Proconvulsant effects of theophylline on hippocampal afterdischarges
We tested the effects of the adenosine antagonist, theophylline, on electrically induced afterdischarges in the hippocampus of rats. Theophylline did not significantly alter the threshold for afterdischarge initiation or the duration of the initial afterdischarge. However, theophylline greatly prolo...
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| Veröffentlicht in: | Experimental neurology 1987-06, Vol.96 (3), p.732-735 |
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| container_title | Experimental neurology |
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| creator | Dragunow, M. Goddard, G.V. Laverty, R. |
| description | We tested the effects of the adenosine antagonist, theophylline, on electrically induced afterdischarges in the hippocampus of rats. Theophylline did not significantly alter the threshold for afterdischarge initiation or the duration of the initial afterdischarge. However, theophylline greatly prolonged the duration of secondary afterdischarges, and permitted generalization to motor seizures. Because theophylline antagonizes adenosine, and the hippocampus is a region rich in adenosine binding sites, we interpret these results to mean that endogenous adenosine has little action on focal seizure initiation, but a strong action to suppress secondary seizures and to inhibit seizure generalization. |
| doi_str_mv | 10.1016/0014-4886(87)90234-2 |
| format | Article |
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Theophylline did not significantly alter the threshold for afterdischarge initiation or the duration of the initial afterdischarge. However, theophylline greatly prolonged the duration of secondary afterdischarges, and permitted generalization to motor seizures. Because theophylline antagonizes adenosine, and the hippocampus is a region rich in adenosine binding sites, we interpret these results to mean that endogenous adenosine has little action on focal seizure initiation, but a strong action to suppress secondary seizures and to inhibit seizure generalization.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/0014-4886(87)90234-2</identifier><identifier>PMID: 3582555</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Convulsants ; Hippocampus - drug effects ; Male ; Medical sciences ; Membrane Potentials - drug effects ; Nervous system involvement in other diseases. 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Theophylline did not significantly alter the threshold for afterdischarge initiation or the duration of the initial afterdischarge. However, theophylline greatly prolonged the duration of secondary afterdischarges, and permitted generalization to motor seizures. Because theophylline antagonizes adenosine, and the hippocampus is a region rich in adenosine binding sites, we interpret these results to mean that endogenous adenosine has little action on focal seizure initiation, but a strong action to suppress secondary seizures and to inhibit seizure generalization.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Convulsants</subject><subject>Hippocampus - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Potentials - drug effects</subject><subject>Nervous system involvement in other diseases. 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| ispartof | Experimental neurology, 1987-06, Vol.96 (3), p.732-735 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Convulsants Hippocampus - drug effects Male Medical sciences Membrane Potentials - drug effects Nervous system involvement in other diseases. Miscellaneous Neurology Rats Rats, Inbred Strains Theophylline - pharmacology |
| title | Proconvulsant effects of theophylline on hippocampal afterdischarges |
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