Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein

Mannan-binding protein (MBP) is a serum lectin participating in the innate immune defense by opsonizing various microorganisms for phagocytosis. Opsonization defect due to MBP deficiency and low levels of the protein can partially be explained by the dominant effect of three different mutations in t...

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Veröffentlicht in:	The Journal of immunology (1950) 1995-09, Vol.155 (6), p.3013-3020
Hauptverfasser:	Madsen, HO, Garred, P, Thiel, S, Kurtzhals, JA, Lamm, LU, Ryder, LP, Svejgaard, A
Format:	Artikel
Sprache:	eng
Schlagworte:	African Continental Ancestry Group - genetics Base Sequence Carrier Proteins - blood Carrier Proteins - genetics Collectins European Continental Ancestry Group - genetics Gene Frequency Haplotypes Humans Inuits Molecular Sequence Data Polymorphism, Genetic Promoter Regions, Genetic - genetics
Online-Zugang:	Volltext
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