Nitric oxide synthase activity is inducible in rat, but not rabbit alveolar macrophages, with a concomitant reduction in arginase activity

Alveolar macrophages were obtained by broncho-alveolar lavage of isolated rat and rabbit lungs and cultured (2.5 x 10(6) cells/dish) for 18 h in the absence or presence of bacterial lipopolysaccharides (LPS) alone or in combination with cytokines. Thereafter, accumulation of 3H-citrulline (NO syntha...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1995-06, Vol.351 (6), p.651-659
Hauptverfasser:	Hey, C, Wessler, I, Racké, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - biosynthesis Amino Acid Oxidoreductases - drug effects Animals Arginase - metabolism Arginine - analogs & derivatives Arginine - pharmacology Citrulline - metabolism Cytokines - pharmacology Dexamethasone - pharmacology Enzyme Induction Female In Vitro Techniques Lipopolysaccharides - pharmacology Macrophages, Alveolar - drug effects Macrophages, Alveolar - enzymology Male Nitric Oxide - antagonists & inhibitors Nitric Oxide Synthase Nitrites - metabolism omega-N-Methylarginine Ornithine - metabolism Rabbits Rats Rats, Sprague-Dawley
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