Heparin Interferes with the Biological Effectiveness of Atriopeptin

The chromatographic mobility of atriopeptin-28 or of the prohormone is markedly altered by preincubation of the pep tides with heparin before separation on reverse-phase high performance liquid chromatography. Protamine prevented the heparin effect and reestablished the original migration pattern of...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1987-06, Vol.9 (6), p.607-610
Hauptverfasser:	WEI, YUEFANG, HOLMBERG, SANDRA W, LEAHY, KATHLEEN M, OLINS, PETER O, DEVINE, CATHERINE S, NEEDLEMAN, PHILIP
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrial Natriuretic Factor - antagonists & inhibitors Atrial Natriuretic Factor - metabolism Biological and medical sciences Blood Pressure - drug effects Blood. Blood coagulation. Reticuloendothelial system Chromatography, High Pressure Liquid Diuresis - drug effects Dose-Response Relationship, Drug Female Furosemide - pharmacology Heparin - metabolism Heparin - pharmacology Medical sciences Pharmacology. Drug treatments Protamines - pharmacology Rats Rats, Inbred Strains
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