Map of spinal neurons activated by chemical stimulation in the nucleus raphe magnus of the unanesthetized rat
The expression of the proto-oncogene c- fos was used as a cellular marker of spinal cord neurons activated by microinjection of kainic acid into the medullary nucleus raphe magnus of awake and drug-free Sprague-Dawley rats. The c-FOS protein was detected by immunocytochemistry. We found increased im...
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| Veröffentlicht in: | Neuroscience 1995-07, Vol.67 (2), p.497-504 |
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| container_title | Neuroscience |
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| creator | Bett, K. Sandkühler, J. |
| description | The expression of the proto-oncogene c-
fos was used as a cellular marker of spinal cord neurons activated by microinjection of kainic acid into the medullary nucleus raphe magnus of awake and drug-free Sprague-Dawley rats. The c-FOS protein was detected by immunocytochemistry. We found increased immunoreactivity bilaterally in laminae I–VI of the dorsal horn. The strongest c-FOS expression was observed within the inner layer of lamina II near its border with lamina III. In the ventral horn no c-FOS immunoreactivity was observed. Thus, the present results provide evidence for a descending excitation of neurons predominantly in inner lamina II, possibly mediating nucleus raphe magnus-induced inhibition of neurons in other laminae. |
| doi_str_mv | 10.1016/0306-4522(95)00017-D |
| format | Article |
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fos was used as a cellular marker of spinal cord neurons activated by microinjection of kainic acid into the medullary nucleus raphe magnus of awake and drug-free Sprague-Dawley rats. The c-FOS protein was detected by immunocytochemistry. We found increased immunoreactivity bilaterally in laminae I–VI of the dorsal horn. The strongest c-FOS expression was observed within the inner layer of lamina II near its border with lamina III. In the ventral horn no c-FOS immunoreactivity was observed. Thus, the present results provide evidence for a descending excitation of neurons predominantly in inner lamina II, possibly mediating nucleus raphe magnus-induced inhibition of neurons in other laminae.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/0306-4522(95)00017-D</identifier><identifier>PMID: 7675181</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anatomy ; Animals ; Biological and medical sciences ; Central nervous system ; Fundamental and applied biological sciences. Psychology ; Genes, fos ; Kainic Acid - administration & dosage ; Kainic Acid - pharmacology ; Male ; Microinjections ; Neurons - drug effects ; Neurons - physiology ; Raphe Nuclei - drug effects ; Raphe Nuclei - physiology ; Rats ; Rats, Sprague-Dawley ; Spinal Cord - cytology ; Spinal Cord - drug effects ; Stimulation, Chemical ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 1995-07, Vol.67 (2), p.497-504</ispartof><rights>1995 IBRO</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4ab80061d73609aa139ea6720773d9e15fb04acd036cd0b08e60cb4428bcb9c13</citedby><cites>FETCH-LOGICAL-c417t-4ab80061d73609aa139ea6720773d9e15fb04acd036cd0b08e60cb4428bcb9c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/030645229500017D$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3522536$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7675181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bett, K.</creatorcontrib><creatorcontrib>Sandkühler, J.</creatorcontrib><title>Map of spinal neurons activated by chemical stimulation in the nucleus raphe magnus of the unanesthetized rat</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>The expression of the proto-oncogene c-
fos was used as a cellular marker of spinal cord neurons activated by microinjection of kainic acid into the medullary nucleus raphe magnus of awake and drug-free Sprague-Dawley rats. The c-FOS protein was detected by immunocytochemistry. We found increased immunoreactivity bilaterally in laminae I–VI of the dorsal horn. The strongest c-FOS expression was observed within the inner layer of lamina II near its border with lamina III. In the ventral horn no c-FOS immunoreactivity was observed. Thus, the present results provide evidence for a descending excitation of neurons predominantly in inner lamina II, possibly mediating nucleus raphe magnus-induced inhibition of neurons in other laminae.</description><subject>Anatomy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Genes, fos</topic><topic>Kainic Acid - administration & dosage</topic><topic>Kainic Acid - pharmacology</topic><topic>Male</topic><topic>Microinjections</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Raphe Nuclei - drug effects</topic><topic>Raphe Nuclei - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spinal Cord - cytology</topic><topic>Spinal Cord - drug effects</topic><topic>Stimulation, Chemical</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bett, K.</creatorcontrib><creatorcontrib>Sandkühler, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bett, K.</au><au>Sandkühler, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Map of spinal neurons activated by chemical stimulation in the nucleus raphe magnus of the unanesthetized rat</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1995-07-01</date><risdate>1995</risdate><volume>67</volume><issue>2</issue><spage>497</spage><epage>504</epage><pages>497-504</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>The expression of the proto-oncogene c-
fos was used as a cellular marker of spinal cord neurons activated by microinjection of kainic acid into the medullary nucleus raphe magnus of awake and drug-free Sprague-Dawley rats. The c-FOS protein was detected by immunocytochemistry. We found increased immunoreactivity bilaterally in laminae I–VI of the dorsal horn. The strongest c-FOS expression was observed within the inner layer of lamina II near its border with lamina III. In the ventral horn no c-FOS immunoreactivity was observed. Thus, the present results provide evidence for a descending excitation of neurons predominantly in inner lamina II, possibly mediating nucleus raphe magnus-induced inhibition of neurons in other laminae.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7675181</pmid><doi>10.1016/0306-4522(95)00017-D</doi><tpages>8</tpages></addata></record> |
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| ispartof | Neuroscience, 1995-07, Vol.67 (2), p.497-504 |
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| language | eng |
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| subjects | Anatomy Animals Biological and medical sciences Central nervous system Fundamental and applied biological sciences. Psychology Genes, fos Kainic Acid - administration & dosage Kainic Acid - pharmacology Male Microinjections Neurons - drug effects Neurons - physiology Raphe Nuclei - drug effects Raphe Nuclei - physiology Rats Rats, Sprague-Dawley Spinal Cord - cytology Spinal Cord - drug effects Stimulation, Chemical Vertebrates: nervous system and sense organs |
| title | Map of spinal neurons activated by chemical stimulation in the nucleus raphe magnus of the unanesthetized rat |
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