Synthesis, structure, and biological activity of certain 2-deoxy-.beta.-D-ribo-hexopyranosyl nucleosides and nucleotides

2-Deoxy-beta-D-ribo-hexopyranosyl nucleosides with adenine (2), hypoxanthine (17), guanine (23), cytosine (13), and uracil (7) as the aglycon were synthesized by the Lewis-acid catalyzed condensation of an appropriate trimethylsilylated heterocyclic base and 2-deoxy-1,3,4,6-tetrakis-O-(4-nitrobenzoy...

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Veröffentlicht in:	Journal of medicinal chemistry 1987-06, Vol.30 (6), p.1044-1054
Hauptverfasser:	Nord, L. Dee, Dalley, N. Kent, McKernan, Patricia A, Robins, Roland K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - analysis Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Carbohydrates. Nucleosides and nucleotides Chemistry Condensed matter: structure, mechanical and thermal properties Exact sciences and technology Heterocyclic compounds Kinetics Magnetic Resonance Spectroscopy Mice Molecular Conformation Nucleosides - chemical synthesis Nucleosides - pharmacology Nucleosides, nucleotides and oligonucleotides Nucleotides - chemical synthesis Nucleotides - pharmacology Organic chemistry Organic compounds Physics Preparations and properties Protein Kinases - analysis Structure of solids and liquids crystallography Structure of specific crystalline solids X-Ray Diffraction
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