Resistance to Transformation by Insertionally Activated c-erbB Is a Dominant Phenotype in Fibroblasts
Tissue-specific factors influence whether cells are susceptible to transformation by erbB oncogenes. Avian fibroblasts resist transformation by insertionally activated c-erbB (IAc- erbB), whereas erythroblasts are transformed by this mutant of the epidermal growth factor receptor. In studies present...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1995-09, Vol.212 (1), p.277-283 |
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| creator | Carter, T.H. Dominguez, N. Zeng, L. Kung, H.-J. |
| description | Tissue-specific factors influence whether cells are susceptible to transformation by
erbB oncogenes. Avian fibroblasts resist transformation by insertionally activated
c-erbB (IAc-
erbB), whereas erythroblasts are transformed by this mutant of the epidermal growth factor receptor. In studies presented here, NIH/3T3 cells resisted transformation by IAc-
erbB. This finding indicates that the nonpermissiveness of fibroblasts is conserved between avian and murine species. Surprisingly, expression of IAc-
erbB blocked transformation by a
v-erbB allele. The
trans-dominant interference by IAc-
erbB occurred despite expression at levels lower than for v-
erbB. Together with previous reports, the results indicate that IAc-
erbB can exert opposite growth effects in different tissues. The switch from positive to negative growth regulation, which depends on the cellular context, provides novel insight into tissue-specific regulation of receptor tyrosine kinases. Evasion of cell-specific inhibition apparently contributes to the distinct tissue tropisms of various
erbB mutants. |
| doi_str_mv | 10.1006/viro.1995.1484 |
| format | Article |
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erbB oncogenes. Avian fibroblasts resist transformation by insertionally activated
c-erbB (IAc-
erbB), whereas erythroblasts are transformed by this mutant of the epidermal growth factor receptor. In studies presented here, NIH/3T3 cells resisted transformation by IAc-
erbB. This finding indicates that the nonpermissiveness of fibroblasts is conserved between avian and murine species. Surprisingly, expression of IAc-
erbB blocked transformation by a
v-erbB allele. The
trans-dominant interference by IAc-
erbB occurred despite expression at levels lower than for v-
erbB. Together with previous reports, the results indicate that IAc-
erbB can exert opposite growth effects in different tissues. The switch from positive to negative growth regulation, which depends on the cellular context, provides novel insight into tissue-specific regulation of receptor tyrosine kinases. Evasion of cell-specific inhibition apparently contributes to the distinct tissue tropisms of various
erbB mutants.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1006/viro.1995.1484</identifier><identifier>PMID: 7676646</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3T3 Cells ; Alleles ; Animals ; Base Sequence ; Cell Transformation, Neoplastic - genetics ; DNA Primers - chemistry ; Fibroblasts ; Genes, Dominant ; Genes, erbB-2 ; Mice ; Molecular Sequence Data ; Oncogenes ; Phenotype</subject><ispartof>Virology (New York, N.Y.), 1995-09, Vol.212 (1), p.277-283</ispartof><rights>1995 Academic Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-f65e91f6465f03cb02d771995c9f2bdc9974b1943130c7e76de3cd96c2114f463</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0042682285714845$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7676646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carter, T.H.</creatorcontrib><creatorcontrib>Dominguez, N.</creatorcontrib><creatorcontrib>Zeng, L.</creatorcontrib><creatorcontrib>Kung, H.-J.</creatorcontrib><title>Resistance to Transformation by Insertionally Activated c-erbB Is a Dominant Phenotype in Fibroblasts</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>Tissue-specific factors influence whether cells are susceptible to transformation by
erbB oncogenes. Avian fibroblasts resist transformation by insertionally activated
c-erbB (IAc-
erbB), whereas erythroblasts are transformed by this mutant of the epidermal growth factor receptor. In studies presented here, NIH/3T3 cells resisted transformation by IAc-
erbB. This finding indicates that the nonpermissiveness of fibroblasts is conserved between avian and murine species. Surprisingly, expression of IAc-
erbB blocked transformation by a
v-erbB allele. The
trans-dominant interference by IAc-
erbB occurred despite expression at levels lower than for v-
erbB. Together with previous reports, the results indicate that IAc-
erbB can exert opposite growth effects in different tissues. The switch from positive to negative growth regulation, which depends on the cellular context, provides novel insight into tissue-specific regulation of receptor tyrosine kinases. Evasion of cell-specific inhibition apparently contributes to the distinct tissue tropisms of various
erbB mutants.</description><subject>3T3 Cells</subject><subject>Alleles</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>DNA Primers - chemistry</subject><subject>Fibroblasts</subject><subject>Genes, Dominant</subject><subject>Genes, erbB-2</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Oncogenes</subject><subject>Phenotype</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1LAzEUDKLUWr16E3LytjXZTZPNsX5UCwVF6jlks28xspvUJC3037tLizfx9BjevGHeDELXlEwpIfxuZ4OfUilnU8pKdoLGlEiekYLRUzQmhOUZL_P8HF3E-EV6LAQZoZHggnPGxwjeIdqYtDOAk8froF1sfOh0st7hao-XLkIYgG7bPZ6bZHc6QY1NBqG6x8uINX70nXXaJfz2Cc6n_QawdXhhq-CrVscUL9FZo9sIV8c5QR-Lp_XDS7Z6fV4-zFeZKQRJWcNnIGnTG5s1pDAVyWshht-MbPKqNlIKVlHJCloQI0DwGgpTS25ySlnDeDFBtwfdTfDfW4hJdTYaaFvtwG-jEmJWiJL8T6RcipzLsidOD0QTfIwBGrUJttNhryhRQwFqKEANJtVQQH9wc1TeVh3Uv_Rj4v2-POyhz2FnIahoLPTx1zaASar29i_pH40NlVM</recordid><startdate>19950910</startdate><enddate>19950910</enddate><creator>Carter, T.H.</creator><creator>Dominguez, N.</creator><creator>Zeng, L.</creator><creator>Kung, H.-J.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19950910</creationdate><title>Resistance to Transformation by Insertionally Activated c-erbB Is a Dominant Phenotype in Fibroblasts</title><author>Carter, T.H. ; Dominguez, N. ; Zeng, L. ; Kung, H.-J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-f65e91f6465f03cb02d771995c9f2bdc9974b1943130c7e76de3cd96c2114f463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>3T3 Cells</topic><topic>Alleles</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>DNA Primers - chemistry</topic><topic>Fibroblasts</topic><topic>Genes, Dominant</topic><topic>Genes, erbB-2</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Oncogenes</topic><topic>Phenotype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carter, T.H.</creatorcontrib><creatorcontrib>Dominguez, N.</creatorcontrib><creatorcontrib>Zeng, L.</creatorcontrib><creatorcontrib>Kung, H.-J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carter, T.H.</au><au>Dominguez, N.</au><au>Zeng, L.</au><au>Kung, H.-J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistance to Transformation by Insertionally Activated c-erbB Is a Dominant Phenotype in Fibroblasts</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>1995-09-10</date><risdate>1995</risdate><volume>212</volume><issue>1</issue><spage>277</spage><epage>283</epage><pages>277-283</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>Tissue-specific factors influence whether cells are susceptible to transformation by
erbB oncogenes. Avian fibroblasts resist transformation by insertionally activated
c-erbB (IAc-
erbB), whereas erythroblasts are transformed by this mutant of the epidermal growth factor receptor. In studies presented here, NIH/3T3 cells resisted transformation by IAc-
erbB. This finding indicates that the nonpermissiveness of fibroblasts is conserved between avian and murine species. Surprisingly, expression of IAc-
erbB blocked transformation by a
v-erbB allele. The
trans-dominant interference by IAc-
erbB occurred despite expression at levels lower than for v-
erbB. Together with previous reports, the results indicate that IAc-
erbB can exert opposite growth effects in different tissues. The switch from positive to negative growth regulation, which depends on the cellular context, provides novel insight into tissue-specific regulation of receptor tyrosine kinases. Evasion of cell-specific inhibition apparently contributes to the distinct tissue tropisms of various
erbB mutants.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7676646</pmid><doi>10.1006/viro.1995.1484</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Virology (New York, N.Y.), 1995-09, Vol.212 (1), p.277-283 |
| issn | 0042-6822 1096-0341 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB Electronic Journals Library |
| subjects | 3T3 Cells Alleles Animals Base Sequence Cell Transformation, Neoplastic - genetics DNA Primers - chemistry Fibroblasts Genes, Dominant Genes, erbB-2 Mice Molecular Sequence Data Oncogenes Phenotype |
| title | Resistance to Transformation by Insertionally Activated c-erbB Is a Dominant Phenotype in Fibroblasts |
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