The Covalent Structure of Factor XIIIa Crosslinked Fibrinogen Fibrils

When factor XIIIa-mediated crosslinking of fibrin or fibrinogen occurs, reciprocal intermolecular isopeptide bonds form first between paired carboxy terminal γ chain donor-acceptor sites in outer molecular D domains, resulting in γ chain dimers. Their location in the fibrin polymer is not certain, b...

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Veröffentlicht in:	Journal of structural biology 1995-07, Vol.115 (1), p.88-101
Hauptverfasser:	Mosesson, M.W., Siebenlist, K.R., Hainfeld, J.F., Wall, J.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, Gel Cross-Linking Reagents Electrophoresis, Polyacrylamide Gel Fibrin - chemistry Fibrin - metabolism Fibrin - ultrastructure Fibrinogen - chemistry Fibrinogen - metabolism Fibrinogen - ultrastructure Glutamic Acid - metabolism Hirudins - pharmacology Humans Lysine - metabolism Microscopy, Electron Microscopy, Electron, Scanning Transmission Models, Molecular Molecular Weight Transglutaminases - metabolism
Online-Zugang:	Volltext
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