Induction of a Nerve Growth Factor‐Sensitive Kinase that Phosphorylates the DNA‐Binding Domain of the Orphan Nuclear Receptor NGFI‐B

: Nerve growth factor (NGF) induces the synthesis and the phosphorylation of the orphan nuclear receptor NGFI‐B in PC12 cells. Previous work has shown that phosphorylation, by protein kinase A, of a specific serine in the DNA‐binding domain inhibits its binding to the NGFI‐B response element. Also,...

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Veröffentlicht in:	Journal of neurochemistry 1995-10, Vol.65 (4), p.1780-1788
Hauptverfasser:	Hirata, Yoko, Whalin, Michael, Ginty, David D., Xing, Jun, Greenberg, Michael E., Milbrandt, Jeffrey, Guroff, Gordon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cell receptors Cell structures and functions Cyclic AMP Response Element-Binding Protein - metabolism DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Enzyme Induction Epidermal Growth Factor - pharmacology Fibroblast Growth Factors - pharmacology Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Kinase Molecular and cellular biology Molecular Sequence Data Molecular Weight Nerve growth factor Nerve Growth Factors - pharmacology NGFI‐B Nuclear Receptor Subfamily 4, Group A, Member 1 Oligonucleotide Probes - genetics PC12 Cells Phosphorylation Phosphotransferases - chemistry Phosphotransferases - metabolism Rats Receptors, Cytoplasmic and Nuclear Receptors, Steroid Transcription Factors - chemistry Transcription Factors - metabolism
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