Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione and related quinoxalinediones: characterization of .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity

Four related series of substituted quinoxalinediones containing angular fused-piperidine rings have been synthesized as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists with potential as neuroprotective agents, primarily for acute therapy immediately following a s...

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Veröffentlicht in:	Journal of medicinal chemistry 1995-09, Vol.38 (19), p.3720-3740
Hauptverfasser:	Bigge, Christopher F, Malone, Thomas C, Boxer, Peter A, Nelson, Carrie B, Ortwine, Daniel F, Schelkun, Robert, Retz, Daniel M, Lescosky, Leonard J, Borosky, Susan A
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - metabolism Animals Anticonvulsants - chemical synthesis Anticonvulsants - chemistry Anticonvulsants - metabolism Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Binding Sites Binding, Competitive Biological and medical sciences Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - physiology Computer Graphics Excitatory Amino Acid Antagonists - chemical synthesis Excitatory Amino Acid Antagonists - chemistry Excitatory Amino Acid Antagonists - metabolism Excitatory Amino Acid Antagonists - pharmacology Glycine - metabolism Kainic Acid - metabolism Medical sciences Mice Models, Molecular Molecular Structure Neurons - cytology Neurons - drug effects Neuropharmacology Pharmacology. Drug treatments Quinoxalines - chemical synthesis Quinoxalines - chemistry Quinoxalines - metabolism Quinoxalines - pharmacology Rats Rats, Wistar Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Regression Analysis Structure-Activity Relationship
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