Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: Spontaneous recovery from the neutrophil abnormalities during early childhood
Childhood chronic neutropenia with decreased numbers of chemotactic factor receptors as well as defective chemotaxis was first demonstrated in an 8‐month‐old girl. Chemotactic factor receptors on neutrophils were assayed using tritiated N‐formyl‐methionyl‐leucyl‐phenylalanine (3H‐FMLP). The patient&...
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| Veröffentlicht in: | Am. J. Hematol.; (United States) 1987-05, Vol.25 (1), p.67-75 |
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| container_title | Am. J. Hematol.; (United States) |
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| creator | Yasui, Kozo Yamazaki, Munehiro Miyagawa, Yukiaki Komiyama, Atsushi Akabane, Taro |
| description | Childhood chronic neutropenia with decreased numbers of chemotactic factor receptors as well as defective chemotaxis was first demonstrated in an 8‐month‐old girl. Chemotactic factor receptors on neutrophils were assayed using tritiated N‐formyl‐methionyl‐leucyl‐phenylalanine (3H‐FMLP). The patient's neutrophils had decreased numbers of the receptors: numbers of the receptors were 20,000 (< 3 SD) as compared with those of control cells of 52,000 ± 6,000 (mean ± SD) (n = 10). The neutropenia disappeared spontaneously by 28 months of age parallel with the improvement of chemotaxis and increase in numbers of chemotactic factor receptors. These results demonstrate a transient decrease of neutrophil chemotactic factor receptors as one of the pathophysiological bases of a transient defect of neutrophil chemotaxis in this disorder. |
| doi_str_mv | 10.1002/ajh.2830250107 |
| format | Article |
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School of Medicine, Matsumoto, Japan</creatorcontrib><description>Childhood chronic neutropenia with decreased numbers of chemotactic factor receptors as well as defective chemotaxis was first demonstrated in an 8‐month‐old girl. Chemotactic factor receptors on neutrophils were assayed using tritiated N‐formyl‐methionyl‐leucyl‐phenylalanine (3H‐FMLP). The patient's neutrophils had decreased numbers of the receptors: numbers of the receptors were 20,000 (< 3 SD) as compared with those of control cells of 52,000 ± 6,000 (mean ± SD) (n = 10). The neutropenia disappeared spontaneously by 28 months of age parallel with the improvement of chemotaxis and increase in numbers of chemotactic factor receptors. These results demonstrate a transient decrease of neutrophil chemotactic factor receptors as one of the pathophysiological bases of a transient defect of neutrophil chemotaxis in this disorder.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.2830250107</identifier><identifier>PMID: 3578264</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>550901 - Pathology- Tracer Techniques ; AGE GROUPS ; Agranulocytosis - metabolism ; AMINO ACIDS ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOLOGICAL MATERIALS ; BIOLOGICAL RECOVERY ; BLOOD ; BLOOD CELLS ; BODY FLUIDS ; CARBOXYLIC ACIDS ; Cell Movement ; CHILDREN ; Chronic Disease ; DISEASES ; Female ; formyl‐methionyl‐leucyl‐phenylalanine (FMLP) ; Hematologic and hematopoietic diseases ; HEMIC DISEASES ; Humans ; immunodeficiency syndrome ; Infant ; ISOTOPE APPLICATIONS ; LABELLED COMPOUNDS ; LEUKOCYTES ; MATERIALS ; Medical sciences ; MEMBRANE PROTEINS ; N-Formylmethionine Leucyl-Phenylalanine - metabolism ; Neutropenia - metabolism ; neutrophil mobility ; NEUTROPHILS ; Neutrophils - cytology ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; Other diseases. Hematologic involvement in other diseases ; PATHOGENESIS ; PATIENTS ; phagocyte ; PHENYLALANINE ; PROTEINS ; RECEPTORS ; Receptors, Formyl Peptide ; Receptors, Immunologic - analysis ; RECOVERY ; TRACER TECHNIQUES ; Tritium ; TRITIUM COMPOUNDS</subject><ispartof>Am. J. 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School of Medicine, Matsumoto, Japan</creatorcontrib><title>Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: Spontaneous recovery from the neutrophil abnormalities during early childhood</title><title>Am. J. Hematol.; (United States)</title><addtitle>Am J Hematol</addtitle><description>Childhood chronic neutropenia with decreased numbers of chemotactic factor receptors as well as defective chemotaxis was first demonstrated in an 8‐month‐old girl. Chemotactic factor receptors on neutrophils were assayed using tritiated N‐formyl‐methionyl‐leucyl‐phenylalanine (3H‐FMLP). The patient's neutrophils had decreased numbers of the receptors: numbers of the receptors were 20,000 (< 3 SD) as compared with those of control cells of 52,000 ± 6,000 (mean ± SD) (n = 10). The neutropenia disappeared spontaneously by 28 months of age parallel with the improvement of chemotaxis and increase in numbers of chemotactic factor receptors. These results demonstrate a transient decrease of neutrophil chemotactic factor receptors as one of the pathophysiological bases of a transient defect of neutrophil chemotaxis in this disorder.</description><subject>550901 - Pathology- Tracer Techniques</subject><subject>AGE GROUPS</subject><subject>Agranulocytosis - metabolism</subject><subject>AMINO ACIDS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BIOLOGICAL RECOVERY</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>BODY FLUIDS</subject><subject>CARBOXYLIC ACIDS</subject><subject>Cell Movement</subject><subject>CHILDREN</subject><subject>Chronic Disease</subject><subject>DISEASES</subject><subject>Female</subject><subject>formyl‐methionyl‐leucyl‐phenylalanine (FMLP)</subject><subject>Hematologic and hematopoietic diseases</subject><subject>HEMIC DISEASES</subject><subject>Humans</subject><subject>immunodeficiency syndrome</subject><subject>Infant</subject><subject>ISOTOPE APPLICATIONS</subject><subject>LABELLED COMPOUNDS</subject><subject>LEUKOCYTES</subject><subject>MATERIALS</subject><subject>Medical sciences</subject><subject>MEMBRANE PROTEINS</subject><subject>N-Formylmethionine Leucyl-Phenylalanine - metabolism</subject><subject>Neutropenia - metabolism</subject><subject>neutrophil mobility</subject><subject>NEUTROPHILS</subject><subject>Neutrophils - cytology</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>PATHOGENESIS</subject><subject>PATIENTS</subject><subject>phagocyte</subject><subject>PHENYLALANINE</subject><subject>PROTEINS</subject><subject>RECEPTORS</subject><subject>Receptors, Formyl Peptide</subject><subject>Receptors, Immunologic - analysis</subject><subject>RECOVERY</subject><subject>TRACER TECHNIQUES</subject><subject>Tritium</subject><subject>TRITIUM COMPOUNDS</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EKkvhyg3JQojbLv6TOAm3qkALqsQBOFuOPSauEjvYTtv9WHxDvMq2cOM0I73fvJnRQ-glJTtKCHunrocdazlhNaGkeYQ2lHRi24qaPUYbwgUtPemeomcpXRNCadWSE3TC66Zlotqg3x9AR1AJDPbL1ENMOFisB5hCVjo7jW0pIeIIGubSJOx80WPwRfOw5Bhm8E7hW5cHbMBCmbqBe4s7l97jb3PwWXkISzr4hBuIe2xjmHAe4N5kcCNWvQ9xUqPLDhI2S3T-JwYVx33xc6MZQjDP0ROrxgQvjvUU_fj08fv55fbq68Xn87OrreadaLYV4byrFWe6srSqemVErxnrWde2qhK1pURQBZYZQ0XVdz1niplWCWsbykzPT9Hr1Tek7GTSLoMedPC-PChF1XWc8gK9XaE5hl8LpCwnlzSM4_qtbJqasYaQAu5WUMeQUgQr5-gmFfeSEnkIUpYg5d8gy8Cro_PST2Ae8GNyRX9z1FXSarRRee3SA9aWtaI97O1W7NaNsP_PUnn25fKfE_4AUFi7jQ</recordid><startdate>198705</startdate><enddate>198705</enddate><creator>Yasui, Kozo</creator><creator>Yamazaki, Munehiro</creator><creator>Miyagawa, Yukiaki</creator><creator>Komiyama, Atsushi</creator><creator>Akabane, Taro</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198705</creationdate><title>Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: Spontaneous recovery from the neutrophil abnormalities during early childhood</title><author>Yasui, Kozo ; Yamazaki, Munehiro ; Miyagawa, Yukiaki ; Komiyama, Atsushi ; Akabane, Taro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3967-403395a32c4f144bad6bc22b2988a465f1061aef2dd164b9b32a2d8a6ff712db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>550901 - Pathology- Tracer Techniques</topic><topic>AGE GROUPS</topic><topic>Agranulocytosis - metabolism</topic><topic>AMINO ACIDS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BIOLOGICAL RECOVERY</topic><topic>BLOOD</topic><topic>BLOOD CELLS</topic><topic>BODY FLUIDS</topic><topic>CARBOXYLIC ACIDS</topic><topic>Cell Movement</topic><topic>CHILDREN</topic><topic>Chronic Disease</topic><topic>DISEASES</topic><topic>Female</topic><topic>formyl‐methionyl‐leucyl‐phenylalanine (FMLP)</topic><topic>Hematologic and hematopoietic diseases</topic><topic>HEMIC DISEASES</topic><topic>Humans</topic><topic>immunodeficiency syndrome</topic><topic>Infant</topic><topic>ISOTOPE APPLICATIONS</topic><topic>LABELLED COMPOUNDS</topic><topic>LEUKOCYTES</topic><topic>MATERIALS</topic><topic>Medical sciences</topic><topic>MEMBRANE PROTEINS</topic><topic>N-Formylmethionine Leucyl-Phenylalanine - metabolism</topic><topic>Neutropenia - metabolism</topic><topic>neutrophil mobility</topic><topic>NEUTROPHILS</topic><topic>Neutrophils - cytology</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>Other diseases. Hematologic involvement in other diseases</topic><topic>PATHOGENESIS</topic><topic>PATIENTS</topic><topic>phagocyte</topic><topic>PHENYLALANINE</topic><topic>PROTEINS</topic><topic>RECEPTORS</topic><topic>Receptors, Formyl Peptide</topic><topic>Receptors, Immunologic - analysis</topic><topic>RECOVERY</topic><topic>TRACER TECHNIQUES</topic><topic>Tritium</topic><topic>TRITIUM COMPOUNDS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yasui, Kozo</creatorcontrib><creatorcontrib>Yamazaki, Munehiro</creatorcontrib><creatorcontrib>Miyagawa, Yukiaki</creatorcontrib><creatorcontrib>Komiyama, Atsushi</creatorcontrib><creatorcontrib>Akabane, Taro</creatorcontrib><creatorcontrib>Shinshu Univ. School of Medicine, Matsumoto, Japan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Am. J. Hematol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasui, Kozo</au><au>Yamazaki, Munehiro</au><au>Miyagawa, Yukiaki</au><au>Komiyama, Atsushi</au><au>Akabane, Taro</au><aucorp>Shinshu Univ. School of Medicine, Matsumoto, Japan</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: Spontaneous recovery from the neutrophil abnormalities during early childhood</atitle><jtitle>Am. J. Hematol.; (United States)</jtitle><addtitle>Am J Hematol</addtitle><date>1987-05</date><risdate>1987</risdate><volume>25</volume><issue>1</issue><spage>67</spage><epage>75</epage><pages>67-75</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>Childhood chronic neutropenia with decreased numbers of chemotactic factor receptors as well as defective chemotaxis was first demonstrated in an 8‐month‐old girl. Chemotactic factor receptors on neutrophils were assayed using tritiated N‐formyl‐methionyl‐leucyl‐phenylalanine (3H‐FMLP). The patient's neutrophils had decreased numbers of the receptors: numbers of the receptors were 20,000 (< 3 SD) as compared with those of control cells of 52,000 ± 6,000 (mean ± SD) (n = 10). The neutropenia disappeared spontaneously by 28 months of age parallel with the improvement of chemotaxis and increase in numbers of chemotactic factor receptors. These results demonstrate a transient decrease of neutrophil chemotactic factor receptors as one of the pathophysiological bases of a transient defect of neutrophil chemotaxis in this disorder.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3578264</pmid><doi>10.1002/ajh.2830250107</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0361-8609 |
| ispartof | Am. J. Hematol.; (United States), 1987-05, Vol.25 (1), p.67-75 |
| issn | 0361-8609 1096-8652 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 550901 - Pathology- Tracer Techniques AGE GROUPS Agranulocytosis - metabolism AMINO ACIDS BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL MATERIALS BIOLOGICAL RECOVERY BLOOD BLOOD CELLS BODY FLUIDS CARBOXYLIC ACIDS Cell Movement CHILDREN Chronic Disease DISEASES Female formyl‐methionyl‐leucyl‐phenylalanine (FMLP) Hematologic and hematopoietic diseases HEMIC DISEASES Humans immunodeficiency syndrome Infant ISOTOPE APPLICATIONS LABELLED COMPOUNDS LEUKOCYTES MATERIALS Medical sciences MEMBRANE PROTEINS N-Formylmethionine Leucyl-Phenylalanine - metabolism Neutropenia - metabolism neutrophil mobility NEUTROPHILS Neutrophils - cytology ORGANIC ACIDS ORGANIC COMPOUNDS Other diseases. Hematologic involvement in other diseases PATHOGENESIS PATIENTS phagocyte PHENYLALANINE PROTEINS RECEPTORS Receptors, Formyl Peptide Receptors, Immunologic - analysis RECOVERY TRACER TECHNIQUES Tritium TRITIUM COMPOUNDS |
| title | Decreased numbers of chemotactic factor receptors in chronic neutropenia with defective chemotaxis: Spontaneous recovery from the neutrophil abnormalities during early childhood |
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