Distribution of extravasated serum protein after cryoinjury in neonatal and adult rat brains
The sequelae of cryoinjury to unilateral cerebral cortex were compared in neonatal and adult rats. In neonatal rats, immunostaining for autologous albumin disclosed a wide spread of extravasated albumin in both hemispheres on day 1 and rapid clearance from the tissue by day 7, whereas in adults rats...
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Veröffentlicht in: | Acta neuropathologica 1995, Vol.89 (6), p.532-536 |
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creator | SUZUKI, M IWASAKI, Y UMEZAWA, K MOTOHASHI, O SHIDA, N |
description | The sequelae of cryoinjury to unilateral cerebral cortex were compared in neonatal and adult rats. In neonatal rats, immunostaining for autologous albumin disclosed a wide spread of extravasated albumin in both hemispheres on day 1 and rapid clearance from the tissue by day 7, whereas in adults rats, the distribution of albumin had progressively increased by day 7 and was then restricted to the injury site by day 14. Horseradish peroxidase tracing revealed a leakage of serum proteins by day 3 in neonates and by day 7 in adults. The rapid clearance of serum proteins from the neonatal brain tissue appeared to be promoted by vimentin-positive radial glia in the subpial and periventricular regions. A possible causal relationship between the rapid clearance of serum proteins and unique outcome of the cryoinjury in the neonatal brain is discussed. |
doi_str_mv | 10.1007/BF00571508 |
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In neonatal rats, immunostaining for autologous albumin disclosed a wide spread of extravasated albumin in both hemispheres on day 1 and rapid clearance from the tissue by day 7, whereas in adults rats, the distribution of albumin had progressively increased by day 7 and was then restricted to the injury site by day 14. Horseradish peroxidase tracing revealed a leakage of serum proteins by day 3 in neonates and by day 7 in adults. The rapid clearance of serum proteins from the neonatal brain tissue appeared to be promoted by vimentin-positive radial glia in the subpial and periventricular regions. A possible causal relationship between the rapid clearance of serum proteins and unique outcome of the cryoinjury in the neonatal brain is discussed.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/BF00571508</identifier><identifier>PMID: 7676808</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Astrocytes - metabolism ; Biological and medical sciences ; Blood Proteins - metabolism ; Blood-Brain Barrier - physiology ; Brain - growth & development ; Brain Chemistry - physiology ; Brain Injuries - metabolism ; Freezing ; Glial Fibrillary Acidic Protein - metabolism ; Horseradish Peroxidase ; Immunohistochemistry ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Male ; Medical sciences ; Necrosis - pathology ; Rats ; Rats, Sprague-Dawley ; Serum Albumin - metabolism ; Traumas. 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In neonatal rats, immunostaining for autologous albumin disclosed a wide spread of extravasated albumin in both hemispheres on day 1 and rapid clearance from the tissue by day 7, whereas in adults rats, the distribution of albumin had progressively increased by day 7 and was then restricted to the injury site by day 14. Horseradish peroxidase tracing revealed a leakage of serum proteins by day 3 in neonates and by day 7 in adults. The rapid clearance of serum proteins from the neonatal brain tissue appeared to be promoted by vimentin-positive radial glia in the subpial and periventricular regions. A possible causal relationship between the rapid clearance of serum proteins and unique outcome of the cryoinjury in the neonatal brain is discussed.</description><subject>Animals</subject><subject>Astrocytes - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - metabolism</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Brain - growth & development</subject><subject>Brain Chemistry - physiology</subject><subject>Brain Injuries - metabolism</subject><subject>Freezing</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Horseradish Peroxidase</subject><subject>Immunohistochemistry</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Necrosis - pathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serum Albumin - metabolism</subject><subject>Traumas. 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Diseases due to physical agents</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Necrosis - pathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serum Albumin - metabolism</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Vimentin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUZUKI, M</creatorcontrib><creatorcontrib>IWASAKI, Y</creatorcontrib><creatorcontrib>UMEZAWA, K</creatorcontrib><creatorcontrib>MOTOHASHI, O</creatorcontrib><creatorcontrib>SHIDA, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUZUKI, M</au><au>IWASAKI, Y</au><au>UMEZAWA, K</au><au>MOTOHASHI, O</au><au>SHIDA, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of extravasated serum protein after cryoinjury in neonatal and adult rat brains</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1995</date><risdate>1995</risdate><volume>89</volume><issue>6</issue><spage>532</spage><epage>536</epage><pages>532-536</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>The sequelae of cryoinjury to unilateral cerebral cortex were compared in neonatal and adult rats. In neonatal rats, immunostaining for autologous albumin disclosed a wide spread of extravasated albumin in both hemispheres on day 1 and rapid clearance from the tissue by day 7, whereas in adults rats, the distribution of albumin had progressively increased by day 7 and was then restricted to the injury site by day 14. Horseradish peroxidase tracing revealed a leakage of serum proteins by day 3 in neonates and by day 7 in adults. The rapid clearance of serum proteins from the neonatal brain tissue appeared to be promoted by vimentin-positive radial glia in the subpial and periventricular regions. A possible causal relationship between the rapid clearance of serum proteins and unique outcome of the cryoinjury in the neonatal brain is discussed.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>7676808</pmid><doi>10.1007/BF00571508</doi><tpages>5</tpages></addata></record> |
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subjects | Animals Astrocytes - metabolism Biological and medical sciences Blood Proteins - metabolism Blood-Brain Barrier - physiology Brain - growth & development Brain Chemistry - physiology Brain Injuries - metabolism Freezing Glial Fibrillary Acidic Protein - metabolism Horseradish Peroxidase Immunohistochemistry Injuries of the nervous system and the skull. Diseases due to physical agents Male Medical sciences Necrosis - pathology Rats Rats, Sprague-Dawley Serum Albumin - metabolism Traumas. Diseases due to physical agents Vimentin - metabolism |
title | Distribution of extravasated serum protein after cryoinjury in neonatal and adult rat brains |
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