Bone marrow transplantation for acute nonlymphoblastic leukemia during first complete remission: a analysis of prognostic factors
Sixty-nine patients with acute nonlymphocytic leukemia in first remission received total-body irradiation and chemotherapy followed by allogeneic bone marrow transplantation from histocompatible sibling donors. Patient age was between 1 and 41 years: 20 patients 1-19 years (group 1); 27 patients 20-...
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| Veröffentlicht in: | Transplantation 1987-05, Vol.43 (5), p.650-653 |
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| creator | FORMAN, S. J KRANCE, R. A SNIECINSKI, I. J METTER, G. E HILL, L. R NATHWANI, M. B BLUME, K. G O'DONNELL, M. R NADEMANEE, A. P SNYDER, D. S FAHEY, J. L SCHMIDT, G. M ZAIA, J. A LIPSETT, J. A FINDLEY, D. O |
| description | Sixty-nine patients with acute nonlymphocytic leukemia in first remission received total-body irradiation and chemotherapy followed by allogeneic bone marrow transplantation from histocompatible sibling donors. Patient age was between 1 and 41 years: 20 patients 1-19 years (group 1); 27 patients 20-29 years (group 2); and 22 patients 30-41 years (group 3). Two pretransplant radiochemotherapy regimens were employed: The first 45 patients received total-body irradiation (in a single dose) with cytosine arabinoside and cyclophosphamide; the next 24 patients received total-body irradiation (in a fractionated schedule) with cyclophosphamide alone. For all patients, actuarial disease-free survival is 51% (37 of 69 patients are alive and in continuous remission between 5 months and 9.3 years, median 3.7 years). For group 1 actuarial survival is 56%, group 2 48%, and group 3 48%. When analyzed for pretransplant factors that might predict disease-free survival after bone marrow transplantation neither patient age, white cell count at the time of diagnosis, FAB leukemic subtype, length of time before achieving remission, nor length of time between remission and bone marrow transplantation were established as prognostic. |
| doi_str_mv | 10.1097/00007890-198705000-00009 |
| format | Article |
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J ; KRANCE, R. A ; SNIECINSKI, I. J ; METTER, G. E ; HILL, L. R ; NATHWANI, M. B ; BLUME, K. G ; O'DONNELL, M. R ; NADEMANEE, A. P ; SNYDER, D. S ; FAHEY, J. L ; SCHMIDT, G. M ; ZAIA, J. A ; LIPSETT, J. A ; FINDLEY, D. O</creator><creatorcontrib>FORMAN, S. J ; KRANCE, R. A ; SNIECINSKI, I. J ; METTER, G. E ; HILL, L. R ; NATHWANI, M. B ; BLUME, K. G ; O'DONNELL, M. R ; NADEMANEE, A. P ; SNYDER, D. S ; FAHEY, J. L ; SCHMIDT, G. M ; ZAIA, J. A ; LIPSETT, J. A ; FINDLEY, D. O</creatorcontrib><description>Sixty-nine patients with acute nonlymphocytic leukemia in first remission received total-body irradiation and chemotherapy followed by allogeneic bone marrow transplantation from histocompatible sibling donors. Patient age was between 1 and 41 years: 20 patients 1-19 years (group 1); 27 patients 20-29 years (group 2); and 22 patients 30-41 years (group 3). Two pretransplant radiochemotherapy regimens were employed: The first 45 patients received total-body irradiation (in a single dose) with cytosine arabinoside and cyclophosphamide; the next 24 patients received total-body irradiation (in a fractionated schedule) with cyclophosphamide alone. For all patients, actuarial disease-free survival is 51% (37 of 69 patients are alive and in continuous remission between 5 months and 9.3 years, median 3.7 years). For group 1 actuarial survival is 56%, group 2 48%, and group 3 48%. When analyzed for pretransplant factors that might predict disease-free survival after bone marrow transplantation neither patient age, white cell count at the time of diagnosis, FAB leukemic subtype, length of time before achieving remission, nor length of time between remission and bone marrow transplantation were established as prognostic.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-198705000-00009</identifier><identifier>PMID: 3554657</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Acute Disease ; Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Bone Marrow Transplantation ; Child ; Child, Preschool ; Graft vs Host Disease - prevention & control ; Hematologic and hematopoietic diseases ; Humans ; Infant ; Leukemia - drug therapy ; Leukemia - mortality ; Leukemia - therapy ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocyte Count ; Medical sciences</subject><ispartof>Transplantation, 1987-05, Vol.43 (5), p.650-653</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7388252$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3554657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FORMAN, S. J</creatorcontrib><creatorcontrib>KRANCE, R. A</creatorcontrib><creatorcontrib>SNIECINSKI, I. J</creatorcontrib><creatorcontrib>METTER, G. E</creatorcontrib><creatorcontrib>HILL, L. R</creatorcontrib><creatorcontrib>NATHWANI, M. B</creatorcontrib><creatorcontrib>BLUME, K. G</creatorcontrib><creatorcontrib>O'DONNELL, M. R</creatorcontrib><creatorcontrib>NADEMANEE, A. P</creatorcontrib><creatorcontrib>SNYDER, D. S</creatorcontrib><creatorcontrib>FAHEY, J. L</creatorcontrib><creatorcontrib>SCHMIDT, G. M</creatorcontrib><creatorcontrib>ZAIA, J. A</creatorcontrib><creatorcontrib>LIPSETT, J. A</creatorcontrib><creatorcontrib>FINDLEY, D. O</creatorcontrib><title>Bone marrow transplantation for acute nonlymphoblastic leukemia during first complete remission: a analysis of prognostic factors</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Sixty-nine patients with acute nonlymphocytic leukemia in first remission received total-body irradiation and chemotherapy followed by allogeneic bone marrow transplantation from histocompatible sibling donors. Patient age was between 1 and 41 years: 20 patients 1-19 years (group 1); 27 patients 20-29 years (group 2); and 22 patients 30-41 years (group 3). Two pretransplant radiochemotherapy regimens were employed: The first 45 patients received total-body irradiation (in a single dose) with cytosine arabinoside and cyclophosphamide; the next 24 patients received total-body irradiation (in a fractionated schedule) with cyclophosphamide alone. For all patients, actuarial disease-free survival is 51% (37 of 69 patients are alive and in continuous remission between 5 months and 9.3 years, median 3.7 years). For group 1 actuarial survival is 56%, group 2 48%, and group 3 48%. When analyzed for pretransplant factors that might predict disease-free survival after bone marrow transplantation neither patient age, white cell count at the time of diagnosis, FAB leukemic subtype, length of time before achieving remission, nor length of time between remission and bone marrow transplantation were established as prognostic.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Graft vs Host Disease - prevention & control</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukemia - drug therapy</subject><subject>Leukemia - mortality</subject><subject>Leukemia - therapy</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocyte Count</subject><subject>Medical sciences</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP7DAMhSN0EQyPn4CUxRW7QtI0dcoOEC8JiQ2sR24mgUKalCQVmiX_nMAdsb3eWPb5dGQfQihnJ5x1cMpKgepYxTsFTJap-l51W2TBpWiqlin2hywYa3jFhYBdspfSayGkANghO0LKppWwIJ8XwRs6Yozhg-aIPk0OfcY8BE9tiBT1nA31wbv1OL2E3mHKg6bOzG9mHJCu5jj4Z2qHmDLVYZycKXwsWkrF44wiRY9unYZEg6VTDM8-_FhY1DnEdEC2LbpkDjd9nzxdXz1e3lb3Dzd3l-f31VS3ba6QrxrATlnW8x4bEDXCSunym1S9bdu-txZRQKdQWK4NMm5Fb03NEbHrjNgnx_98ywnvs0l5WU7UxpV3TZjTEkByqCX7L8gbAM5-wKMNOPejWS2nOJQg18tNuEX_u9ExaXS2pKuH9IuBUKqWtfgCOSGOYQ</recordid><startdate>19870501</startdate><enddate>19870501</enddate><creator>FORMAN, S. J</creator><creator>KRANCE, R. A</creator><creator>SNIECINSKI, I. J</creator><creator>METTER, G. E</creator><creator>HILL, L. R</creator><creator>NATHWANI, M. 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O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone marrow transplantation for acute nonlymphoblastic leukemia during first complete remission: a analysis of prognostic factors</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>43</volume><issue>5</issue><spage>650</spage><epage>653</epage><pages>650-653</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Sixty-nine patients with acute nonlymphocytic leukemia in first remission received total-body irradiation and chemotherapy followed by allogeneic bone marrow transplantation from histocompatible sibling donors. Patient age was between 1 and 41 years: 20 patients 1-19 years (group 1); 27 patients 20-29 years (group 2); and 22 patients 30-41 years (group 3). Two pretransplant radiochemotherapy regimens were employed: The first 45 patients received total-body irradiation (in a single dose) with cytosine arabinoside and cyclophosphamide; the next 24 patients received total-body irradiation (in a fractionated schedule) with cyclophosphamide alone. For all patients, actuarial disease-free survival is 51% (37 of 69 patients are alive and in continuous remission between 5 months and 9.3 years, median 3.7 years). For group 1 actuarial survival is 56%, group 2 48%, and group 3 48%. When analyzed for pretransplant factors that might predict disease-free survival after bone marrow transplantation neither patient age, white cell count at the time of diagnosis, FAB leukemic subtype, length of time before achieving remission, nor length of time between remission and bone marrow transplantation were established as prognostic.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>3554657</pmid><doi>10.1097/00007890-198705000-00009</doi><tpages>4</tpages></addata></record> |
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| ispartof | Transplantation, 1987-05, Vol.43 (5), p.650-653 |
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| subjects | Acute Disease Adolescent Adult Age Factors Biological and medical sciences Bone Marrow Transplantation Child Child, Preschool Graft vs Host Disease - prevention & control Hematologic and hematopoietic diseases Humans Infant Leukemia - drug therapy Leukemia - mortality Leukemia - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Count Medical sciences |
| title | Bone marrow transplantation for acute nonlymphoblastic leukemia during first complete remission: a analysis of prognostic factors |
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