Determination of the Consensus Binding Site for MEF2 Expressed in Muscle and Brain Reveals Tissue-specific Sequence Constraints (∗)

The myocyte-specific enhancer factor-2 (MEF2) proteins are expressed in the three major types of muscle (skeletal, cardiac, and smooth) and function as transcriptional activators of muscle-specific and growth factor-regulated genes through binding to a canonical A/T-rich cis-element. Although MEF2 p...

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Veröffentlicht in:	The Journal of biological chemistry 1995-10, Vol.270 (40), p.23246-23249
Hauptverfasser:	Andrés, Vicente, Cervera, Margarita, Mahdavi, Vijak
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites Brain - growth & development Brain - metabolism Cells, Cultured Consensus Sequence DNA - genetics DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Developmental MEF2 Transcription Factors Mice Molecular Sequence Data Muscle Development Muscle, Skeletal - metabolism Muscles - metabolism Myocardium - metabolism Myogenic Regulatory Factors Organ Specificity Transcription Factors - genetics Transcription Factors - metabolism
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