The distribution of vasoactive intestinal peptide2 receptor messenger RNA in the rat brain and pituitary gland as assessed by in situ hybridization
The distribution of rat vasoactive intestinal peptide2 (VIP2) receptor messenger RNA in the brain and the pituitary gland was examined by in situ hybridization and by ribonuclease protection assay. labelled cells were found chiefly in the suprachiasmatic nucleus, the central nucleus of the amygdala...
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| Veröffentlicht in: | Neuroscience 1995-07, Vol.67 (2), p.409-418 |
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| creator | SHEWARD, W. J LUTZ, E. M HARMAR, A. J |
| description | The distribution of rat vasoactive intestinal peptide2 (VIP2) receptor messenger RNA in the brain and the pituitary gland was examined by in situ hybridization and by ribonuclease protection assay. labelled cells were found chiefly in the suprachiasmatic nucleus, the central nucleus of the amygdala and the thalamus (the lateral geniculate nucleus, and the paraventricular, mediodorsal and ventral nuclei of the thalamus). The distribution of the VIP2 receptor overlaps only in part with that of the VIP1 receptor, for example in the hippocampus, where VIP2 receptor messenger RNA was found in the pyramidal cells of the CA1-CA3 subfields and in the granule cells of the dentate gyrus. Small numbers of neurons containing high concentrations of VIP2 receptor messenger RNA were present in the brainstem in the principal sensory trigeminal nucleus and in the substantia gelatinosa of the spinal cord, suggesting a role for the VIP2 receptor in the processing of sensory information. The presence of the VIP2 receptor in the suprachiasmatic nucleus suggests that it is this receptor subtype which is involved in the control of circadian rhythms. |
| doi_str_mv | 10.1016/0306-4522(95)00048-n |
| format | Article |
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Small numbers of neurons containing high concentrations of VIP2 receptor messenger RNA were present in the brainstem in the principal sensory trigeminal nucleus and in the substantia gelatinosa of the spinal cord, suggesting a role for the VIP2 receptor in the processing of sensory information. The presence of the VIP2 receptor in the suprachiasmatic nucleus suggests that it is this receptor subtype which is involved in the control of circadian rhythms.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/0306-4522(95)00048-n</identifier><identifier>PMID: 7675176</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Brain - cytology ; Brain - metabolism ; Cell receptors ; Cell structures and functions ; Fundamental and applied biological sciences. 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J</creatorcontrib><creatorcontrib>LUTZ, E. M</creatorcontrib><creatorcontrib>HARMAR, A. J</creatorcontrib><title>The distribution of vasoactive intestinal peptide2 receptor messenger RNA in the rat brain and pituitary gland as assessed by in situ hybridization</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>The distribution of rat vasoactive intestinal peptide2 (VIP2) receptor messenger RNA in the brain and the pituitary gland was examined by in situ hybridization and by ribonuclease protection assay. labelled cells were found chiefly in the suprachiasmatic nucleus, the central nucleus of the amygdala and the thalamus (the lateral geniculate nucleus, and the paraventricular, mediodorsal and ventral nuclei of the thalamus). The distribution of the VIP2 receptor overlaps only in part with that of the VIP1 receptor, for example in the hippocampus, where VIP2 receptor messenger RNA was found in the pyramidal cells of the CA1-CA3 subfields and in the granule cells of the dentate gyrus. Small numbers of neurons containing high concentrations of VIP2 receptor messenger RNA were present in the brainstem in the principal sensory trigeminal nucleus and in the substantia gelatinosa of the spinal cord, suggesting a role for the VIP2 receptor in the processing of sensory information. The presence of the VIP2 receptor in the suprachiasmatic nucleus suggests that it is this receptor subtype which is involved in the control of circadian rhythms.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - cytology</subject><subject>Brain - metabolism</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Neurons - metabolism</subject><subject>Neuropeptide receptors</subject><subject>Pituitary Gland - anatomy & histology</subject><subject>Pituitary Gland - cytology</subject><subject>Pituitary Gland - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Vasoactive Intestinal Peptide - biosynthesis</subject><subject>Ribonucleases - metabolism</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Spinal Cord - metabolism</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kd9qFTEQxkNR2mPtGyjkQoperOZ_di9LaVUoFUq9Dtlk0kb27G6TbOH4Gn1hs_ZwIDAZ5vcNM98g9IGSr5RQ9Y1wohohGfvcyS-EENE24xHa0FbzRksh3qDNATlB73L-UyEiBT9Gx1ppSbXaoJf7R8A-5pJiv5Q4jXgK-NnmyboSnwHHsUAucbQDnmEu0QPDCVz9TglvIWcYHyDhu9uLiuJSmyVbcJ9szezo8RzLEotNO_wwrLnN9eVV53G_WzW5Evhx16fo41-7jvAevQ12yHC2j6fo9_XV_eWP5ubX95-XFzeN44qXBqhwATqmrAqEU6pJ3bTtuzaIjgviGSPUQeeJ0r3gPITQcU-F4s4y6YDzU3T-2ndO09NS1zTbmB0MdVCYlmx09Ui0WlZQvIIuTTknCGZOcVuXMpSY9RZmNdqsRptOmv-3MLdV9nHff-m34A-ivfm1_mlft9nZISQ7upgPGJeMM8b4P9oHk8k</recordid><startdate>199507</startdate><enddate>199507</enddate><creator>SHEWARD, W. 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J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-e14cfe926a6f0311704528b98f49340d2201ce9d067b433fff93d1463ca25ce33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - cytology</topic><topic>Brain - metabolism</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Neurons - metabolism</topic><topic>Neuropeptide receptors</topic><topic>Pituitary Gland - anatomy & histology</topic><topic>Pituitary Gland - cytology</topic><topic>Pituitary Gland - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Vasoactive Intestinal Peptide - biosynthesis</topic><topic>Ribonucleases - metabolism</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Spinal Cord - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHEWARD, W. J</creatorcontrib><creatorcontrib>LUTZ, E. M</creatorcontrib><creatorcontrib>HARMAR, A. 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The distribution of the VIP2 receptor overlaps only in part with that of the VIP1 receptor, for example in the hippocampus, where VIP2 receptor messenger RNA was found in the pyramidal cells of the CA1-CA3 subfields and in the granule cells of the dentate gyrus. Small numbers of neurons containing high concentrations of VIP2 receptor messenger RNA were present in the brainstem in the principal sensory trigeminal nucleus and in the substantia gelatinosa of the spinal cord, suggesting a role for the VIP2 receptor in the processing of sensory information. The presence of the VIP2 receptor in the suprachiasmatic nucleus suggests that it is this receptor subtype which is involved in the control of circadian rhythms.</abstract><cop>Oxford</cop><pub>Elsevier</pub><pmid>7675176</pmid><doi>10.1016/0306-4522(95)00048-n</doi><tpages>10</tpages></addata></record> |
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| ispartof | Neuroscience, 1995-07, Vol.67 (2), p.409-418 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Brain - cytology Brain - metabolism Cell receptors Cell structures and functions Fundamental and applied biological sciences. Psychology In Situ Hybridization Male Molecular and cellular biology Neurons - metabolism Neuropeptide receptors Pituitary Gland - anatomy & histology Pituitary Gland - cytology Pituitary Gland - metabolism Rats Rats, Wistar Receptors, Vasoactive Intestinal Peptide - biosynthesis Ribonucleases - metabolism RNA, Messenger - biosynthesis Spinal Cord - metabolism |
| title | The distribution of vasoactive intestinal peptide2 receptor messenger RNA in the rat brain and pituitary gland as assessed by in situ hybridization |
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