Synthesis and oral antifungal activity of novel azolylpropanolones and related compounds

To find orally active antifungal agents, novel imidazolyl- and 1,2,4-triazolylpropanolones I and related compounds II-IV were synthesized. Compounds I were derived from ketones V (method A), alpha-diketone IX (method B), alpha-hydroxy ketones X (method C), alpha-chloro ketone XII (method D), and eno...

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Veröffentlicht in:	Journal of medicinal chemistry 1987-06, Vol.30 (6), p.1054-1068
Hauptverfasser:	Ogata, Masaru, Matsumoto, Hiroshi, Takahashi, Kimio, Shimizu, Sumio, Kida, Shiro, Murabayashi, Akira, Shiro, Motoo, Tawara, Katsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Propanol - chemical synthesis 1-Propanol - pharmacology Administration, Oral Animals Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Azoles - chemical synthesis Azoles - pharmacology Candidiasis - drug therapy Chemistry Condensed matter: structure, mechanical and thermal properties Exact sciences and technology Female Guinea Pigs Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Mice Mice, Inbred ICR Molecular Conformation Organic chemistry Organic compounds Physics Preparations and properties Propanols Structure of solids and liquids crystallography Structure of specific crystalline solids Structure-Activity Relationship
Online-Zugang:	Volltext
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