Iodoacetylated ouabagenins: Their syntheses, spectroscopic characterizations, and stability studies

Ouabain shows high binding ability to myocardial Na +,K +-ATPase and, therefore, a suitably radiolabeled derivative of this compound may find use in myocardial imaging. In this pilot experiment we report the preparation of several chloroacetylated and iodoacetylated ouabagenins. These intermediates...

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Veröffentlicht in:	Steroids 1995-06, Vol.60 (6), p.477-483
Hauptverfasser:	Chatterjee, Mita, Chakravarty, Ajit K., Ganguly, Shantanu, Sarkar, Bharat R., Banerjee, Somenath
Format:	Artikel
Sprache:	eng
Schlagworte:	13C NMR 1H NMR Acetylation Alicyclic compounds, terpenoids, prostaglandins, steroids cardenolide aglycone Chemistry Chromatography, High Pressure Liquid Drug Stability Exact sciences and technology Iodine Radioisotopes Isotope Labeling Magnetic Resonance Spectroscopy Molecular Structure Myocardium - enzymology Na +,K +-ATPase inhibitor Organic chemistry ouabagenin Ouabain - analogs & derivatives Ouabain - chemistry Ouabain - metabolism Preparations and properties radioiodination Sodium-Potassium-Exchanging ATPase - metabolism Steroids
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