Structure of a tetrahedral transition state complex of alpha-chymotrypsin dimer at 1.8-A resolution

A 1.8-A resolution x-ray crystallographic restrained least squares refinement has been carried out on the phenylethane boronic acid (PEBA) complex of alpha-chymotrypsin dimer (alpha-CHT), and it has been compared to the 1.67-A resolution structure of the native enzyme. PEBA has a high binding affini...

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Veröffentlicht in:	The Journal of biological chemistry 1987-06, Vol.262 (16), p.7737-7743
Hauptverfasser:	Tulinsky, A, Blevins, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Boronic Acids - metabolism Chymotrypsin - metabolism Crystalline structure Fundamental and applied biological sciences. Psychology Macromolecular Substances Models, Molecular Molecular biophysics Molecular Conformation Protein Binding Protein Conformation Structure in molecular biology X-Ray Diffraction
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