Modulation of the Grb2-associated protein complex in human CD4+ T cells by receptor activation

A panel of human CD4+ T cell clones was utilized to dissect and analyze the biochemical consequences of activation of CD3 or CD28. To molecularly characterize receptor-activated proximal signaling events, tyrosine-phosphorylated proteins co-precipitating with a Grb2 fusion protein after receptor act...

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Veröffentlicht in:	The Journal of immunology (1950) 1995-10, Vol.155 (8), p.3815-3822
Hauptverfasser:	Lahesmaa, R, Allsup, A, Soderberg, C, Jackman, J, Findell, P, Peltz, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing AIDS/HIV CD4-Positive T-Lymphocytes - immunology Clone Cells Cyclic AMP - physiology GRB2 Adaptor Protein Humans Lymphocyte Activation Proteins - metabolism Receptor, Epidermal Growth Factor - metabolism Receptors, Antigen, T-Cell - physiology Signal Transduction Th1 Cells - immunology
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