OK-1035, a Selective Inhibitor of DNA-Dependent Protein Kinase

Screening for inhibitors of DNA-dependent protein kinase (DNA-PK) revealed 3-cyano-5-(4-pyridyl)-6-hydrazonomethyl-2-pyridone, designated OK-1035, to be a potent and selective inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 μM, a con...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1995-10, Vol.215 (1), p.41-47
Hauptverfasser:	Take, Y., Kumano, M., Hamano, Y., Fukatsu, H., Teraoka, H., Nishimura, S., Okuyama, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Caseins - metabolism Consensus Sequence DNA-Activated Protein Kinase DNA-Binding Proteins Enzyme Inhibitors - pharmacology HeLa Cells - enzymology Humans Hydrazones - chemistry Hydrazones - pharmacology Kinetics Molecular Sequence Data Molecular Structure Nuclear Proteins Peptides - chemistry Peptides - metabolism Phosphorylation Phosphoserine - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Pyridones - chemistry Pyridones - pharmacology Structure-Activity Relationship Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!