...
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| Veröffentlicht in: | The Pediatric infectious disease journal 1987-04, Vol.6 (4), p.398-403 |
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| creator | REUMAN, PETER D AYOUB, ELIA M SMALL, PARKER A |
| description | To determine the effect of passive antibody on the incidence of influenza in infants, infants born to mothers with serum antibody to influenza A (immune) and those born to mothers without evidence for this serum antibody (nonimmune) were followed during the influenza H1N1 epidemic of 1979. Immune mothers had higher H1-specific antibody titers before the epidemic (P < 0.001), were less frequently culture positive, showed fewer titer rises (P < 0.001) and were less symptomatic than were nonimmune mothers. Infants of immune mothers had higher H1-specific passive antibody titers that correlated with their motherʼs antibody titers. Although infants of both groups showed no difference in incidence of influenza infection, infants of immune mothers had influenza symptoms that were delayed in onset (P = 0.02) and were of shorter mean duration compared with infants of nonimmune mothers. These findings suggest that passive maternal antibody delays the onset and decreases the severity of influenza disease in young infants. |
| doi_str_mv | 10.1097/00006454-198704000-00011 |
| format | Article |
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Immune mothers had higher H1-specific antibody titers before the epidemic (P < 0.001), were less frequently culture positive, showed fewer titer rises (P < 0.001) and were less symptomatic than were nonimmune mothers. Infants of immune mothers had higher H1-specific passive antibody titers that correlated with their motherʼs antibody titers. Although infants of both groups showed no difference in incidence of influenza infection, infants of immune mothers had influenza symptoms that were delayed in onset (P = 0.02) and were of shorter mean duration compared with infants of nonimmune mothers. These findings suggest that passive maternal antibody delays the onset and decreases the severity of influenza disease in young infants.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/00006454-198704000-00011</identifier><identifier>PMID: 3588113</identifier><language>eng</language><publisher>United States: Williams & Wilkins</publisher><subject>Antibodies, Viral - analysis ; Female ; Humans ; Immunity, Maternally-Acquired ; Infant ; Influenza A virus - immunology ; Influenza A virus - isolation & purification ; Influenza, Human - immunology ; Pregnancy ; Prospective Studies</subject><ispartof>The Pediatric infectious disease journal, 1987-04, Vol.6 (4), p.398-403</ispartof><rights>Williams & Wilkins 1987. 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These findings suggest that passive maternal antibody delays the onset and decreases the severity of influenza disease in young infants.</description><subject>Antibodies, Viral - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity, Maternally-Acquired</subject><subject>Infant</subject><subject>Influenza A virus - immunology</subject><subject>Influenza A virus - isolation & purification</subject><subject>Influenza, Human - immunology</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UcFu3CAQRVWqdJP0Eypx6s0NY2CNe4uiJI0UqZf2jDAMWrfY3oKdKLnk1zub3US9FAkh3rz3hnkwxkF8AdE254LWWmlVQWsaoehW0QZ4x1agZV0Jgo_YSpgWKrlemw_spJRfRJEKxDE7ltoYALliz1cxop_5FPnWldLfIx_cjHl0ibtx7rspPPJp5P0Y04Ljk-N9SiOWQgj3mz6FjONX7vg2T2VLTjuHMi87VfxHdbHjD9O8wVwRStbUr8_ljL2PLhX8eDhP2c_rqx-X36q77ze3lxd3lVc1QNXo2GGIrulAQXDeNWCE1-DRm8YEFKrtQGiaNEIwIGXdxrbzIXQ1SnRKnrLPe196558Fy2yHvnhMyY04LcU2jdZS6ZqIZk_0NFDJGO0294PLjxaE3WVvX7O3b9nbl-xJ-unQY-kGDG_CQ9hUV_v6w5Qo4vI7LQ-Y7QZdmjf2f18q_wKZIZFR</recordid><startdate>198704</startdate><enddate>198704</enddate><creator>REUMAN, PETER D</creator><creator>AYOUB, ELIA M</creator><creator>SMALL, PARKER A</creator><general>Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198704</creationdate><title>Effect of passive maternal antibody on influenza illness in children: a prospective study of influenza A in mother-infant pairs</title><author>REUMAN, PETER D ; AYOUB, ELIA M ; SMALL, PARKER A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4211-75fbedfa7b141daca7180c51cec878de049b105668f1d813329f9bcddb2e3ea43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Antibodies, Viral - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Immunity, Maternally-Acquired</topic><topic>Infant</topic><topic>Influenza A virus - immunology</topic><topic>Influenza A virus - isolation & purification</topic><topic>Influenza, Human - immunology</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>REUMAN, PETER D</creatorcontrib><creatorcontrib>AYOUB, ELIA M</creatorcontrib><creatorcontrib>SMALL, PARKER A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>REUMAN, PETER D</au><au>AYOUB, ELIA M</au><au>SMALL, PARKER A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of passive maternal antibody on influenza illness in children: a prospective study of influenza A in mother-infant pairs</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>1987-04</date><risdate>1987</risdate><volume>6</volume><issue>4</issue><spage>398</spage><epage>403</epage><pages>398-403</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><abstract>To determine the effect of passive antibody on the incidence of influenza in infants, infants born to mothers with serum antibody to influenza A (immune) and those born to mothers without evidence for this serum antibody (nonimmune) were followed during the influenza H1N1 epidemic of 1979. Immune mothers had higher H1-specific antibody titers before the epidemic (P < 0.001), were less frequently culture positive, showed fewer titer rises (P < 0.001) and were less symptomatic than were nonimmune mothers. Infants of immune mothers had higher H1-specific passive antibody titers that correlated with their motherʼs antibody titers. Although infants of both groups showed no difference in incidence of influenza infection, infants of immune mothers had influenza symptoms that were delayed in onset (P = 0.02) and were of shorter mean duration compared with infants of nonimmune mothers. These findings suggest that passive maternal antibody delays the onset and decreases the severity of influenza disease in young infants.</abstract><cop>United States</cop><pub>Williams & Wilkins</pub><pmid>3588113</pmid><doi>10.1097/00006454-198704000-00011</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0891-3668 |
| ispartof | The Pediatric infectious disease journal, 1987-04, Vol.6 (4), p.398-403 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Antibodies, Viral - analysis Female Humans Immunity, Maternally-Acquired Infant Influenza A virus - immunology Influenza A virus - isolation & purification Influenza, Human - immunology Pregnancy Prospective Studies |
| title | Effect of passive maternal antibody on influenza illness in children: a prospective study of influenza A in mother-infant pairs |
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