Eosinophil cationic protein in serum and nasal washes from wheezing infants and children
Objective: To compare eosinophil counts and concentrations of eosinophil cationic protein (ECP) in serum and nasal wash fluid from wheezing infants and children with those from age-matched children without respiratory tract symptoms Design: A case-control study of 71 children treated for wheezing an...
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| Veröffentlicht in: | The Journal of pediatrics 1995-10, Vol.127 (4), p.558-564 |
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| container_title | The Journal of pediatrics |
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| creator | Ingram, Jim Mark Rakes, Gary P. Hoover, Gates E. Platts-Mills, Thomas A.E. Heymann, Peter W. |
| description | Objective: To compare eosinophil counts and concentrations of eosinophil cationic protein (ECP) in serum and nasal wash fluid from wheezing infants and children with those from age-matched children without respiratory tract symptoms
Design: A case-control study of 71 children treated for wheezing and 59 control subjects in the University of Virginia Pediatric Emergency Department. The patients ranged from 2 months to 16 years of age. Eosinophil numbers and ECP concentrations were assessed in serum and nasal washes. Total serum IgE was measured and the radioallergosorbent test was used to measure IgE antibody to common inhalant allergens.
Results: Among children less than the age of 2 years, markedly elevated levels of ECP (>200 ng/ml) were measured in nasal washes from 9 (41%) of 22 wheezing patients and 1 (6%) of 17 control subjects (
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| doi_str_mv | 10.1016/S0022-3476(95)70112-5 |
| format | Article |
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Design: A case-control study of 71 children treated for wheezing and 59 control subjects in the University of Virginia Pediatric Emergency Department. The patients ranged from 2 months to 16 years of age. Eosinophil numbers and ECP concentrations were assessed in serum and nasal washes. Total serum IgE was measured and the radioallergosorbent test was used to measure IgE antibody to common inhalant allergens.
Results: Among children less than the age of 2 years, markedly elevated levels of ECP (>200 ng/ml) were measured in nasal washes from 9 (41%) of 22 wheezing patients and 1 (6%) of 17 control subjects (
p <0.03). None of these children had a positive radioallergosorbent test result for IgE antibody to common aeroallergens or a nasal smear containing 10% eosinophils. Few of the wheezing children under 2 years of age had either increased concentrations of total IgE or ECP in their serum or an elevated total blood eosinophil count. After the age of 2 years, the percentage of patients with nasal ECP levels greater than 200 ng/ml was also significantly higher in wheezing children than in control subjects (
p <0.001), and a positive correlation was observed between ECP concentrations in their nasal washes and other eosinophil responses (total blood eosinophil counts, serum ECP levels, and nasal eosinophil counts).
Conclusion: Increased concentrations of ECP were detected in nasal washes from wheezing infants and children, indicating that eosinophils may contribute to the pathogenesis of airway inflammation in some children who wheeze early in life. (J P
EDIATR 1995;127:558-64)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(95)70112-5</identifier><identifier>PMID: 7562276</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Biological and medical sciences ; Blood Proteins - analysis ; Cations - analysis ; Child ; Child, Preschool ; Chronic obstructive pulmonary disease, asthma ; Eosinophils ; Humans ; Immunoglobulin E - blood ; Infant ; Medical sciences ; Nasal Lavage Fluid - chemistry ; Pneumology ; Respiratory Sounds ; Respiratory Syncytial Viruses - isolation & purification ; Respiratory Tract Diseases - virology</subject><ispartof>The Journal of pediatrics, 1995-10, Vol.127 (4), p.558-564</ispartof><rights>1995 Mosby, Inc.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-59712b14839e3ee4ab46af07905242f8fd7353724f99cae280d23b8cb0dfe4f83</citedby><cites>FETCH-LOGICAL-c455t-59712b14839e3ee4ab46af07905242f8fd7353724f99cae280d23b8cb0dfe4f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(95)70112-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2896068$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7562276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ingram, Jim Mark</creatorcontrib><creatorcontrib>Rakes, Gary P.</creatorcontrib><creatorcontrib>Hoover, Gates E.</creatorcontrib><creatorcontrib>Platts-Mills, Thomas A.E.</creatorcontrib><creatorcontrib>Heymann, Peter W.</creatorcontrib><title>Eosinophil cationic protein in serum and nasal washes from wheezing infants and children</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective: To compare eosinophil counts and concentrations of eosinophil cationic protein (ECP) in serum and nasal wash fluid from wheezing infants and children with those from age-matched children without respiratory tract symptoms
Design: A case-control study of 71 children treated for wheezing and 59 control subjects in the University of Virginia Pediatric Emergency Department. The patients ranged from 2 months to 16 years of age. Eosinophil numbers and ECP concentrations were assessed in serum and nasal washes. Total serum IgE was measured and the radioallergosorbent test was used to measure IgE antibody to common inhalant allergens.
Results: Among children less than the age of 2 years, markedly elevated levels of ECP (>200 ng/ml) were measured in nasal washes from 9 (41%) of 22 wheezing patients and 1 (6%) of 17 control subjects (
p <0.03). None of these children had a positive radioallergosorbent test result for IgE antibody to common aeroallergens or a nasal smear containing 10% eosinophils. Few of the wheezing children under 2 years of age had either increased concentrations of total IgE or ECP in their serum or an elevated total blood eosinophil count. After the age of 2 years, the percentage of patients with nasal ECP levels greater than 200 ng/ml was also significantly higher in wheezing children than in control subjects (
p <0.001), and a positive correlation was observed between ECP concentrations in their nasal washes and other eosinophil responses (total blood eosinophil counts, serum ECP levels, and nasal eosinophil counts).
Conclusion: Increased concentrations of ECP were detected in nasal washes from wheezing infants and children, indicating that eosinophils may contribute to the pathogenesis of airway inflammation in some children who wheeze early in life. (J P
EDIATR 1995;127:558-64)</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - analysis</subject><subject>Cations - analysis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Eosinophils</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Infant</subject><subject>Medical sciences</subject><subject>Nasal Lavage Fluid - chemistry</subject><subject>Pneumology</subject><subject>Respiratory Sounds</subject><subject>Respiratory Syncytial Viruses - isolation & purification</subject><subject>Respiratory Tract Diseases - virology</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFEEQhhtR4ib6EwJzEImH0eqv6emTSIhRCOQQBW9NT0-12zLTs3bNGsyvd_aDvQoFdainql4exi45vOfAmw8PAELUUpnmyup3BjgXtX7GVhysqZtWyudsdUJesnOiXwBgFcAZOzO6EcI0K_bjZqKUp806DVXwc5pyCtWmTDOmXC1FWLZj5XNfZU9-qB49rZGqWKaxelwjPqX8c-GizzPtsbBc6gvmV-xF9APh62O_YN8_33y7_lLf3d9-vf50Vwel9Vxra7jouGqlRYmofKcaH8FY0EKJ2MbeSC2NUNHa4FG00AvZtaGDPqKKrbxgbw93l9C_t0izGxMFHAafcdqSM0ZLbTksoD6AoUxEBaPblDT68tdxcDujbm_U7XQ5q93eqNPL3uXxwbYbsT9tHRUu8zfHuafgh1h8DolOmGhtA80u58cDhouMPwmLo5AwB-xTwTC7fkr_CfIPZPCSpA</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>Ingram, Jim Mark</creator><creator>Rakes, Gary P.</creator><creator>Hoover, Gates E.</creator><creator>Platts-Mills, Thomas A.E.</creator><creator>Heymann, Peter W.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951001</creationdate><title>Eosinophil cationic protein in serum and nasal washes from wheezing infants and children</title><author>Ingram, Jim Mark ; Rakes, Gary P. ; Hoover, Gates E. ; Platts-Mills, Thomas A.E. ; Heymann, Peter W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-59712b14839e3ee4ab46af07905242f8fd7353724f99cae280d23b8cb0dfe4f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - analysis</topic><topic>Cations - analysis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Eosinophils</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Infant</topic><topic>Medical sciences</topic><topic>Nasal Lavage Fluid - chemistry</topic><topic>Pneumology</topic><topic>Respiratory Sounds</topic><topic>Respiratory Syncytial Viruses - isolation & purification</topic><topic>Respiratory Tract Diseases - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ingram, Jim Mark</creatorcontrib><creatorcontrib>Rakes, Gary P.</creatorcontrib><creatorcontrib>Hoover, Gates E.</creatorcontrib><creatorcontrib>Platts-Mills, Thomas A.E.</creatorcontrib><creatorcontrib>Heymann, Peter W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ingram, Jim Mark</au><au>Rakes, Gary P.</au><au>Hoover, Gates E.</au><au>Platts-Mills, Thomas A.E.</au><au>Heymann, Peter W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eosinophil cationic protein in serum and nasal washes from wheezing infants and children</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>127</volume><issue>4</issue><spage>558</spage><epage>564</epage><pages>558-564</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objective: To compare eosinophil counts and concentrations of eosinophil cationic protein (ECP) in serum and nasal wash fluid from wheezing infants and children with those from age-matched children without respiratory tract symptoms
Design: A case-control study of 71 children treated for wheezing and 59 control subjects in the University of Virginia Pediatric Emergency Department. The patients ranged from 2 months to 16 years of age. Eosinophil numbers and ECP concentrations were assessed in serum and nasal washes. Total serum IgE was measured and the radioallergosorbent test was used to measure IgE antibody to common inhalant allergens.
Results: Among children less than the age of 2 years, markedly elevated levels of ECP (>200 ng/ml) were measured in nasal washes from 9 (41%) of 22 wheezing patients and 1 (6%) of 17 control subjects (
p <0.03). None of these children had a positive radioallergosorbent test result for IgE antibody to common aeroallergens or a nasal smear containing 10% eosinophils. Few of the wheezing children under 2 years of age had either increased concentrations of total IgE or ECP in their serum or an elevated total blood eosinophil count. After the age of 2 years, the percentage of patients with nasal ECP levels greater than 200 ng/ml was also significantly higher in wheezing children than in control subjects (
p <0.001), and a positive correlation was observed between ECP concentrations in their nasal washes and other eosinophil responses (total blood eosinophil counts, serum ECP levels, and nasal eosinophil counts).
Conclusion: Increased concentrations of ECP were detected in nasal washes from wheezing infants and children, indicating that eosinophils may contribute to the pathogenesis of airway inflammation in some children who wheeze early in life. (J P
EDIATR 1995;127:558-64)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>7562276</pmid><doi>10.1016/S0022-3476(95)70112-5</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Blood Proteins - analysis Cations - analysis Child Child, Preschool Chronic obstructive pulmonary disease, asthma Eosinophils Humans Immunoglobulin E - blood Infant Medical sciences Nasal Lavage Fluid - chemistry Pneumology Respiratory Sounds Respiratory Syncytial Viruses - isolation & purification Respiratory Tract Diseases - virology |
| title | Eosinophil cationic protein in serum and nasal washes from wheezing infants and children |
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