Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis

The secretion of insulin is controlled by the rate of glucose metabolism in the pancreatic β cells. As phosphorylation by glucokinase (GLK) appears to be the rate-limiting step for glucose catabolism in β cells, this enzyme may be the glucose sensor. To test this possibility and to resolve the relat...

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