Maduropeptin: An Antitumor Chromoprotein with Selective Protease Activity and DNA Cleaving Properties

Maduropeptin (MDP) is a recently isolated antitumor antibiotic, consisting of an enediyne-containing chromophore embedded in a highly acidic protein. This holoantibiotic damages duplex DNA in vitro, producing a mixture of single- and double-strand breaks at selected sites. The chromophore, isolated...

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