Growth Hormone-releasing factor releases acth from an AtT-20 mouse pituitary tumor cell line but not from normal pituitary cells

Corticotropin-releasing factor (CRF) and both human pancreatic growth hormone-releasing factor (hp-GRF) and rat hypothalamic GRF (rh-GRF) stimulated ACTH release from neoplastic AtT-20 mouse pituitary tumor cells in a dose-dependent fashion, with CRF inducing a 10-fold increase and GRF a maximal inc...

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Veröffentlicht in:	Life sciences (1973) 1987-06, Vol.40 (22), p.2161-2167
Hauptverfasser:	Nakane, Toschichi, Tsai, Jir, Audhya, Tapan, Brown, Cynthia, Kardos, Paula, Hollander, Charles S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - metabolism Animal tumors. Experimental tumors Animals Biological and medical sciences Cell Line Cells, Cultured Corticotropin-Releasing Hormone - pharmacology Cyclic AMP - metabolism Dexamethasone - pharmacology Experimental endocrine tumors Growth Hormone-Releasing Hormone - pharmacology Medical sciences Mice Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Pituitary Neoplasms - metabolism Radioimmunoassay Somatostatin - pharmacology Tumors
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