Synthetic Studies on Condensed-Azole Derivatives. III. Synthesis and Anti-asthmatic Activities of C-Substituted Alkyl Side Chain Derivatives of ω-Sulfamoylalkylthioimidazo[1, 2-b]pyridazines and Related Compounds

A series of novel alkylthioimidazo[1, 2-b]pyridazines was synthesized and evaluated for ability to inhibit platelet activating factor (PAF)-induced bronchoconstriction in guinea pigs. Among them, 3-(imidazo[1, 2-b]pyridazin-6-yl)thio-2, 2-dimethylpropanesulfonamide (15) showed the most potent inhibi...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/09/15, Vol.43(9), pp.1516-1522
Hauptverfasser:	KUWAHARA, Masaaki, KAWANO, Yasuhiko, SHIMAZU, Hiroshi, YAMAMOTO, Hiroaki, ASHIDA, Yasuko, MIYAKE, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Asthmatic Agents - chemical synthesis Anti-Asthmatic Agents - pharmacology anti-asthmatic effect Biological and medical sciences Bronchodilator Agents - pharmacology Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Guinea Pigs imidazo[1, 2-b]pyridazin In Vitro Techniques Male Medical sciences Muscle Contraction - drug effects Muscle, Smooth - drug effects PAF-induced bronchoconstriction Pharmacology. Drug treatments Platelet Activating Factor - antagonists & inhibitors Respiratory system Structure-Activity Relationship Theophylline - pharmacology Thromboxane-A Synthase - antagonists & inhibitors Trachea - drug effects
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