The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons
The nicotinic antagonists d-tubocurarine and trimethaphan camsylate competitively inhibit GABA-induced currents. Hexamethonium, mecamylamine and dihydro-β-erythroidine, other nicotinic antagonists, do not affect GABA-elicited currents. The trimethaphan effect is completely reversed by a putative con...
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| Veröffentlicht in: | Neuroscience 1995-07, Vol.67 (2), p.293-300 |
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| creator | Wotring, V.E. Yoon, K.-W. |
| description | The nicotinic antagonists d-tubocurarine and trimethaphan camsylate competitively inhibit GABA-induced currents. Hexamethonium, mecamylamine and dihydro-β-erythroidine, other nicotinic antagonists, do not affect GABA-elicited currents. The trimethaphan effect is completely reversed by a putative convulsant receptor antagonist, α-isopropyl-α-methylγ-butyrolactone, which implies that the trimethaphan binding site may be closely associated with the convulsant site. However, nicotine was ineffective in competing for either the d-tubocurarine or trimethaphan effect at the GABA
A receptor.
From these observations, we proposed that the nicotinic and GABA
A receptor ionophore complexes share similar configurational patterns that accomodate some of the same molecules. Possible mechanisms for the trimethaphan and d-tubocurarine blockades are discussed. |
| doi_str_mv | 10.1016/0306-4522(95)00011-7 |
| format | Article |
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From these observations, we proposed that the nicotinic and GABA
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A receptor.
From these observations, we proposed that the nicotinic and GABA
A receptor ionophore complexes share similar configurational patterns that accomodate some of the same molecules. Possible mechanisms for the trimethaphan and d-tubocurarine blockades are discussed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Central nervous system</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA Antagonists - pharmacology</subject><subject>GABA-A Receptor Antagonists</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Membrane Potentials - drug effects</subject><subject>Molecular Conformation</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Nicotinic Agonists - pharmacology</subject><subject>Nicotinic Antagonists - pharmacology</subject><subject>Patch-Clamp Techniques</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYNY6tr6DRTyIMU-jObvZPIibIutQsGX9jlkMjfdyGwyJjPCfvtm3WUf9eXmwvndQzgHofeUfKaEtl8IJ20jJGOftLwmhFDaqFdoRTvFGyWFeI1WJ-QNelvKrwoRKfg5OletklSRFXp-3AAOcRP6MKe8w-A9uLng5HEMLs2hTmzjbJ9TDGUvROyWnCHWHcbgwgwD7nf4fn2zrkY42xlvwjQlZ7eTHXGEJadYLtGZt2OBd8f3Aj3dfXu8_d48_Lz_cbt-aJygam5aoh0lAFpwxZQaBk6Z1sxb3UtpofNt61vmuReCC-k7YL1XkgDrQPMq8Qt0dfCdcvq9QJnNNhQH42gjpKUYpWoapNP_BWnbUS0pqaA4gC6nUjJ4M-WwtXlnKDH7Isw-ZbNP2Whp_hZhVD37cPRf-i0Mp6Nj8lX_eNRtcXb02UYXygnjknFGecW-HjCoof0JkE1xAaKDIeRalBlS-Pc_XgDzNqPH</recordid><startdate>19950701</startdate><enddate>19950701</enddate><creator>Wotring, V.E.</creator><creator>Yoon, K.-W.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950701</creationdate><title>The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons</title><author>Wotring, V.E. ; Yoon, K.-W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-609c10ee9437277dd312992fa9b55ae8f66f62f3f44345f8e2bf750e28e936f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Central nervous system</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA Antagonists - pharmacology</topic><topic>GABA-A Receptor Antagonists</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Membrane Potentials - drug effects</topic><topic>Molecular Conformation</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Nicotinic Agonists - pharmacology</topic><topic>Nicotinic Antagonists - pharmacology</topic><topic>Patch-Clamp Techniques</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wotring, V.E.</creatorcontrib><creatorcontrib>Yoon, K.-W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wotring, V.E.</au><au>Yoon, K.-W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1995-07-01</date><risdate>1995</risdate><volume>67</volume><issue>2</issue><spage>293</spage><epage>300</epage><pages>293-300</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>The nicotinic antagonists d-tubocurarine and trimethaphan camsylate competitively inhibit GABA-induced currents. Hexamethonium, mecamylamine and dihydro-β-erythroidine, other nicotinic antagonists, do not affect GABA-elicited currents. The trimethaphan effect is completely reversed by a putative convulsant receptor antagonist, α-isopropyl-α-methylγ-butyrolactone, which implies that the trimethaphan binding site may be closely associated with the convulsant site. However, nicotine was ineffective in competing for either the d-tubocurarine or trimethaphan effect at the GABA
A receptor.
From these observations, we proposed that the nicotinic and GABA
A receptor ionophore complexes share similar configurational patterns that accomodate some of the same molecules. Possible mechanisms for the trimethaphan and d-tubocurarine blockades are discussed.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7675170</pmid><doi>10.1016/0306-4522(95)00011-7</doi><tpages>8</tpages></addata></record> |
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| ispartof | Neuroscience, 1995-07, Vol.67 (2), p.293-300 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Cells, Cultured Central nervous system Electrophysiology Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology GABA-A Receptor Antagonists gamma-Aminobutyric Acid - pharmacology Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Membrane Potentials - drug effects Molecular Conformation Neurons - drug effects Neurons - metabolism Nicotinic Agonists - pharmacology Nicotinic Antagonists - pharmacology Patch-Clamp Techniques Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs |
| title | The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons |
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