Implications of prolonged expression of Fos-related antigens
The AP-1 transcription factors are composed of the Fos and Fos-related antigens as well as Jun and related proteins. These factors have been extensively studied in many diverse paradigms using acute stimuli. Recent attention has focussed on long-term elevation of Fos-related antigens in the CNS, and...
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| Veröffentlicht in: | Trends in Pharmacological Sciences 1995-09, Vol.16 (9), p.317-321 |
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| creator | Pennypacker, Keith R. Hong, Jau-S. McMillian, Michael K. |
| description | The AP-1 transcription factors are composed of the Fos and Fos-related antigens as well as Jun and related proteins. These factors have been extensively studied in many diverse paradigms using acute stimuli. Recent attention has focussed on long-term elevation of Fos-related antigens in the CNS, and this is discussed by
Keith Pennypacker, Jau-S. Hong and Michael McMillian. Repeated or chronic treatment elevates Fos-related antigen levels for days in many different brain regions. Both direct and indirect stimulation are responsible for the protracted increase in Fos-related antigen-immunoreactive proteins, which may modulate late onset genes involved in neuroplasticity. Understanding the role of these factors in long-lasting or permanent disease states may provide insight into potential therapeutic strategies to treat chronic CNS disorders. |
| doi_str_mv | 10.1016/S0165-6147(00)89061-6 |
| format | Article |
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Keith Pennypacker, Jau-S. Hong and Michael McMillian. Repeated or chronic treatment elevates Fos-related antigen levels for days in many different brain regions. Both direct and indirect stimulation are responsible for the protracted increase in Fos-related antigen-immunoreactive proteins, which may modulate late onset genes involved in neuroplasticity. Understanding the role of these factors in long-lasting or permanent disease states may provide insight into potential therapeutic strategies to treat chronic CNS disorders.</description><identifier>ISSN: 0165-6147</identifier><identifier>EISSN: 1873-3735</identifier><identifier>DOI: 10.1016/S0165-6147(00)89061-6</identifier><identifier>PMID: 7482997</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Brain Injuries - metabolism ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - physiology ; Genes, fos ; Humans ; Proto-Oncogene Proteins c-fos - biosynthesis ; Proto-Oncogene Proteins c-fos - genetics ; Transcription Factor AP-1 - physiology</subject><ispartof>Trends in Pharmacological Sciences, 1995-09, Vol.16 (9), p.317-321</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-52dc7d924c7a8f23167a1777b7d03f53ef2dad6c5453b67737e3b7ff7cb877c93</citedby><cites>FETCH-LOGICAL-c482t-52dc7d924c7a8f23167a1777b7d03f53ef2dad6c5453b67737e3b7ff7cb877c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165614700890616$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,776,780,788,3537,27899,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7482997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pennypacker, Keith R.</creatorcontrib><creatorcontrib>Hong, Jau-S.</creatorcontrib><creatorcontrib>McMillian, Michael K.</creatorcontrib><title>Implications of prolonged expression of Fos-related antigens</title><title>Trends in Pharmacological Sciences</title><addtitle>Trends Pharmacol Sci</addtitle><description>The AP-1 transcription factors are composed of the Fos and Fos-related antigens as well as Jun and related proteins. These factors have been extensively studied in many diverse paradigms using acute stimuli. Recent attention has focussed on long-term elevation of Fos-related antigens in the CNS, and this is discussed by
Keith Pennypacker, Jau-S. Hong and Michael McMillian. Repeated or chronic treatment elevates Fos-related antigen levels for days in many different brain regions. Both direct and indirect stimulation are responsible for the protracted increase in Fos-related antigen-immunoreactive proteins, which may modulate late onset genes involved in neuroplasticity. Understanding the role of these factors in long-lasting or permanent disease states may provide insight into potential therapeutic strategies to treat chronic CNS disorders.</description><subject>Animals</subject><subject>Brain Injuries - metabolism</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - physiology</subject><subject>Genes, fos</subject><subject>Humans</subject><subject>Proto-Oncogene Proteins c-fos - biosynthesis</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Transcription Factor AP-1 - physiology</subject><issn>0165-6147</issn><issn>1873-3735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9LAzEQxYMotVY_QqEn0cNqstlkdkEQKVYLBQ_qOWST2RLZ7q7JVvTbm_6h115mYN6becOPkDGjd4wyef8ei0gky-CG0tu8oJIl8oQMWQ484cDFKRkeLOfkIoQvSinnKRuQAWR5WhQwJA_zVVc7o3vXNmHSVpPOt3XbLNFO8LfzGEIUNvNZGxKPte6jopveLbEJl-Ss0nXAq30fkc_Z88f0NVm8vcynT4vExJg-Eak1YIs0M6DzKuVMgmYAUIKlvBIcq9RqK43IBC8lAAfkJVQVmDIHMAUfkevd3fjc9xpDr1YuGKxr3WC7DgpAcM7S_KiRiSKnBaPRKHZG49sQPFaq826l_Z9iVG3wqi1etWGnKFVbvErGvfE-YF2u0B629jyj_rjTMeL4cehVMA4bg9Z5NL2yrTuS8A8tmYl7</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>Pennypacker, Keith R.</creator><creator>Hong, Jau-S.</creator><creator>McMillian, Michael K.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950901</creationdate><title>Implications of prolonged expression of Fos-related antigens</title><author>Pennypacker, Keith R. ; Hong, Jau-S. ; McMillian, Michael K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-52dc7d924c7a8f23167a1777b7d03f53ef2dad6c5453b67737e3b7ff7cb877c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Brain Injuries - metabolism</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation - physiology</topic><topic>Genes, fos</topic><topic>Humans</topic><topic>Proto-Oncogene Proteins c-fos - biosynthesis</topic><topic>Proto-Oncogene Proteins c-fos - genetics</topic><topic>Transcription Factor AP-1 - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pennypacker, Keith R.</creatorcontrib><creatorcontrib>Hong, Jau-S.</creatorcontrib><creatorcontrib>McMillian, Michael K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in Pharmacological Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pennypacker, Keith R.</au><au>Hong, Jau-S.</au><au>McMillian, Michael K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implications of prolonged expression of Fos-related antigens</atitle><jtitle>Trends in Pharmacological Sciences</jtitle><addtitle>Trends Pharmacol Sci</addtitle><date>1995-09-01</date><risdate>1995</risdate><volume>16</volume><issue>9</issue><spage>317</spage><epage>321</epage><pages>317-321</pages><issn>0165-6147</issn><eissn>1873-3735</eissn><abstract>The AP-1 transcription factors are composed of the Fos and Fos-related antigens as well as Jun and related proteins. These factors have been extensively studied in many diverse paradigms using acute stimuli. Recent attention has focussed on long-term elevation of Fos-related antigens in the CNS, and this is discussed by
Keith Pennypacker, Jau-S. Hong and Michael McMillian. Repeated or chronic treatment elevates Fos-related antigen levels for days in many different brain regions. Both direct and indirect stimulation are responsible for the protracted increase in Fos-related antigen-immunoreactive proteins, which may modulate late onset genes involved in neuroplasticity. Understanding the role of these factors in long-lasting or permanent disease states may provide insight into potential therapeutic strategies to treat chronic CNS disorders.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>7482997</pmid><doi>10.1016/S0165-6147(00)89061-6</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Brain Injuries - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Genes, fos Humans Proto-Oncogene Proteins c-fos - biosynthesis Proto-Oncogene Proteins c-fos - genetics Transcription Factor AP-1 - physiology |
| title | Implications of prolonged expression of Fos-related antigens |
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