Chromosomally Abnormal Clones and Nonrandom Telomeric Translocations in Cardiac Myxomas
Cardiac myxomas from eight patients were examined cytogenetically in short-term cultures. Cultures could not be established in two of the eight cases. Chromosomally abnormal clones occurred in two of the myxomas; their karyotypes were 45,X,-Y,+7,-18 and 45,X,-Y. In three other myxomas, we found a ra...
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| Veröffentlicht in: | Mayo Clinic proceedings 1987-07, Vol.62 (7), p.558-567 |
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| creator | DEWALD, GORDON W. DAHL, RICHARD J. SPURBECK, JACK L. CARNEY, J. AIDAN GORDON, HYMIE |
| description | Cardiac myxomas from eight patients were examined cytogenetically in short-term cultures. Cultures could not be established in two of the eight cases. Chromosomally abnormal clones occurred in two of the myxomas; their karyotypes were 45,X,-Y,+7,-18 and 45,X,-Y. In three other myxomas, we found a rare kind of telomere-to-telomere translocation between chromosomes. The telomeres predominantly involved in these three tumors were the 2qter (the end of the long arm of chromosome 2), the 12pter (the end of the short arm of chromosome 12), and Yqter (the end of the long arm of the Y chromosome), respectively. In one other myxoma, 20% of the cells were tetraploid. These findings support the concept that myxomas are neoplastic; those with an abnormal clone may even have malignant potential. The unusual telomere-to-telomere translocations were not observed in a clonal pattern. They may represent a specific type of chromosomal instability associated with a defect in repair or replication of telomeric DNA. |
| doi_str_mv | 10.1016/S0025-6196(12)62293-9 |
| format | Article |
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The unusual telomere-to-telomere translocations were not observed in a clonal pattern. They may represent a specific type of chromosomal instability associated with a defect in repair or replication of telomeric DNA.</description><identifier>ISSN: 0025-6196</identifier><identifier>EISSN: 1942-5546</identifier><identifier>DOI: 10.1016/S0025-6196(12)62293-9</identifier><identifier>PMID: 3586714</identifier><identifier>CODEN: MACPAJ</identifier><language>eng</language><publisher>Rochester, MN: Elsevier Inc</publisher><subject>Adult ; Aged ; Base Sequence ; Biological and medical sciences ; Cardiology. 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AIDAN</creatorcontrib><creatorcontrib>GORDON, HYMIE</creatorcontrib><title>Chromosomally Abnormal Clones and Nonrandom Telomeric Translocations in Cardiac Myxomas</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>Cardiac myxomas from eight patients were examined cytogenetically in short-term cultures. Cultures could not be established in two of the eight cases. Chromosomally abnormal clones occurred in two of the myxomas; their karyotypes were 45,X,-Y,+7,-18 and 45,X,-Y. In three other myxomas, we found a rare kind of telomere-to-telomere translocation between chromosomes. The telomeres predominantly involved in these three tumors were the 2qter (the end of the long arm of chromosome 2), the 12pter (the end of the short arm of chromosome 12), and Yqter (the end of the long arm of the Y chromosome), respectively. In one other myxoma, 20% of the cells were tetraploid. These findings support the concept that myxomas are neoplastic; those with an abnormal clone may even have malignant potential. The unusual telomere-to-telomere translocations were not observed in a clonal pattern. They may represent a specific type of chromosomal instability associated with a defect in repair or replication of telomeric DNA.</description><subject>Adult</subject><subject>Aged</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cells, Cultured</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Disorders</subject><subject>Clone Cells</subject><subject>DNA</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Neoplasms - genetics</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metaphase</subject><subject>Middle Aged</subject><subject>Myxoma - genetics</subject><subject>Translocation, Genetic</subject><subject>Tumors of the heart</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOGzEUQC1UBOHxCUheoKosBvwee1WhEbSVeCwIYml5bI8w8oypnVTk73FIlG1X1_I993UAOMPoEiMsrp4QIrwRWIkfmFwIQhRt1B6YYcVIwzkT38BshxyCo1LeEEKtUuwAHFAuRYvZDLx0rzmNqaTRxLiC1_2Ucn3CLqbJF2gmBx_SlGtMI5z7mEafg4Xz-lNismYR0lRgmGBnsgvGwvvVR-1VTsD-YGLxp9t4DJ5vb-bd7-bu8def7vqusVSqRaMEV5JKMQzU9YgqOWDVY-Za3jrietEPfW-ws947Sh0mSionGMam5fUWJukx-L7p-57T36UvCz2GYn2MZvJpWXTbcsak4BXkG9DmVEr2g37PYTR5pTHSa6H6S6he29KY6C-hWtW6s-2AZT96t6vaGqz5823eFGviUMXYUHaYpGRNVeznBvNVxr_gsy42-Ml6F7K3C-1S-M8inxqBkns</recordid><startdate>19870701</startdate><enddate>19870701</enddate><creator>DEWALD, GORDON W.</creator><creator>DAHL, RICHARD J.</creator><creator>SPURBECK, JACK L.</creator><creator>CARNEY, J. AIDAN</creator><creator>GORDON, HYMIE</creator><general>Elsevier Inc</general><general>Mayo Medical Ventures</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870701</creationdate><title>Chromosomally Abnormal Clones and Nonrandom Telomeric Translocations in Cardiac Myxomas</title><author>DEWALD, GORDON W. ; DAHL, RICHARD J. ; SPURBECK, JACK L. ; CARNEY, J. AIDAN ; GORDON, HYMIE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-96598386ff3db0398f19b14d757d2db6bfbba1dceed33d12989d6411a75007483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cells, Cultured</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Disorders</topic><topic>Clone Cells</topic><topic>DNA</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Neoplasms - genetics</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metaphase</topic><topic>Middle Aged</topic><topic>Myxoma - genetics</topic><topic>Translocation, Genetic</topic><topic>Tumors of the heart</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEWALD, GORDON W.</creatorcontrib><creatorcontrib>DAHL, RICHARD J.</creatorcontrib><creatorcontrib>SPURBECK, JACK L.</creatorcontrib><creatorcontrib>CARNEY, J. 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AIDAN</au><au>GORDON, HYMIE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosomally Abnormal Clones and Nonrandom Telomeric Translocations in Cardiac Myxomas</atitle><jtitle>Mayo Clinic proceedings</jtitle><addtitle>Mayo Clin Proc</addtitle><date>1987-07-01</date><risdate>1987</risdate><volume>62</volume><issue>7</issue><spage>558</spage><epage>567</epage><pages>558-567</pages><issn>0025-6196</issn><eissn>1942-5546</eissn><coden>MACPAJ</coden><abstract>Cardiac myxomas from eight patients were examined cytogenetically in short-term cultures. Cultures could not be established in two of the eight cases. Chromosomally abnormal clones occurred in two of the myxomas; their karyotypes were 45,X,-Y,+7,-18 and 45,X,-Y. In three other myxomas, we found a rare kind of telomere-to-telomere translocation between chromosomes. The telomeres predominantly involved in these three tumors were the 2qter (the end of the long arm of chromosome 2), the 12pter (the end of the short arm of chromosome 12), and Yqter (the end of the long arm of the Y chromosome), respectively. In one other myxoma, 20% of the cells were tetraploid. These findings support the concept that myxomas are neoplastic; those with an abnormal clone may even have malignant potential. The unusual telomere-to-telomere translocations were not observed in a clonal pattern. They may represent a specific type of chromosomal instability associated with a defect in repair or replication of telomeric DNA.</abstract><cop>Rochester, MN</cop><pub>Elsevier Inc</pub><pmid>3586714</pmid><doi>10.1016/S0025-6196(12)62293-9</doi><tpages>10</tpages></addata></record> |
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| ispartof | Mayo Clinic proceedings, 1987-07, Vol.62 (7), p.558-567 |
| issn | 0025-6196 1942-5546 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Base Sequence Biological and medical sciences Cardiology. Vascular system Cells, Cultured Chromosome Aberrations Chromosome Disorders Clone Cells DNA Female Heart Heart Neoplasms - genetics Humans Karyotyping Male Medical sciences Metaphase Middle Aged Myxoma - genetics Translocation, Genetic Tumors of the heart |
| title | Chromosomally Abnormal Clones and Nonrandom Telomeric Translocations in Cardiac Myxomas |
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