In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release
The effect of adenohypophysial hormones on rat pineal melatonin content and release was examined in vitro. Medium concentration of radioimmunoassayable melatonin decreased after a 6 h exposure to 1–100 ng/ml FSH; pineal levels of melatonin were only decreased by 100 ng/ml FSH. LH (1–100 ng/ml) augme...
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| Veröffentlicht in: | Molecular and cellular endocrinology 1987-03, Vol.50 (1), p.23-27 |
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| container_title | Molecular and cellular endocrinology |
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| creator | Vacas, Maria I. Sarmiento, Maria I.Keller Pereyra, Elba N. Etchegoyen, Graciela S. Cardinali, D.P. |
| description | The effect of adenohypophysial hormones on rat pineal melatonin content and release was examined in vitro. Medium concentration of radioimmunoassayable melatonin decreased after a 6 h exposure to 1–100 ng/ml FSH; pineal levels of melatonin were only decreased by 100 ng/ml FSH. LH (1–100 ng/ml) augmented significantly medium melatonin concentration, tissue levels being increased at 10 ng/ml LH. Parallel increases of explant and medium melatonin content were found after exposure to 1–100 ng/ml TSH. At the smallest concentration employed (1 ng/ml) prolactin increased melatonin content and release while at 100 ng/ml a significant depression of both parameters was found. Growth hormone (1–10 ng/ml) augmented melatonin levels in medium but failed to modify them at 100 ng/ml, although at this concentration tissue melatonin levels increased. ACTH did not modify pineal melatonin synthesis in vitro. |
| doi_str_mv | 10.1016/0303-7207(87)90073-6 |
| format | Article |
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Medium concentration of radioimmunoassayable melatonin decreased after a 6 h exposure to 1–100 ng/ml FSH; pineal levels of melatonin were only decreased by 100 ng/ml FSH. LH (1–100 ng/ml) augmented significantly medium melatonin concentration, tissue levels being increased at 10 ng/ml LH. Parallel increases of explant and medium melatonin content were found after exposure to 1–100 ng/ml TSH. At the smallest concentration employed (1 ng/ml) prolactin increased melatonin content and release while at 100 ng/ml a significant depression of both parameters was found. Growth hormone (1–10 ng/ml) augmented melatonin levels in medium but failed to modify them at 100 ng/ml, although at this concentration tissue melatonin levels increased. ACTH did not modify pineal melatonin synthesis in vitro.</description><identifier>ISSN: 0303-7207</identifier><identifier>EISSN: 1872-8057</identifier><identifier>DOI: 10.1016/0303-7207(87)90073-6</identifier><identifier>PMID: 3034698</identifier><identifier>CODEN: MCEND6</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>ACTH ; Adrenocorticotropic Hormone - pharmacology ; Animals ; Biological and medical sciences ; Follicle Stimulating Hormone - pharmacology ; FSH ; Fundamental and applied biological sciences. Psychology ; Growth hormone ; Growth Hormone - pharmacology ; Hormones and neuropeptides. Regulation ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Luteinizing Hormone - pharmacology ; Male ; Melatonin - metabolism ; Organ Culture Techniques ; Pineal Gland - drug effects ; Pineal Gland - metabolism ; Pineal organ culture ; Pituitary Hormones, Anterior - pharmacology ; Prolactin ; Prolactin - pharmacology ; Rats ; Thyrotropin - pharmacology ; TSH ; Vertebrates: endocrinology</subject><ispartof>Molecular and cellular endocrinology, 1987-03, Vol.50 (1), p.23-27</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-1ae86555b848900dc1e0a2e1d4efad30733b5e94fe4213858c60afc7037669e03</citedby><cites>FETCH-LOGICAL-c332t-1ae86555b848900dc1e0a2e1d4efad30733b5e94fe4213858c60afc7037669e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0303720787900736$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7430070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3034698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vacas, Maria I.</creatorcontrib><creatorcontrib>Sarmiento, Maria I.Keller</creatorcontrib><creatorcontrib>Pereyra, Elba N.</creatorcontrib><creatorcontrib>Etchegoyen, Graciela S.</creatorcontrib><creatorcontrib>Cardinali, D.P.</creatorcontrib><title>In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release</title><title>Molecular and cellular endocrinology</title><addtitle>Mol Cell Endocrinol</addtitle><description>The effect of adenohypophysial hormones on rat pineal melatonin content and release was examined in vitro. Medium concentration of radioimmunoassayable melatonin decreased after a 6 h exposure to 1–100 ng/ml FSH; pineal levels of melatonin were only decreased by 100 ng/ml FSH. LH (1–100 ng/ml) augmented significantly medium melatonin concentration, tissue levels being increased at 10 ng/ml LH. Parallel increases of explant and medium melatonin content were found after exposure to 1–100 ng/ml TSH. At the smallest concentration employed (1 ng/ml) prolactin increased melatonin content and release while at 100 ng/ml a significant depression of both parameters was found. Growth hormone (1–10 ng/ml) augmented melatonin levels in medium but failed to modify them at 100 ng/ml, although at this concentration tissue melatonin levels increased. ACTH did not modify pineal melatonin synthesis in vitro.</description><subject>ACTH</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Follicle Stimulating Hormone - pharmacology</subject><subject>FSH</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth hormone</subject><subject>Growth Hormone - pharmacology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Luteinizing Hormone - pharmacology</subject><subject>Male</subject><subject>Melatonin - metabolism</subject><subject>Organ Culture Techniques</subject><subject>Pineal Gland - drug effects</subject><subject>Pineal Gland - metabolism</subject><subject>Pineal organ culture</subject><subject>Pituitary Hormones, Anterior - pharmacology</subject><subject>Prolactin</subject><subject>Prolactin - pharmacology</subject><subject>Rats</subject><subject>Thyrotropin - pharmacology</subject><subject>TSH</subject><subject>Vertebrates: endocrinology</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrHCEYhqU0JNtN_kELHkpJD5Po6Kh7CZSQNgsLuSSHnMR1PlnLjE50dmH_fZzsssf2JHzf44vvI0JfKbmhhIpbwgirZE3ktZI_F4RIVolPaEaVrCtFGvkZzU7IBfqS819SoKZW5-i8zLlYqBl6XQa882OKGJwDO2YcHTYthLjZD3HY7LM3Hd7E1McAZRlwMiMefIAy7qEzYww-YBvDCGHEJrQ4QQcmwyU6c6bLcHU85-jl98Pz_WO1evqzvP-1qixj9VhRA0o0TbNWXJUSraVATA205eBMy0ortm5gwR3wmjLVKCuIcVYSJoVYAGFz9OOQO6T4toU86t5nC11nAsRt1lI2jHEm_gtSLhjhnBeQH0CbYs4JnB6S703aa0r0pF5PXvXkVSupP9TrKf_bMX-77qE9XTq6Lvvvx73J1nQumWB9PmGSsxI09bk7YFCk7Twkna2HYKH1qXyQbqP_9zveAX8tnzs</recordid><startdate>198703</startdate><enddate>198703</enddate><creator>Vacas, Maria I.</creator><creator>Sarmiento, Maria I.Keller</creator><creator>Pereyra, Elba N.</creator><creator>Etchegoyen, Graciela S.</creator><creator>Cardinali, D.P.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>198703</creationdate><title>In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release</title><author>Vacas, Maria I. ; Sarmiento, Maria I.Keller ; Pereyra, Elba N. ; Etchegoyen, Graciela S. ; Cardinali, D.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-1ae86555b848900dc1e0a2e1d4efad30733b5e94fe4213858c60afc7037669e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>ACTH</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Follicle Stimulating Hormone - pharmacology</topic><topic>FSH</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth hormone</topic><topic>Growth Hormone - pharmacology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Luteinizing Hormone - pharmacology</topic><topic>Male</topic><topic>Melatonin - metabolism</topic><topic>Organ Culture Techniques</topic><topic>Pineal Gland - drug effects</topic><topic>Pineal Gland - metabolism</topic><topic>Pineal organ culture</topic><topic>Pituitary Hormones, Anterior - pharmacology</topic><topic>Prolactin</topic><topic>Prolactin - pharmacology</topic><topic>Rats</topic><topic>Thyrotropin - pharmacology</topic><topic>TSH</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vacas, Maria I.</creatorcontrib><creatorcontrib>Sarmiento, Maria I.Keller</creatorcontrib><creatorcontrib>Pereyra, Elba N.</creatorcontrib><creatorcontrib>Etchegoyen, Graciela S.</creatorcontrib><creatorcontrib>Cardinali, D.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vacas, Maria I.</au><au>Sarmiento, Maria I.Keller</au><au>Pereyra, Elba N.</au><au>Etchegoyen, Graciela S.</au><au>Cardinali, D.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release</atitle><jtitle>Molecular and cellular endocrinology</jtitle><addtitle>Mol Cell Endocrinol</addtitle><date>1987-03</date><risdate>1987</risdate><volume>50</volume><issue>1</issue><spage>23</spage><epage>27</epage><pages>23-27</pages><issn>0303-7207</issn><eissn>1872-8057</eissn><coden>MCEND6</coden><abstract>The effect of adenohypophysial hormones on rat pineal melatonin content and release was examined in vitro. Medium concentration of radioimmunoassayable melatonin decreased after a 6 h exposure to 1–100 ng/ml FSH; pineal levels of melatonin were only decreased by 100 ng/ml FSH. LH (1–100 ng/ml) augmented significantly medium melatonin concentration, tissue levels being increased at 10 ng/ml LH. Parallel increases of explant and medium melatonin content were found after exposure to 1–100 ng/ml TSH. At the smallest concentration employed (1 ng/ml) prolactin increased melatonin content and release while at 100 ng/ml a significant depression of both parameters was found. Growth hormone (1–10 ng/ml) augmented melatonin levels in medium but failed to modify them at 100 ng/ml, although at this concentration tissue melatonin levels increased. ACTH did not modify pineal melatonin synthesis in vitro.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>3034698</pmid><doi>10.1016/0303-7207(87)90073-6</doi><tpages>5</tpages></addata></record> |
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| subjects | ACTH Adrenocorticotropic Hormone - pharmacology Animals Biological and medical sciences Follicle Stimulating Hormone - pharmacology FSH Fundamental and applied biological sciences. Psychology Growth hormone Growth Hormone - pharmacology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Luteinizing Hormone - pharmacology Male Melatonin - metabolism Organ Culture Techniques Pineal Gland - drug effects Pineal Gland - metabolism Pineal organ culture Pituitary Hormones, Anterior - pharmacology Prolactin Prolactin - pharmacology Rats Thyrotropin - pharmacology TSH Vertebrates: endocrinology |
| title | In vitro effects of adenohypophysial hormones on rat pineal melatonin content and release |
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