The cytostatic activity of 5-(1-azidovinyl)-2′-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light ( λ = 254 nm) exposure

5-(1-Azidovinyl)-2′-deoxyuridine (AzVDU) and a series of 5-[1-azido-2-halogenoethyl]-derivatives of β- d-arabinofuranosyluracil (AU) proved markedly inhibitory to the replication of herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV), but not thymidine kinase (TK)-deficient HSV-1 an...

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Veröffentlicht in:	FEBS letters 1995-10, Vol.373 (1), p.41-44
Hauptverfasser:	Balzarini, J., Andrei, G., Kumar, R., Knaus, E.E., Wiebe, L.I., De Clercq, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antiviral Agents - pharmacology Azides - pharmacology Azidovinyldeoxyuridine Cell Division - drug effects Deoxyuridine - analogs & derivatives Deoxyuridine - pharmacology Gene therapy Herpes simplex virus Herpesvirus 3, Human - drug effects Herpesvirus 3, Human - physiology Mammary Neoplasms, Experimental Mice Mice, Inbred C3H Molecular Structure Recombinant Proteins - biosynthesis Simplexvirus - drug effects Simplexvirus - genetics Simplexvirus - physiology Structure-Activity Relationship Thymidine kinase Thymidine Kinase - biosynthesis Thymidylate synthase Transfection Tumor Cells, Cultured varicella-zoster virus Virus Replication - drug effects
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