Increased cerebrospinal fluid concentrations of C-but not N-terminal cholecystokinin fragments in multiple sclerosis
The sulfated N-terminus and the car☐yamidated C-terminus of cholecystokinin octapeptide (CCK-8) were radioimmunoassayed in cerebrospinal fluid from 19 patients with multiple sclerosis (MS) and 17 control subjects. While the N-terminal immunoreactivity was normal in all phases of MS, the concentratio...
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| Veröffentlicht in: | Brain research 1987-04, Vol.409 (2), p.364-366 |
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| container_end_page | 366 |
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| container_title | Brain research |
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| creator | Bryld, Elisabeth Zeeberg, Ib Gjerris, Annette Werdelin, Lene Rehfeld, Jens F. |
| description | The sulfated N-terminus and the car☐yamidated C-terminus of cholecystokinin octapeptide (CCK-8) were radioimmunoassayed in cerebrospinal fluid from 19 patients with multiple sclerosis (MS) and 17 control subjects. While the N-terminal immunoreactivity was normal in all phases of MS, the concentration of C-terminal CCK immunoreactivity was significantly increased from3.7
±0.3 to7.9
±1.0pmol/l (mean
±S.E.M.) in both progressive and stable phases. The results indicate that C-terminal forms of CCK are released at an increased rate or that increased amounts of CCK-8 are released together with enhanced aminopeptidase activity in MS. |
| doi_str_mv | 10.1016/0006-8993(87)90723-2 |
| format | Article |
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±0.3 to7.9
±1.0pmol/l (mean
±S.E.M.) in both progressive and stable phases. The results indicate that C-terminal forms of CCK are released at an increased rate or that increased amounts of CCK-8 are released together with enhanced aminopeptidase activity in MS.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(87)90723-2</identifier><identifier>PMID: 3580883</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Biological and medical sciences ; Cerebrospinal fluid ; Cholecystokinin ; Humans ; Medical sciences ; Multiple sclerosis ; Multiple Sclerosis - cerebrospinal fluid ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Neuropeptide ; Peptide Fragments - cerebrospinal fluid ; Radioimmunoassay ; Radioimmunoassay - methods ; Sincalide - cerebrospinal fluid</subject><ispartof>Brain research, 1987-04, Vol.409 (2), p.364-366</ispartof><rights>1987 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-d689caf6142eadc48694e46e4cd9933efcd2551ca4de6663a78c1a9734d63ae93</citedby><cites>FETCH-LOGICAL-c301t-d689caf6142eadc48694e46e4cd9933efcd2551ca4de6663a78c1a9734d63ae93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(87)90723-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8243405$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3580883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bryld, Elisabeth</creatorcontrib><creatorcontrib>Zeeberg, Ib</creatorcontrib><creatorcontrib>Gjerris, Annette</creatorcontrib><creatorcontrib>Werdelin, Lene</creatorcontrib><creatorcontrib>Rehfeld, Jens F.</creatorcontrib><title>Increased cerebrospinal fluid concentrations of C-but not N-terminal cholecystokinin fragments in multiple sclerosis</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The sulfated N-terminus and the car☐yamidated C-terminus of cholecystokinin octapeptide (CCK-8) were radioimmunoassayed in cerebrospinal fluid from 19 patients with multiple sclerosis (MS) and 17 control subjects. While the N-terminal immunoreactivity was normal in all phases of MS, the concentration of C-terminal CCK immunoreactivity was significantly increased from3.7
±0.3 to7.9
±1.0pmol/l (mean
±S.E.M.) in both progressive and stable phases. The results indicate that C-terminal forms of CCK are released at an increased rate or that increased amounts of CCK-8 are released together with enhanced aminopeptidase activity in MS.</description><subject>Biological and medical sciences</subject><subject>Cerebrospinal fluid</subject><subject>Cholecystokinin</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Neuropeptide</subject><subject>Peptide Fragments - cerebrospinal fluid</subject><subject>Radioimmunoassay</subject><subject>Radioimmunoassay - methods</subject><subject>Sincalide - cerebrospinal fluid</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2OFCEUhYnRjD2jb6AJC2PGRSkUFEVtJjEdfyaZ6EbXhL7cUpSCFiiTeXvp6U4vXZHDPedw-Qh5wdlbzrh6xxhTnZ4mca3HNxMbe9H1j8iG67HvVC_ZY7I5W56Sy1J-NSnExC7IhRg001psSL2NkNEWdBQw4y6nsvfRBjqH1be7FAFjzbb6FAtNM912u7XSmCr90lXMy4MZfqaAcF9q-u2jj3TO9sfScoU2sayh-n1AWiBg6_flGXky21Dw-em8It8_fvi2_dzdff10u31_14FgvHZO6QnsrLjs0TqQWk0SpUIJrn1J4AyuHwYOVjpUSgk7auB2GoV0TeAkrsjrY-8-pz8rlmoWXwBDsBHTWsw4DlyLaWhGeTRC269knM0--8Xme8OZOcA2B5LmQNLo0TzANn2LvTz1r7sF3Tl0otvmr05zW8CGRiWCL2eb7qWQ7PD6zdGGjcVfj9kU8NjAO58RqnHJ_3-Pfy1mnbw</recordid><startdate>19870421</startdate><enddate>19870421</enddate><creator>Bryld, Elisabeth</creator><creator>Zeeberg, Ib</creator><creator>Gjerris, Annette</creator><creator>Werdelin, Lene</creator><creator>Rehfeld, Jens F.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870421</creationdate><title>Increased cerebrospinal fluid concentrations of C-but not N-terminal cholecystokinin fragments in multiple sclerosis</title><author>Bryld, Elisabeth ; Zeeberg, Ib ; Gjerris, Annette ; Werdelin, Lene ; Rehfeld, Jens F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-d689caf6142eadc48694e46e4cd9933efcd2551ca4de6663a78c1a9734d63ae93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Biological and medical sciences</topic><topic>Cerebrospinal fluid</topic><topic>Cholecystokinin</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - cerebrospinal fluid</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Neuropeptide</topic><topic>Peptide Fragments - cerebrospinal fluid</topic><topic>Radioimmunoassay</topic><topic>Radioimmunoassay - methods</topic><topic>Sincalide - cerebrospinal fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bryld, Elisabeth</creatorcontrib><creatorcontrib>Zeeberg, Ib</creatorcontrib><creatorcontrib>Gjerris, Annette</creatorcontrib><creatorcontrib>Werdelin, Lene</creatorcontrib><creatorcontrib>Rehfeld, Jens F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bryld, Elisabeth</au><au>Zeeberg, Ib</au><au>Gjerris, Annette</au><au>Werdelin, Lene</au><au>Rehfeld, Jens F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased cerebrospinal fluid concentrations of C-but not N-terminal cholecystokinin fragments in multiple sclerosis</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1987-04-21</date><risdate>1987</risdate><volume>409</volume><issue>2</issue><spage>364</spage><epage>366</epage><pages>364-366</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The sulfated N-terminus and the car☐yamidated C-terminus of cholecystokinin octapeptide (CCK-8) were radioimmunoassayed in cerebrospinal fluid from 19 patients with multiple sclerosis (MS) and 17 control subjects. While the N-terminal immunoreactivity was normal in all phases of MS, the concentration of C-terminal CCK immunoreactivity was significantly increased from3.7
±0.3 to7.9
±1.0pmol/l (mean
±S.E.M.) in both progressive and stable phases. The results indicate that C-terminal forms of CCK are released at an increased rate or that increased amounts of CCK-8 are released together with enhanced aminopeptidase activity in MS.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3580883</pmid><doi>10.1016/0006-8993(87)90723-2</doi><tpages>3</tpages></addata></record> |
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| ispartof | Brain research, 1987-04, Vol.409 (2), p.364-366 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Cerebrospinal fluid Cholecystokinin Humans Medical sciences Multiple sclerosis Multiple Sclerosis - cerebrospinal fluid Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuropeptide Peptide Fragments - cerebrospinal fluid Radioimmunoassay Radioimmunoassay - methods Sincalide - cerebrospinal fluid |
| title | Increased cerebrospinal fluid concentrations of C-but not N-terminal cholecystokinin fragments in multiple sclerosis |
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