Distribution of extravasated serum protein after cryoinjury in neonatal and adult rat brains

The sequelae of cryoinjury to unilateral cerebral cortex were compared in neonatal and adult rats. In neonatal rats, immunostaining for autologous albumin disclosed a wide spread of extravasated albumin in both hemispheres on day 1 and rapid clearance from the tissue by day 7, whereas in adults rats...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta neuropathologica 1995, Vol.89 (6), p.532-536
Hauptverfasser: SUZUKI, M, IWASAKI, Y, UMEZAWA, K, MOTOHASHI, O, SHIDA, N
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 536
container_issue 6
container_start_page 532
container_title Acta neuropathologica
container_volume 89
creator SUZUKI, M
IWASAKI, Y
UMEZAWA, K
MOTOHASHI, O
SHIDA, N
description The sequelae of cryoinjury to unilateral cerebral cortex were compared in neonatal and adult rats. In neonatal rats, immunostaining for autologous albumin disclosed a wide spread of extravasated albumin in both hemispheres on day 1 and rapid clearance from the tissue by day 7, whereas in adults rats, the distribution of albumin had progressively increased by day 7 and was then restricted to the injury site by day 14. Horseradish peroxidase tracing revealed a leakage of serum proteins by day 3 in neonates and by day 7 in adults. The rapid clearance of serum proteins from the neonatal brain tissue appeared to be promoted by vimentin-positive radial glia in the subpial and periventricular regions. A possible causal relationship between the rapid clearance of serum proteins and unique outcome of the cryoinjury in the neonatal brain is discussed.
doi_str_mv 10.1007/BF00571508
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77536323</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16852409</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-171b8e9da1f7f7fe812a87496955bcff3709c0047da1bbdeb6a116924e84dddb3</originalsourceid><addsrcrecordid>eNqFkM1LxDAQxYMo67p68S7kIB6EatI0Hz3q6qqw4EVvQpk0KWTptmuSivvfG9myHmUOw8z7MfN4CJ1TckMJkbf3C0K4pJyoAzSlBcszwhk7RFNCCM0Ey_NjdBLCKk25LPgETaSQQhE1RR8PLkTv9BBd3-G-wfY7eviCANEaHKwf1njj-2hdh6GJ1uPab3vXrQa_xWnX2b6DCC2GzmAwQxuxh4i1B9eFU3TUQBvs2dhn6H3x-DZ_zpavTy_zu2VWsyKPGZVUK1saoI1MZRXNQcmiFCXnum4aJklZE1LIRGhtrBZAqSjzwqrCGKPZDF3t7iann4MNsVq7UNu2hWRvCJWUnKUU2L8gFYrnBSkTeL0Da9-H4G1Tbbxbg99WlFS_mVd_mSf4Yrw66LU1e3QMOemXow6hhrbx0NUu7DHGGRXp5w_9HomI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16852409</pqid></control><display><type>article</type><title>Distribution of extravasated serum protein after cryoinjury in neonatal and adult rat brains</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>SUZUKI, M ; IWASAKI, Y ; UMEZAWA, K ; MOTOHASHI, O ; SHIDA, N</creator><creatorcontrib>SUZUKI, M ; IWASAKI, Y ; UMEZAWA, K ; MOTOHASHI, O ; SHIDA, N</creatorcontrib><description>The sequelae of cryoinjury to unilateral cerebral cortex were compared in neonatal and adult rats. In neonatal rats, immunostaining for autologous albumin disclosed a wide spread of extravasated albumin in both hemispheres on day 1 and rapid clearance from the tissue by day 7, whereas in adults rats, the distribution of albumin had progressively increased by day 7 and was then restricted to the injury site by day 14. Horseradish peroxidase tracing revealed a leakage of serum proteins by day 3 in neonates and by day 7 in adults. The rapid clearance of serum proteins from the neonatal brain tissue appeared to be promoted by vimentin-positive radial glia in the subpial and periventricular regions. A possible causal relationship between the rapid clearance of serum proteins and unique outcome of the cryoinjury in the neonatal brain is discussed.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/BF00571508</identifier><identifier>PMID: 7676808</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Astrocytes - metabolism ; Biological and medical sciences ; Blood Proteins - metabolism ; Blood-Brain Barrier - physiology ; Brain - growth &amp; development ; Brain Chemistry - physiology ; Brain Injuries - metabolism ; Freezing ; Glial Fibrillary Acidic Protein - metabolism ; Horseradish Peroxidase ; Immunohistochemistry ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Male ; Medical sciences ; Necrosis - pathology ; Rats ; Rats, Sprague-Dawley ; Serum Albumin - metabolism ; Traumas. Diseases due to physical agents ; Vimentin - metabolism</subject><ispartof>Acta neuropathologica, 1995, Vol.89 (6), p.532-536</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-171b8e9da1f7f7fe812a87496955bcff3709c0047da1bbdeb6a116924e84dddb3</citedby><cites>FETCH-LOGICAL-c342t-171b8e9da1f7f7fe812a87496955bcff3709c0047da1bbdeb6a116924e84dddb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=3531609$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7676808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUZUKI, M</creatorcontrib><creatorcontrib>IWASAKI, Y</creatorcontrib><creatorcontrib>UMEZAWA, K</creatorcontrib><creatorcontrib>MOTOHASHI, O</creatorcontrib><creatorcontrib>SHIDA, N</creatorcontrib><title>Distribution of extravasated serum protein after cryoinjury in neonatal and adult rat brains</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>The sequelae of cryoinjury to unilateral cerebral cortex were compared in neonatal and adult rats. In neonatal rats, immunostaining for autologous albumin disclosed a wide spread of extravasated albumin in both hemispheres on day 1 and rapid clearance from the tissue by day 7, whereas in adults rats, the distribution of albumin had progressively increased by day 7 and was then restricted to the injury site by day 14. Horseradish peroxidase tracing revealed a leakage of serum proteins by day 3 in neonates and by day 7 in adults. The rapid clearance of serum proteins from the neonatal brain tissue appeared to be promoted by vimentin-positive radial glia in the subpial and periventricular regions. A possible causal relationship between the rapid clearance of serum proteins and unique outcome of the cryoinjury in the neonatal brain is discussed.</description><subject>Animals</subject><subject>Astrocytes - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - metabolism</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Brain - growth &amp; development</subject><subject>Brain Chemistry - physiology</subject><subject>Brain Injuries - metabolism</subject><subject>Freezing</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Horseradish Peroxidase</subject><subject>Immunohistochemistry</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Necrosis - pathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serum Albumin - metabolism</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Vimentin - metabolism</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LxDAQxYMo67p68S7kIB6EatI0Hz3q6qqw4EVvQpk0KWTptmuSivvfG9myHmUOw8z7MfN4CJ1TckMJkbf3C0K4pJyoAzSlBcszwhk7RFNCCM0Ey_NjdBLCKk25LPgETaSQQhE1RR8PLkTv9BBd3-G-wfY7eviCANEaHKwf1njj-2hdh6GJ1uPab3vXrQa_xWnX2b6DCC2GzmAwQxuxh4i1B9eFU3TUQBvs2dhn6H3x-DZ_zpavTy_zu2VWsyKPGZVUK1saoI1MZRXNQcmiFCXnum4aJklZE1LIRGhtrBZAqSjzwqrCGKPZDF3t7iann4MNsVq7UNu2hWRvCJWUnKUU2L8gFYrnBSkTeL0Da9-H4G1Tbbxbg99WlFS_mVd_mSf4Yrw66LU1e3QMOemXow6hhrbx0NUu7DHGGRXp5w_9HomI</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>SUZUKI, M</creator><creator>IWASAKI, Y</creator><creator>UMEZAWA, K</creator><creator>MOTOHASHI, O</creator><creator>SHIDA, N</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Distribution of extravasated serum protein after cryoinjury in neonatal and adult rat brains</title><author>SUZUKI, M ; IWASAKI, Y ; UMEZAWA, K ; MOTOHASHI, O ; SHIDA, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-171b8e9da1f7f7fe812a87496955bcff3709c0047da1bbdeb6a116924e84dddb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Astrocytes - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - metabolism</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Brain - growth &amp; development</topic><topic>Brain Chemistry - physiology</topic><topic>Brain Injuries - metabolism</topic><topic>Freezing</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Horseradish Peroxidase</topic><topic>Immunohistochemistry</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Necrosis - pathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serum Albumin - metabolism</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Vimentin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUZUKI, M</creatorcontrib><creatorcontrib>IWASAKI, Y</creatorcontrib><creatorcontrib>UMEZAWA, K</creatorcontrib><creatorcontrib>MOTOHASHI, O</creatorcontrib><creatorcontrib>SHIDA, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUZUKI, M</au><au>IWASAKI, Y</au><au>UMEZAWA, K</au><au>MOTOHASHI, O</au><au>SHIDA, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of extravasated serum protein after cryoinjury in neonatal and adult rat brains</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1995</date><risdate>1995</risdate><volume>89</volume><issue>6</issue><spage>532</spage><epage>536</epage><pages>532-536</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>The sequelae of cryoinjury to unilateral cerebral cortex were compared in neonatal and adult rats. In neonatal rats, immunostaining for autologous albumin disclosed a wide spread of extravasated albumin in both hemispheres on day 1 and rapid clearance from the tissue by day 7, whereas in adults rats, the distribution of albumin had progressively increased by day 7 and was then restricted to the injury site by day 14. Horseradish peroxidase tracing revealed a leakage of serum proteins by day 3 in neonates and by day 7 in adults. The rapid clearance of serum proteins from the neonatal brain tissue appeared to be promoted by vimentin-positive radial glia in the subpial and periventricular regions. A possible causal relationship between the rapid clearance of serum proteins and unique outcome of the cryoinjury in the neonatal brain is discussed.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>7676808</pmid><doi>10.1007/BF00571508</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0001-6322
ispartof Acta neuropathologica, 1995, Vol.89 (6), p.532-536
issn 0001-6322
1432-0533
language eng
recordid cdi_proquest_miscellaneous_77536323
source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Animals
Astrocytes - metabolism
Biological and medical sciences
Blood Proteins - metabolism
Blood-Brain Barrier - physiology
Brain - growth & development
Brain Chemistry - physiology
Brain Injuries - metabolism
Freezing
Glial Fibrillary Acidic Protein - metabolism
Horseradish Peroxidase
Immunohistochemistry
Injuries of the nervous system and the skull. Diseases due to physical agents
Male
Medical sciences
Necrosis - pathology
Rats
Rats, Sprague-Dawley
Serum Albumin - metabolism
Traumas. Diseases due to physical agents
Vimentin - metabolism
title Distribution of extravasated serum protein after cryoinjury in neonatal and adult rat brains
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T03%3A15%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Distribution%20of%20extravasated%20serum%20protein%20after%20cryoinjury%20in%20neonatal%20and%20adult%20rat%20brains&rft.jtitle=Acta%20neuropathologica&rft.au=SUZUKI,%20M&rft.date=1995&rft.volume=89&rft.issue=6&rft.spage=532&rft.epage=536&rft.pages=532-536&rft.issn=0001-6322&rft.eissn=1432-0533&rft.coden=ANPTAL&rft_id=info:doi/10.1007/BF00571508&rft_dat=%3Cproquest_cross%3E16852409%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16852409&rft_id=info:pmid/7676808&rfr_iscdi=true