Effects of MCI-225 on memory and glucose utilization in basal forebrain-lesioned rats

The effects of MCI-225 on amnesia, the cerebral glucose metabolism, and choline acetyltransferase (ChAT) activity in basal forebrain (BF)-lesioned rats were studied in comparison with those of tacrine. Bilateral BF lesions with ibotenic acid impaired the performance in passive avoidance (PA) tasks....

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1995-08, Vol.51 (4), p.935-939
Hauptverfasser:	Eguchi, Junichi, Iwai, Kunihisa, Yuasa, Takayuki, Egawa, Mitsuo, Komatsu, Teiko, Saito, Ken-Ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avoidance Learning - drug effects BF lesion Biological and medical sciences Brain Chemistry - drug effects ChAT Choline O-Acetyltransferase - metabolism Glucose - metabolism Hippocampus - drug effects Hippocampus - enzymology Hippocampus - metabolism LCGU Male MCI-225 Medical sciences Memory - drug effects Neuropharmacology Parietal Lobe - drug effects Parietal Lobe - enzymology Parietal Lobe - metabolism Pharmacology. Drug treatments Piperazines - pharmacology Prosencephalon - physiology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Psychotropic Drugs - pharmacology Pyrimidines - pharmacology Rats Rats, Wistar Tacrine Tacrine - pharmacology
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