Biological effects of a murine retrovirus carrying an activated N- ras gene of human origin

We have introduced a genomic DNA clone of a mutated human N- ras gene from a T-cell leukemia cell line into a retroviral vector equipped with a neo resistance gene and with SV40 and pBR322 origins of replication. The helper free N- ras virus, which was recovered after transfection of the constructio...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1987-05, Vol.158 (1), p.69-78
Hauptverfasser:	Souyri, Michèle, Koehne, Charles F., O'Donnell, Paul V., Aldrich, Thomas H., Furth, Mark E., Fleissner, Erwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Cloning, Molecular DNA, Recombinant Fibrosarcoma - microbiology Fundamental and applied biological sciences. Psychology Genes, Viral Genetic Vectors Genetics Humans Leukemia, Experimental - microbiology Mice Mice, Inbred AKR Mice, Inbred BALB C Microbiology Moloney murine leukemia virus - genetics Oncogenes Transfection Virology
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