Effect of zinc and/or pyridoxine deficiency upon oestrogen retention and oestrogen receptor distribution in the rat uterus
A deficiency of vitamin B 6 has been reported to enhance oestrogen responsiveness of the uterus in rats whereas zinc deficiency provokes a syndrome suggestive of a diminution in oestrogen sensitivity. In this study [ 3H]oestrogen uptake by the uterus was increased in rats deficient in either nutrien...
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| Veröffentlicht in: | Journal of steroid biochemistry 1987-03, Vol.26 (3), p.303-308 |
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| container_title | Journal of steroid biochemistry |
| container_volume | 26 |
| creator | Bunce, G.E. Vessal, Mahmood |
| description | A deficiency of vitamin B
6 has been reported to enhance oestrogen responsiveness of the uterus in rats whereas zinc deficiency provokes a syndrome suggestive of a diminution in oestrogen sensitivity. In this study [
3H]oestrogen uptake by the uterus was increased in rats deficient in either nutrient and the differences were additive in the dually deficient animals. The total number of oestrogen receptors per g tissue was unaffected by either nutrient but the proportion of the receptors recovered from the nuclear fraction increased from about 6 to 74% when both nutrients were withheld. The results are consistent with the hypothesis that both zinc and pyridoxal phosphate play important metabolic roles in end-organ responsiveness to oestrogen. |
| doi_str_mv | 10.1016/0022-4731(87)90093-8 |
| format | Article |
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6 has been reported to enhance oestrogen responsiveness of the uterus in rats whereas zinc deficiency provokes a syndrome suggestive of a diminution in oestrogen sensitivity. In this study [
3H]oestrogen uptake by the uterus was increased in rats deficient in either nutrient and the differences were additive in the dually deficient animals. The total number of oestrogen receptors per g tissue was unaffected by either nutrient but the proportion of the receptors recovered from the nuclear fraction increased from about 6 to 74% when both nutrients were withheld. The results are consistent with the hypothesis that both zinc and pyridoxal phosphate play important metabolic roles in end-organ responsiveness to oestrogen.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Eating</subject><subject>Estradiol - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Pyridoxal Phosphate - blood</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Steroid hormones. Cholecalciferol derivatives</subject><subject>Uterus - metabolism</subject><subject>Vertebrates: endocrinology</subject><subject>Vitamin B 6 Deficiency - metabolism</subject><subject>Zinc - blood</subject><subject>Zinc - deficiency</subject><issn>0022-4731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctqHDEQ1CHBcTb-gwR0MCE-TKzXjDQXQzB-gcEX-yw0Uk-isCtNJE3w-uujfbDgS3wSVFeVuqsQ-kzJd0pod04IY42QnH5T8qwnpOeNeoeOD_AH9DHn34TQXgl2hI54q7pOyGP0cjWOYAuOI37xwWIT3HlMeFon7-KzD4AdjN56CHaN5ykGHCGXFH9CwAkKhOIrVlWvcAtTqS7OV8gP85bjAy6_ACdT8FwgzfkTej-aZYaT_btAT9dXj5e3zf3Dzd3lj_vGCipLo5S1XQvMkW5k0g0955ITPpi-BVpvE8wBHzgTfGh72Yk6Z846S1sF7TC0fIG-7nynFP_MdUu98tnCcmkCxDlrKVvBFKVvEqmokdHqv0BiR7Qp5pxg1FPyK5PWmhK96UNvgteb4LWSetuHVlX2Ze8_DytwB9G-jDo_3c9NtmY5JhOszweaYvVzKSrtYkeDGtpfD0nnbT_gfE2-aBf9__f4Bxr9qjo</recordid><startdate>19870301</startdate><enddate>19870301</enddate><creator>Bunce, G.E.</creator><creator>Vessal, Mahmood</creator><general>Elsevier B.V</general><general>Pergamon</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19870301</creationdate><title>Effect of zinc and/or pyridoxine deficiency upon oestrogen retention and oestrogen receptor distribution in the rat uterus</title><author>Bunce, G.E. ; Vessal, Mahmood</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-88cc65e2d06f27db9337303ba95e147342de3b3243b597649332dcdc158e5bb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Eating</topic><topic>Estradiol - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Pyridoxal Phosphate - blood</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Steroid hormones. Cholecalciferol derivatives</topic><topic>Uterus - metabolism</topic><topic>Vertebrates: endocrinology</topic><topic>Vitamin B 6 Deficiency - metabolism</topic><topic>Zinc - blood</topic><topic>Zinc - deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bunce, G.E.</creatorcontrib><creatorcontrib>Vessal, Mahmood</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of steroid biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bunce, G.E.</au><au>Vessal, Mahmood</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of zinc and/or pyridoxine deficiency upon oestrogen retention and oestrogen receptor distribution in the rat uterus</atitle><jtitle>Journal of steroid biochemistry</jtitle><addtitle>J Steroid Biochem</addtitle><date>1987-03-01</date><risdate>1987</risdate><volume>26</volume><issue>3</issue><spage>303</spage><epage>308</epage><pages>303-308</pages><issn>0022-4731</issn><coden>JSTBBK</coden><abstract>A deficiency of vitamin B
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3H]oestrogen uptake by the uterus was increased in rats deficient in either nutrient and the differences were additive in the dually deficient animals. The total number of oestrogen receptors per g tissue was unaffected by either nutrient but the proportion of the receptors recovered from the nuclear fraction increased from about 6 to 74% when both nutrients were withheld. The results are consistent with the hypothesis that both zinc and pyridoxal phosphate play important metabolic roles in end-organ responsiveness to oestrogen.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3586647</pmid><doi>10.1016/0022-4731(87)90093-8</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of steroid biochemistry, 1987-03, Vol.26 (3), p.303-308 |
| issn | 0022-4731 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77542811 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Body Weight Eating Estradiol - metabolism Female Fundamental and applied biological sciences. Psychology Pyridoxal Phosphate - blood Rats Rats, Inbred Strains Receptors, Estrogen - metabolism Steroid hormones. Cholecalciferol derivatives Uterus - metabolism Vertebrates: endocrinology Vitamin B 6 Deficiency - metabolism Zinc - blood Zinc - deficiency |
| title | Effect of zinc and/or pyridoxine deficiency upon oestrogen retention and oestrogen receptor distribution in the rat uterus |
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