Inhibition of Monoamine Oxidase-B by 5H-Indeno[1,2-c]pyridazines: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSARs

A large series (66 compounds) of indeno[1,2-c]pyridazin-5-ones (IPs) were synthesized and tested on their monoamine oxidase-A (MAO-A) and MAO-B inhibitory activity. All of the tested compounds acted preferentially on MAO-B displaying weak (nonmeasurable IC50 values) to high (submicromolar IC50 value...

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Veröffentlicht in:	Journal of medicinal chemistry 1995-09, Vol.38 (19), p.3874-3883
Hauptverfasser:	Kneubuehler, Silvia, Thull, Ulrike, Altomare, Cosimo, Carta, Vincenco, Gaillard, Patrick, Carrupt, Pierre-Alain, Carotti, Angelo, Testa, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Computer Graphics Magnetic Resonance Spectroscopy Medical sciences Models, Molecular Molecular Conformation Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - chemistry Monoamine Oxidase Inhibitors - pharmacology Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyridazines - chemical synthesis Pyridazines - chemistry Pyridazines - pharmacology Spectrum Analysis Structure-Activity Relationship
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