Alteration in the Ribonucleic Acids in Rat Liver Induced by a Methionine-Free Total Parenteral Nutrition Solution
The effect of infusion of a methionine-free total parenteral nutrition solution for 7 d on ribonucleic acids in liver of rats were investigated. The control solution contained leucine, valine, isoleucine, lysine, phenyialanine, threonine, tryptophan, arginine, histidine, glycine, methionine, glucose...
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| Veröffentlicht in: | The Journal of nutrition 1987-04, Vol.117 (4), p.673-677 |
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| creator | Aoi, Shozo Wen, Long-Thung Kuwahata, Tokuo Tsukada, Kinji |
| description | The effect of infusion of a methionine-free total parenteral nutrition solution for 7 d on ribonucleic acids in liver of rats were investigated. The control solution contained leucine, valine, isoleucine, lysine, phenyialanine, threonine, tryptophan, arginine, histidine, glycine, methionine, glucose and vitamins and minerals. Deprivation of a methionine is known to increase the activity of RNA polymerase I. Infusing the methionine-free solution resulted in the accumulation of RNA molecules larger than 28S in the liver nuclei and resulted in a higher rate of rRNA synthesis than in rats infused with the control solution. A methionine deficiency did not impede either the processing of 45S pre-rRNA or transport of 28S and 18S rRNA into cytoplasm. When rats were infused with the methionine-free solution for 7 d followed by the control solution for 2 d, the level of RNA in the nucleus as well as the rate of RNA polymerase I were similar to the levels in rats receiving the control solution for 9 d. There were no significant changes in the rate of DNA synthesis due to nutritional manipulations. |
| doi_str_mv | 10.1093/jn/117.4.673 |
| format | Article |
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The control solution contained leucine, valine, isoleucine, lysine, phenyialanine, threonine, tryptophan, arginine, histidine, glycine, methionine, glucose and vitamins and minerals. Deprivation of a methionine is known to increase the activity of RNA polymerase I. Infusing the methionine-free solution resulted in the accumulation of RNA molecules larger than 28S in the liver nuclei and resulted in a higher rate of rRNA synthesis than in rats infused with the control solution. A methionine deficiency did not impede either the processing of 45S pre-rRNA or transport of 28S and 18S rRNA into cytoplasm. When rats were infused with the methionine-free solution for 7 d followed by the control solution for 2 d, the level of RNA in the nucleus as well as the rate of RNA polymerase I were similar to the levels in rats receiving the control solution for 9 d. There were no significant changes in the rate of DNA synthesis due to nutritional manipulations.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/117.4.673</identifier><identifier>PMID: 2438390</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>ALIMENTACION PARENTERAL ; ALIMENTATION ENTERALE ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Body Weight ; Cell Nucleolus - enzymology ; Cell Nucleus - metabolism ; Cytoplasm - metabolism ; DNA - biosynthesis ; Electrophoresis, Polyacrylamide Gel ; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition ; FOIE ; HIGADO ; Intensive care medicine ; LIVER ; Liver - metabolism ; Liver - ultrastructure ; Male ; Medical sciences ; METHIONINE ; Methionine - blood ; Methionine - deficiency ; METIONINA ; Organ Size ; PARENTERAL FEEDING ; RAT ; RATA ; RATS ; ribonucleic acids ; RNA - biosynthesis ; RNA Polymerase I - analysis ; total parenteral nutrition</subject><ispartof>The Journal of nutrition, 1987-04, Vol.117 (4), p.673-677</ispartof><rights>1987 American Society for Nutrition.</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-99887d15fd04481dd640472d6f834241e39a1afc22f7d0f55db075d815623fae3</citedby><cites>FETCH-LOGICAL-c419t-99887d15fd04481dd640472d6f834241e39a1afc22f7d0f55db075d815623fae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7381740$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2438390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aoi, Shozo</creatorcontrib><creatorcontrib>Wen, Long-Thung</creatorcontrib><creatorcontrib>Kuwahata, Tokuo</creatorcontrib><creatorcontrib>Tsukada, Kinji</creatorcontrib><title>Alteration in the Ribonucleic Acids in Rat Liver Induced by a Methionine-Free Total Parenteral Nutrition Solution</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The effect of infusion of a methionine-free total parenteral nutrition solution for 7 d on ribonucleic acids in liver of rats were investigated. The control solution contained leucine, valine, isoleucine, lysine, phenyialanine, threonine, tryptophan, arginine, histidine, glycine, methionine, glucose and vitamins and minerals. Deprivation of a methionine is known to increase the activity of RNA polymerase I. Infusing the methionine-free solution resulted in the accumulation of RNA molecules larger than 28S in the liver nuclei and resulted in a higher rate of rRNA synthesis than in rats infused with the control solution. A methionine deficiency did not impede either the processing of 45S pre-rRNA or transport of 28S and 18S rRNA into cytoplasm. When rats were infused with the methionine-free solution for 7 d followed by the control solution for 2 d, the level of RNA in the nucleus as well as the rate of RNA polymerase I were similar to the levels in rats receiving the control solution for 9 d. There were no significant changes in the rate of DNA synthesis due to nutritional manipulations.</description><subject>ALIMENTACION PARENTERAL</subject><subject>ALIMENTATION ENTERALE</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Cell Nucleolus - enzymology</subject><subject>Cell Nucleus - metabolism</subject><subject>Cytoplasm - metabolism</subject><subject>DNA - biosynthesis</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</subject><subject>FOIE</subject><subject>HIGADO</subject><subject>Intensive care medicine</subject><subject>LIVER</subject><subject>Liver - metabolism</subject><subject>Liver - ultrastructure</subject><subject>Male</subject><subject>Medical sciences</subject><subject>METHIONINE</subject><subject>Methionine - blood</subject><subject>Methionine - deficiency</subject><subject>METIONINA</subject><subject>Organ Size</subject><subject>PARENTERAL FEEDING</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>ribonucleic acids</subject><subject>RNA - biosynthesis</subject><subject>RNA Polymerase I - analysis</subject><subject>total parenteral nutrition</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1rHCEYhyW0pNs0t54KBQ8lp85GR2fU4xKaNrD9IB9ncfW1cZl1EnUC-e_jdJecelJ4Hn_Ig9BHSpaUKHa-jeeUiiVf9oIdoQXtOG16SsgbtCCkbRtG-_4dep_zlhBCuZLH6LjlTDJFFuhxNRRIpoQx4hBxuQd8HTZjnOwAweKVDS7P4NoUvA5PkPBVdJMFhzfP2OCfUO7r0xChuUwA-HYsZsB_TII4zw7411RS-Ld-Mw7TfPmA3nozZDg9nCfo7vLb7cWPZv37-9XFat1YTlVplJJSONp5RziX1LmeEy5a13vJeMspMGWo8bZtvXDEd53bENE5Sbu-Zd4AO0Fn-92HND5OkIvehWxhGEyEccpaiK4jUvEqft2LNo05J_D6IYWdSc-aEj0X1tuoa2HNdS1c9c-H3WmzA_cqH5JW_uXATbZm8MlEG_KrJpikgs_ap73mzajN31SVuxspmGJKVdjvIdRATwGSzjZArNlDAlu0G8P_P_cCmuGdvw</recordid><startdate>19870401</startdate><enddate>19870401</enddate><creator>Aoi, Shozo</creator><creator>Wen, Long-Thung</creator><creator>Kuwahata, Tokuo</creator><creator>Tsukada, Kinji</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870401</creationdate><title>Alteration in the Ribonucleic Acids in Rat Liver Induced by a Methionine-Free Total Parenteral Nutrition Solution</title><author>Aoi, Shozo ; Wen, Long-Thung ; Kuwahata, Tokuo ; Tsukada, Kinji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-99887d15fd04481dd640472d6f834241e39a1afc22f7d0f55db075d815623fae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>ALIMENTACION PARENTERAL</topic><topic>ALIMENTATION ENTERALE</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Cell Nucleolus - enzymology</topic><topic>Cell Nucleus - metabolism</topic><topic>Cytoplasm - metabolism</topic><topic>DNA - biosynthesis</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</topic><topic>FOIE</topic><topic>HIGADO</topic><topic>Intensive care medicine</topic><topic>LIVER</topic><topic>Liver - metabolism</topic><topic>Liver - ultrastructure</topic><topic>Male</topic><topic>Medical sciences</topic><topic>METHIONINE</topic><topic>Methionine - blood</topic><topic>Methionine - deficiency</topic><topic>METIONINA</topic><topic>Organ Size</topic><topic>PARENTERAL FEEDING</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>ribonucleic acids</topic><topic>RNA - biosynthesis</topic><topic>RNA Polymerase I - analysis</topic><topic>total parenteral nutrition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aoi, Shozo</creatorcontrib><creatorcontrib>Wen, Long-Thung</creatorcontrib><creatorcontrib>Kuwahata, Tokuo</creatorcontrib><creatorcontrib>Tsukada, Kinji</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoi, Shozo</au><au>Wen, Long-Thung</au><au>Kuwahata, Tokuo</au><au>Tsukada, Kinji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration in the Ribonucleic Acids in Rat Liver Induced by a Methionine-Free Total Parenteral Nutrition Solution</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1987-04-01</date><risdate>1987</risdate><volume>117</volume><issue>4</issue><spage>673</spage><epage>677</epage><pages>673-677</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>The effect of infusion of a methionine-free total parenteral nutrition solution for 7 d on ribonucleic acids in liver of rats were investigated. The control solution contained leucine, valine, isoleucine, lysine, phenyialanine, threonine, tryptophan, arginine, histidine, glycine, methionine, glucose and vitamins and minerals. Deprivation of a methionine is known to increase the activity of RNA polymerase I. Infusing the methionine-free solution resulted in the accumulation of RNA molecules larger than 28S in the liver nuclei and resulted in a higher rate of rRNA synthesis than in rats infused with the control solution. A methionine deficiency did not impede either the processing of 45S pre-rRNA or transport of 28S and 18S rRNA into cytoplasm. When rats were infused with the methionine-free solution for 7 d followed by the control solution for 2 d, the level of RNA in the nucleus as well as the rate of RNA polymerase I were similar to the levels in rats receiving the control solution for 9 d. There were no significant changes in the rate of DNA synthesis due to nutritional manipulations.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>2438390</pmid><doi>10.1093/jn/117.4.673</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ALIMENTACION PARENTERAL ALIMENTATION ENTERALE Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Body Weight Cell Nucleolus - enzymology Cell Nucleus - metabolism Cytoplasm - metabolism DNA - biosynthesis Electrophoresis, Polyacrylamide Gel Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition FOIE HIGADO Intensive care medicine LIVER Liver - metabolism Liver - ultrastructure Male Medical sciences METHIONINE Methionine - blood Methionine - deficiency METIONINA Organ Size PARENTERAL FEEDING RAT RATA RATS ribonucleic acids RNA - biosynthesis RNA Polymerase I - analysis total parenteral nutrition |
| title | Alteration in the Ribonucleic Acids in Rat Liver Induced by a Methionine-Free Total Parenteral Nutrition Solution |
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