Quantitation of triple-helix formation using a photo-cross-linkable aryl azide/biotin/oligonucleotide conjugate

DNA triple-helix formation has potential applications in gene mapping and as the basis of "antigene" pharmaceuticals; however, the methods for quantitation of triple-helix formation are limited, especially for purine(purine-pyrimidine)-based triplexes. We present a novel method for detecti...

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Veröffentlicht in:	Bioconjugate chemistry 1995-07, Vol.6 (4), p.502-506
Hauptverfasser:	Geselowitz, D A, Neumann, R D
Format:	Artikel
Sprache:	eng
Schlagworte:	Azides Base Sequence Biotin Chromosome Mapping Cross-Linking Reagents DNA - chemistry DNA - radiation effects Genes, myc Kinetics Light Molecular Sequence Data Nucleic Acid Conformation Oligodeoxyribonucleotides - chemistry Photochemistry Plasmids Succinimides
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