Defibrotide, an antithrombotic substance which prevents myocardial contracture in ischemic rabbit heart

Defibrotide, a polydeoxyribonucleotide obtained from mammalian lungs, reduced in a dose-dependent fashion the ischemic contracture due to low perfusion (0.2 ml/min) of isovolumic left heart of rabbit and abolished the irregular rhytym of the heart, thereby restoring the cardiomechanical activity upo...

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Veröffentlicht in:	European journal of pharmacology 1987-03, Vol.135 (3), p.375-382
Hauptverfasser:	Berti, Ferruccio, Rossoni, Giuseppe, Omini, Claudio, Folco, Giancarlo, Daffonchio, Luisa, Viganó, Teresa, Tondo, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Coronary Disease - physiopathology Defibrotide Dinoprostone Epoprostenol - pharmacology Fibrinolytic Agents - pharmacology In Vitro Techniques Indomethacin Indomethacin - pharmacology Male Medical sciences Myocardial Contraction - drug effects Myocardial ischemia Pharmacology. Drug treatments Platelet Aggregation - drug effects Polydeoxyribonucleotides - pharmacology Prostaglandins Prostaglandins E - pharmacology Rabbits
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