A Novel Homeobox Cluster Expressed in Repeated Structures of the Midgut
A gene cluster (LOX3-C) containing three duplicated homeobox sequences (Lox3A, Lox3B, and Lox3C) was characterized in the leech Hirudo medicinalis . The leech homeoboxes have a limited homology to those of Antennapedia-class genes, but do not have homologs among currently characterized insect genes....
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| Veröffentlicht in: | Developmental biology 1995-10, Vol.171 (2), p.439-447 |
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| creator | Wysocka-Diller, Joanna Aisemberg, Gabriel O. Macagno, Eduardo R. |
| description | A gene cluster (LOX3-C) containing three duplicated homeobox sequences (Lox3A, Lox3B, and Lox3C) was characterized in the leech Hirudo medicinalis . The leech homeoboxes have a limited homology to those of Antennapedia-class genes, but do not have homologs among currently characterized insect genes. The Lox3 genes belong to a new family, named Xlox, that also includes genes from mouse, rat, frog, and a distantly related leech, Helobdella triserialis. All members of the Xlox family are expressed in specific regions of the embryonic gut, where they seem to affect morphogenesis and cell differentiation. The three homeoboxes of LOX3-C described here are contained within nearly identical direct tandem repeats. The LOX3-C region produces at least two transcripts, one present in both embryos and adults and the other only in early embryos. Early Lox3 expression is restricted to specific regions of the midgut primordium, in 12 segmentally repeated, transverse stripes of fusiform cells found at the positions where the midgut will constrict to form the 11 diverticula of the crop. A role in the development of segmentally iterated structures in an initially homogeneous midgut is proposed for LOX3-C. |
| doi_str_mv | 10.1006/dbio.1995.1294 |
| format | Article |
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The leech homeoboxes have a limited homology to those of Antennapedia-class genes, but do not have homologs among currently characterized insect genes. The Lox3 genes belong to a new family, named Xlox, that also includes genes from mouse, rat, frog, and a distantly related leech, Helobdella triserialis. All members of the Xlox family are expressed in specific regions of the embryonic gut, where they seem to affect morphogenesis and cell differentiation. The three homeoboxes of LOX3-C described here are contained within nearly identical direct tandem repeats. The LOX3-C region produces at least two transcripts, one present in both embryos and adults and the other only in early embryos. Early Lox3 expression is restricted to specific regions of the midgut primordium, in 12 segmentally repeated, transverse stripes of fusiform cells found at the positions where the midgut will constrict to form the 11 diverticula of the crop. 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The leech homeoboxes have a limited homology to those of Antennapedia-class genes, but do not have homologs among currently characterized insect genes. The Lox3 genes belong to a new family, named Xlox, that also includes genes from mouse, rat, frog, and a distantly related leech, Helobdella triserialis. All members of the Xlox family are expressed in specific regions of the embryonic gut, where they seem to affect morphogenesis and cell differentiation. The three homeoboxes of LOX3-C described here are contained within nearly identical direct tandem repeats. The LOX3-C region produces at least two transcripts, one present in both embryos and adults and the other only in early embryos. Early Lox3 expression is restricted to specific regions of the midgut primordium, in 12 segmentally repeated, transverse stripes of fusiform cells found at the positions where the midgut will constrict to form the 11 diverticula of the crop. A role in the development of segmentally iterated structures in an initially homogeneous midgut is proposed for LOX3-C.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>DNA, Complementary - chemistry</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Homeobox</subject><subject>Helobdella triserialis</subject><subject>Hirudo medicinalis</subject><subject>Intestines - embryology</subject><subject>Leeches</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFLJDEQRoO46Kzu1ZuQk7ceU92TyuQog44L6sKuwt5COl2tkZ7JmKRF_73dzOBNPFXB99WDeoydgJiCEHje1D5MQWs5hVLP9tgEhJaFxNn_fTYRAsoCUOAh-5nSsxCims-rA3agpERd4oQtL_hdeKWOX4cVhTq88UXXp0yRX75tIqVEDfdr_pc2ZPOw_8uxd7kfEh5anp-I3_rmsc_H7Edru0S_dvOIPVxd3i-ui5s_y9-Li5vCzUDkAqGyAoGcqrR2liqNVpYapLJSUA2ytQ5qwNY5O8MSGlKKAJtKy1JpgdURO9tyNzG89JSyWfnkqOvsmkKfjBo-E6jUt0WQiDiHkTjdFl0MKUVqzSb6lY3vBoQZFZtRsRkVm1HxcHC6I_f1iprP-s7pkM-3OQ0eXj1Fk5yntaPGR3LZNMF_hf4ANwOJfg</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>Wysocka-Diller, Joanna</creator><creator>Aisemberg, Gabriel O.</creator><creator>Macagno, Eduardo R.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19951001</creationdate><title>A Novel Homeobox Cluster Expressed in Repeated Structures of the Midgut</title><author>Wysocka-Diller, Joanna ; Aisemberg, Gabriel O. ; Macagno, Eduardo R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-613a061ec7399cae396a529157a50eb15fac1b16fcca4621de77e16d395279063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>DNA, Complementary - chemistry</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Homeobox</topic><topic>Helobdella triserialis</topic><topic>Hirudo medicinalis</topic><topic>Intestines - embryology</topic><topic>Leeches</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wysocka-Diller, Joanna</creatorcontrib><creatorcontrib>Aisemberg, Gabriel O.</creatorcontrib><creatorcontrib>Macagno, Eduardo R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wysocka-Diller, Joanna</au><au>Aisemberg, Gabriel O.</au><au>Macagno, Eduardo R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Novel Homeobox Cluster Expressed in Repeated Structures of the Midgut</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>171</volume><issue>2</issue><spage>439</spage><epage>447</epage><pages>439-447</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><abstract>A gene cluster (LOX3-C) containing three duplicated homeobox sequences (Lox3A, Lox3B, and Lox3C) was characterized in the leech Hirudo medicinalis . 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| ispartof | Developmental biology, 1995-10, Vol.171 (2), p.439-447 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier) |
| subjects | Amino Acid Sequence Animals Base Sequence DNA, Complementary - chemistry Gene Expression Regulation, Developmental Genes, Homeobox Helobdella triserialis Hirudo medicinalis Intestines - embryology Leeches Molecular Sequence Data Multigene Family |
| title | A Novel Homeobox Cluster Expressed in Repeated Structures of the Midgut |
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